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Immunology / Inflammation NOD

NOD

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress. They are types of pattern recognition receptors (PRRs), and play key roles in the regulation of innate immune response. NLRs can cooperate with toll-like receptors (TLRs) and regulate inflammatory and apoptotic response. They are found in lymphocytes, macrophages, dendritic cells and also in non-immune cells, for example in epithelium. NLRs are highly conserved through evolution. Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein)
Cat No. product name
T0109 Molsidomine Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO...
T0122 Bengenin Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T2845 Imperatorin Imperatorin is a modulator of p38,ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T3230 NLRP3 Inflammasome Inhibitor I It is a NLRP3 Inflammasome Inhibitor I.
T3587 NOD-IN-1 NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
T3701 MCC950 CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and c...
T4164 CY-09 CY-09 is an NLRP3 inhibitor.
T4217 INF39 INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
T6591 ML130 Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T6887 MCC950 sodium MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
T5838 L-Canavanine sulfate L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
T6S1367 Procyanidin B2 Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 in...
T7597 6-Biopterin 6-Biopterin is a natural product,is a NO synthase cofactor.
TN1273 4',7-Dihydroxyflavone 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
T15052 Dapansutrile Dapansutrile is an orally active inhibitor of NLRP3 inflammasome. It has anti-inflammatory and analgesic activity.
T13378 Z-Asp-CH2-DCB Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.
Molsidomine
T0109CAS 25717-80-0
Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO...
Bengenin
T0122CAS 477-90-7
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Imperatorin
T2845CAS 482-44-0
Imperatorin is a modulator of p38,ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
NLRP3 Inflammasome Inhibitor I
T3230CAS 16673-34-0
It is a NLRP3 Inflammasome Inhibitor I.
NOD-IN-1
T3587CAS 132819-92-2
NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
MCC950
T3701CAS 210826-40-7
CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and c...
CY-09
T4164CAS 1073612-91-5
CY-09 is an NLRP3 inhibitor.
INF39
T4217CAS 866028-26-4
INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
ML130
T6591CAS 799264-47-4
Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
MCC950 sodium
T6887CAS 256373-96-3
MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
L-Canavanine sulfate
T5838CAS 2219-31-0
L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
Procyanidin B2
T6S1367CAS 29106-49-8
Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 in...
6-Biopterin
T7597CAS 22150-76-1
6-Biopterin is a natural product,is a NO synthase cofactor.
4',7-Dihydroxyflavone
TN1273CAS 2196-14-7
4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
Dapansutrile
T15052CAS 54863-37-5
Dapansutrile is an orally active inhibitor of NLRP3 inflammasome. It has anti-inflammatory and analgesic activity.
Z-Asp-CH2-DCB
T13378CAS 153088-73-4
Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.