7β,27 dihydroxy cholesterol

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .

Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP(1-7)-GRF(8-27) is a selective antagonist [1] for the vasoactive intestinal peptide 1 (VIP 1) receptor.

Compound 15, known as 5,4'-Dihydroxy-7-methoxy-6-methylflavane, is a natural product present in Chinese Dragon’s Blood [1].

2',4'-Dihydroxy-7-methoxy-8-prenylflavan is a natural product for research related to life sciences. The catalog number is TN2720 and the CAS number is 331954-16-6.

3,4'-Dihydroxy-3,5',7-trimethoxyflavan is a natural product for research related to life sciences. The catalog number is TN2878 and the CAS number is 97914-19-7.

(3R,5R)-3,5-dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptane may have anti-adipogenic activity.

16,17-Dihydroxy-7-kauranone is a useful organic compound for research related to life sciences. The catalog number is T125840 and the CAS number is 145701-00-4.

2',4'-Dihydroxy-3,7':4,8'-diepoxylign-7-ene is a natural product for research related to life sciences. The catalog number is TN2716 and the CAS number is 666250-52-8.

The compound 6-[(1R,2S)-2,3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxy has been isolated from the stem of Angelica dahurica, marking its first discovery from a plant source [1].

[K15,R16,L27]VIP(1-7)/GRF(8-27), a selective agonist for the VIP 1 receptor, demonstrates binding IC 50 values of 2 nM for the human VIP 1, 1 nM for the rat VIP 1, and 30,000 nM for the rat VIP 2 receptors, respectively [1]. VIP stands for VASOACTIVE Intestinal Polypeptide.

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

2,9-Dihydroxy-7-methoxy-4-methylnaphtho[1,2-b]fura is a useful organic compound for research related to life sciences. The catalog number is T125732 and the CAS number is 1558053-97-6.

1,5-Epoxy-3-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane is a natural product for research related to life sciences. The catalog number is TN5758 and the CAS number is 182369-54-6.

(2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR,9bR)-2,9b-Dihydroxy-4a,6a-dimethylhexadecahydro-1H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-7(7aH)-one is a useful organic compound for research related to life sciences. The catalog number is T67508 and the CAS number is 82543-16-6.

27-Alkyne Cholesterol, an alkyne derivative of cholesterol, facilitates the investigation of cholesterol metabolism and localization through click chemistry with reporter azides in both fixed and living cells. It serves as a substrate for enzymes across diverse species such as bacteria, yeast, rat, and human.

7-Keto-25-hydroxy Cholesterol, an oxysterol and proposed metabolite of 7-keto cholesterol and 7-dehydro cholesterol, binds to and activates Smoothened (Smo) at the conserved extracellular cysteine-rich domain (CRD) in a reporter assay. Additionally, it enhances the number of EGF high affinity binding sites in normal rat kidney (NRK) cells.

2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-1H-purine-6,8-dione is a useful organic compound for research related to life sciences and the catalog number is TNU1307.

3,11-Dihydroxy-7-drimen-6-one is a useful organic compound for research related to life sciences and the catalog number is T130890.

2',4',5',7'-Tetrabromo-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylic acid is a useful organic compound for research related to life sciences and the catalog number is T66348.

6,4'-Dihydroxy-7-methoxyflavan is a natural product for research related to life sciences. The catalog number is TN5482 and the CAS number is 202463-50-1.

2',7-Dihydroxy-5,8-dimethoxyflavanone is a natural product of Scutellaria, Lamiaceae. The catalog number is TN2745 and the CAS number is 1351338-14-1. 2',7-Dihydroxy-5,8-dimethoxyflavanone can be used as a reference standard.

(R)-Methyl 4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a useful organic compound for research related to life sciences. The catalog number is T66136 and the CAS number is 10538-65-5.

4α,8β-Dihydroxy-3α-(2-hydroxy-3-acetoxy-2-methylbutyryloxy)eudesm-7(11)-en-12,8α-olide is a natural product for research related to life sciences. The catalog number is TN5399 and the CAS number is 1442989-33-4.

[K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate) is an acetate salt form of the peptide [K15,R16,L27]VIP(1-7)/GRF(8-27). This compound acts as a selective agonist for the VIP 1 receptor, displaying IC50 values of 2 nM for human VIP 1, 1 nM for rat VIP 1, and 30,000 nM for rat VIP 2 receptors [1]. The peptide's acronym, VIP, stands for Vasoactive Intestinal Polypeptide.

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.