Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.

Cat No.	product name
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 是胰蛋白酶样蛋白酶的抑制剂。 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 对 IFN-γ 活性具有抑制作用。
T1674	Nateglinide	Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diab...
T2316	Omarigliptin	Omarigliptin has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.
T2470	MDL-28170	Calpain Inhibitor III is a Cysteine protease.
T3695	Pepstatin	Pepstatin is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin.
T7133	Anagliptin	Anagliptin is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.
T7369L	Gemigliptin Tartrate(911637-19-9 free base)	Gemigliptin tartrate is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombina...
T2583	Cilastatin	Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which res...
T3028	Tripterin	Celastrol is an effective proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome(IC50=2.5 μM) with antioxidant and anti-inflammator...
T2122	Ixazomib	MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC5...
T0191	Linagliptin	Linagliptin is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
T7917	4'-Hydroxychalcone	4'-Hydroxychalcone is a chalcone metabolite with hepatoprotective activity
T7369	Gemigliptin	Gemigliptin is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
T6237	Trelagliptin	Trelagliptin is a highly specific and long-acting DPP-4 inhibitor.
T0178	Saxagliptin hydrate	Saxagliptin is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).
T6192	Alogliptin	Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
T15079	DBPR108	DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.
T8397	Ixazomib citrate	Ixazomib citrate is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential ...
T6999	Teneligliptin hydrobromide	Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-...
T16684	Puromycin aminonucleoside	Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T2399	Bortezomib	Bortezomib (PS-341) is a potent 20S proteasome inhibitor (Ki: 0.6 nM, in a cell-free assay).
T8350	TPCK	TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
T21510	PSI	PSI is a proteasome inhibitor.
T21854	Proteasome inhibitor IX	AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). AM 114 shows potent anticancer activity. AM 114 exhibits HCT116 p53+/+ c...
T6583	MG-101	MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T2401	Alogliptin Benzoate	Alogliptin Benzoate(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may...
T6041	Oprozomib	Oprozomib (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5（IC50=36 nM）/LMP7（IC50=82 nM）, is orally bioavailable. Oprozomib also has potential ant...
T6830	Epoxomicin	Epoxomicin is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH ca...
T2745	18α-Glycyrrhetinic acid	Enoxolone (INN, BAN; also known as glycyrrhetinic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrh...
T2370	AC-55541	AOB2796 is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assay...
T1502	Vildagliptin	Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiet...
T12710	Retagliptin Phosphate	Retagliptin Phosphate is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.
T2493	PD 151746	PD 151746 is a selective, cell-permeable calpain inhibitor (Ki: 0.26/5.33 μM, μ-Calpain/m-calpain).
T4042	Talabostat mesylate	Talabostat mesylate is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation ...
T0372	Gabexate mesylate	Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a ...
T6027	Delanzomib	CEP-18770 is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and peptidylgluta...
T2154	MG-132	MG-132 is a potent cell-permeable 26S proteasome inhibitor (IC50: 100 nM). It also inhibits calpain (IC50: 1.2 μM).
T6203	Saxagliptin	Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
T1795	Carfilzomib	Carfilzomib is an irreversible proteasome inhibitor and antineoplastic agent that is used in treatment of refractory multiple myeloma.
T0242	Sitagliptin	Sitagliptin, a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either alone or...
T1176	Racecadotril	Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
T8550	NDMC101	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 a...
T6432	Calpeptin	Calpeptin is a potent, cell-permeable calpain inhibitor.
T6029	ONX-0914	ONX-0914 is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.
T7016	VR23	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for ca...
TP1961L	PR 39 (porcine) acetate	PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor. PR 39 (porcine) acetate reversibly binds to the α7 subunit of the pr...
T2296	Trelagliptin succinate	Trelagliptin(SYR-472) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D).
T3359	Aprotinin	Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, ...
T16838	Saikogenin A	Saikogenin A is a dipeptidyl peptidase-4 inhibitor.
T3786	Tomatine	An antiproliferatve agent of breast adenocarcinoma cells.