NOD

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress. They are types of pattern recognition receptors (PRRs), and play key roles in the regulation of innate immune response. NLRs can cooperate with toll-like receptors (TLRs) and regulate inflammatory and apoptotic response. They are found in lymphocytes, macrophages, dendritic cells and also in non-immune cells, for example in epithelium. NLRs are highly conserved through evolution. Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein)

Cat No.	product name
T0109	Molsidomine	Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO...
T0122	Bengenin	Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T13378	Z-Asp-CH2-DCB	Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.
T15052	Dapansutrile	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
T2845	Imperatorin	Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T3092	Nigericin sodium salt	Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi fun...
T3230	NLRP3 Inflammasome Inhibitor I	It is a NLRP3 Inflammasome Inhibitor I.
T3587	NOD-IN-1	NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
T3701	MCC950	CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and c...
T4164	CY09	CY-09 is an NLRP3 inhibitor.
T4217	INF39	INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
T5838	L-Canavanine sulfate	L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
T6591	ML130	Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T6887	MCC950 sodium	MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
T6S1367	Procyanidin B2	Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 in...
T7597	6-Biopterin	6-Biopterin is a natural product,is a NO synthase cofactor.
T7682	Asymmetric dimethylarginine	Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)
TN1273	4',7-Dihydroxyflavone	4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
TQ0165	Arglabin	Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
TQ0165	Arglabin	Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

Cat No.

product name

T0109

Molsidomine

Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO...

T0122

Bengenin

Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.

T13378

Z-Asp-CH2-DCB

Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.

T15052

Dapansutrile

Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.

T2845

Imperatorin

Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.

T3092

Nigericin sodium salt

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi fun...

T3230

NLRP3 Inflammasome Inhibitor I

It is a NLRP3 Inflammasome Inhibitor I.

T3587

NOD-IN-1

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.

T3701

MCC950

CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and c...

T4164

CY09

CY-09 is an NLRP3 inhibitor.

T4217

INF39

INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.

T5838

L-Canavanine sulfate

L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

T6591

ML130

Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.

T6887

MCC950 sodium

MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.

T6S1367

Procyanidin B2

Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 in...

T7597

6-Biopterin

6-Biopterin is a natural product,is a NO synthase cofactor.

T7682

Asymmetric dimethylarginine

Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)

TN1273

4',7-Dihydroxyflavone

4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.

TQ0165

Arglabin

Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

TQ0165

Arglabin

Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.