Histone Acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

Cat. No.	Product name	CAS No.	Purity
T23095	NU 9056	1450644-28-6	95.36%
T23095	NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein a...
T78815	MOZ-IN-3		98%
T78815	MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cel...
T79086	MC4171		98%
T79086	MC4171 (compound 34), a selective KAT8 inhibitor (IC50=8.1 µM), demonstrates moderate antiproliferative activity at micromolar concentrations in various cancer c...
T79131	KAT modulator-1	1314006-43-3	98%
T79131	KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].
T0065	Acetaminophen	103-90-2	99.99%
T0065	Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak ...
T4362	WM-8014	2055397-18-5	99.95%
T4362	WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
T6811	CPI-637	1884712-47-3	99.91%
T6811	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T12098	MOZ-IN-2	2055397-88-9	99.89%
T12098	MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
T60558	NSC 694623	907957-34-0	99.87%
T60558	NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with IC50 of 15.9 μM against recombinant HAT p300/CBP associated factor (PCAF). NSC 694623 shows...
T7856	Naphthol AS-E	92-78-4	99.85%
T7856	Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T6908	NSC 228155	113104-25-9	99.84%
T6908	NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T3499	Remodelin	949912-58-7	99.78%
T3499	Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
T15014	CTPB	586976-24-1	99.77%
T15014	CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments.
TN1150	Procyanidin B3	23567-23-9	99.71%
TN1150	Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
T8344	CPTH2	357649-93-5	99.5%
T8344	CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
T2452	C646	328968-36-1	99.21%
T2452	C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T5468	YF-2	1311423-89-8	99.19%
T5468	YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T71832	CTX-0124143	423731-64-0	99.16%
T71832	CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.
T25215	CCT077791	748777-47-1	99.15%
T25215	CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.
T12345	CBP/p300-IN-3	2299226-01-8	99.14%
T12345	CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.