Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.

Cat. No.	Product name	CAS No.	Purity
T15702	Lactacystin	133343-34-7	98%
T15702	Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacyst...
T16568	PR-924	1416709-79-9	98%
T16568	PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple...
T0242L	Sitagliptin phosphate monohydrate	654671-77-9	98%
T0242L	Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
T12561	Proteasome-IN-1	374080-21-4	98%
T12561	Proteasome-IN-1 is an inhibitor of proteasome.
T15678	KZR-504	1629052-78-3	98%
T15678	KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).
T11924	M3258	2285330-15-4	98%
T11924	LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor of imm...
T21617	MG-115	133407-86-0	98%
T21617	MG-115 is a potent and reversible proteasome inhibitor, with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the c...
T7369L	Gemigliptin Tartrate(911637-19-9 free base)	1374639-74-3	98%
T7369L	Gemigliptin tartrate is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombina...
T10238	Aclacinomycin A hydrochloride	75443-99-1	98%
T10238	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (c...
T36902	RA375		98%
T36902	RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater a...
T39214L	LXE408 fumarate		98%
T39214L	LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani pro...
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride	4272-74-6	98%
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride is an inhibitor of trypsin-like protease. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride exhib...
T1502	Vildagliptin	274901-16-5
T1502	Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiet...
T3359	Aprotinin	9087-70-1
T3359	Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, ...
T7814	Alloxan monohydrate	2244-11-3
T7814	Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.
T2470	MDL-28170	88191-84-8
T2470	Calpain Inhibitor III is a Cysteine protease.
T7369	Gemigliptin	911637-19-9
T7369	Gemigliptin is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
T8397	Ixazomib citrate	1239908-20-3	100%
T8397	Ixazomib citrate is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential ...
T6999	Teneligliptin hydrobromide	906093-29-6	100%
T6999	Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-...
T7133	Anagliptin	739366-20-2	100%
T7133	Anagliptin is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.