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Histone Acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.
Cat No. product name
T7856 Naphthol AS-E nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
T3217 PF-CBP1 hydrochloride PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
T2452 C646 C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T11807 L002 L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
T9102 WM-3835 WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
T11366 Garcinol Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
T9373 DCH36_06 DCH36_06  as a bona fide is a potent p300/CBP inhibitor
T8658 NEO2734 NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T6811 CPI-637 CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T6389 Anacardic Acid Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial acti...
T6133 Remodelin hydrobromide Remodelin HBr salt is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
T3969 I-CBP112 I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T15216 EML 425 EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T5468 YF-2 YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T8344 CPTH2 CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
T6584 MG 149 MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T1516 Curcumin Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin bl...
T6668 SGC-CBP30 SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T0065 Acetaminophen Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, bloo...
T11563 Histone Acetyltransferase Inhibitor II Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity in...
T6908 NSC 228155 NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T9167 PF-9363 PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
T12098 MOZ-IN-2 MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
T12345 CBP/p300-IN-3 P300/CBP-IN-3 is an inhibitor of p300/CBP histone acetyltransferase.
T3499 Remodelin Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
T4679 WM-1119 WM-1119 is a highly potent, selective KAT6A/B inhibitor
T4362 WM-8014 MOZ-IN-3 is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
T14073 A-485 A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
Naphthol AS-E
T7856
nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
Procyanidin B3
TN1150
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
PF-CBP1 hydrochloride
T3217
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
C646
T2452
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
L002
T11807
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
WM-3835
T9102
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
Garcinol
T11366
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and ant...
DCH36_06
T9373
DCH36_06  as a bona fide is a potent p300/CBP inhibitor
NEO2734
T8658
NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
CPI-637
T6811
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
Anacardic Acid
T6389
Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial acti...
Remodelin hydrobromide
T6133
Remodelin HBr salt is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
I-CBP112
T3969
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
EML 425
T15216
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
YF-2
T5468
CPTH2
T8344
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
MG 149
T6584
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
Curcumin
T1516
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin bl...
SGC-CBP30
T6668
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
Acetaminophen
T0065
Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, bloo...
Histone Acetyltransferase Inhibitor II
T11563
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity i...
NSC 228155
T6908
NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
PF-9363
T9167
PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
MOZ-IN-2
T12098
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
CBP/p300-IN-3
T12345
P300/CBP-IN-3 is an inhibitor of p300/CBP histone acetyltransferase.
Remodelin
T3499
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
WM-1119
T4679
WM-1119 is a highly potent, selective KAT6A/B inhibitor
WM-8014
T4362
MOZ-IN-3 is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
A-485
T14073
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).