Mitophagy

Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. In addition to the selective removal of damaged mitochondria, mitophagy is also required to adjust mitochondrial numbers to changing cellular metabolic needs, for steady-state mitochondrial turnover, and during certain cellular developmental stages, such as during cellular differentiation of red blood cells.

Cat. No.	Product name	CAS No.	Purity
T2870	Matrine	519-02-8	100%
T2870	Matrine, an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T1554	Iohexol	66108-95-0	80.18%
T1554	Iohexol is an X-ray contrast medium containing iohexol in various concentrations, from 140 to 350 milligrams of iodine per milliliter.
T1516	Curcumin	458-37-7	97.51%
T1516	Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin bl...
T1131	Ivermectin	70288-86-7	97.74%
T1131	Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T6714	URB-597	546141-08-6	97.84%
T6714	URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T2174	Quercetin	117-39-5	98.05%
T2174	Quercetin, a natural flavonoid present in vegetables, fruit, and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor.
T0876	Clioquinol	130-26-7	98.09%
T0876	Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activitie...
T0374	Sunitinib Malate	341031-54-7	98.23%
T0374	Sunitinib is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
T1907	Mdivi-1	338967-87-6	98.64%
T1907	Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) (IC50: 1-10 μ...
T3427	Polydatin	27208-80-6	98.83%
T3427	Polydatin, the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and ele...
T1602	Valproic acid sodium salt	1069-66-5	99%
T1602	Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
T7064	Valproic Acid	99-66-1	99%
T7064	Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
T0595	Naringin	10236-47-2	99.04%
T0595	Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibitio...
T1020	Doxorubicin hydrochloride	25316-40-9	99.06%
T1020	Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
T0005	Aspirin	50-78-2	99.09%
T0005	Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicyl...
T8929	BC1618	2222094-18-8	99.09%
T8929	BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
T6062	Brefeldin A	20350-15-6	99.2%
T6062	Brefeldin A , a Penicillium brefeldianum metabolite, which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. It is also an ATPase inhibito...
T0972	Isoniazid	54-85-3	99.21%
T0972	Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
T0947	Dexamethasone acetate	1177-87-3	99.22%
T0947	Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bind...
T2414	Torkinib	1092351-67-1	99.23%
T2414	Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).