NOD

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress. They are types of pattern recognition receptors (PRRs), and play key roles in the regulation of innate immune response. NLRs can cooperate with toll-like receptors (TLRs) and regulate inflammatory and apoptotic response. They are found in lymphocytes, macrophages, dendritic cells and also in non-immune cells, for example in epithelium. NLRs are highly conserved through evolution. Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein)

Cat No.	product name
T0109	Molsidomine	Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO...
T0122	Bengenin	Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T13378	Z-Asp-CH2-DCB	Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.
T15052	Dapansutrile	Dapansutrile is an orally active inhibitor of NLRP3 inflammasome. It has anti-inflammatory and analgesic activity.
T2845	Imperatorin	Imperatorin is a modulator of p38,ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T3230	NLRP3 Inflammasome Inhibitor I	It is a NLRP3 Inflammasome Inhibitor I.
T3587	NOD-IN-1	NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
T3701	MCC950	CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and c...
T4164	CY-09	CY-09 is an NLRP3 inhibitor.
T4217	INF39	INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
T5838	L-Canavanine sulfate	L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
T6591	ML130	Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T6887	MCC950 sodium	MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
T6S1367	Procyanidin B2	Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 in...
T7597	6-Biopterin	6-Biopterin is a natural product,is a NO synthase cofactor.
TN1273	4',7-Dihydroxyflavone	4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.