carboxamide

(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid is a potential SSTR4 agonist.

5-(2-furyl)-N-propylisoxazole-3-carboxamide is a compound used as a molecular structural unit and is thought to be a modulator of NMDA receptors, and has been shown to be protective against glutamate-induced excitotoxicity and oxidative stress in neuronal cells. It has also been found to have anti-inflammatory activity, making it a potential therapeutic agent for diseases such as Alzheimer's disease and Parkinson's disease.

3- Phenyl- N- [1- (phenylmethyl) - 4- piperidinyl] -tricyclo[3.3.1.13, 7] decane- 1- carboxamide with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells. In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 μM.

N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nM.

1H-Pyrazole-5-carboxamide, 4-(5-chloro-2-furanyl)-1,3-bis(2,4-difluorophenyl)-4,5-dihydro-5-methyl-N-[(4-methyl-2-morpholinyl)methyl] is an antifibrotic agent.

N-methyl-1H-indole-2-carboxamide (ZINC35137534) is a marine derived natural products found in Neosartorya pseudofischeri.

N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide inhibiting the entry of Ebola virus in host cells by binding to the surface glycoprotein, the compound inhibited the Ebola virus with EC50 of 3.9 μM.

N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide exhibit an inhibitory effect on bacterial DNA helicases, nucleases, or helicase-nuclease enzyme complexes, such as, for example, one or more enzymes selected from the RecBCD and AddAB families of enzymes.

MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

Adenosine-2-carboxamide is a Nucleoside Derivative - 2-Modified purine nucleoside.

(S)-Pyrrolidine-2-carboxamide hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67652 and the CAS number is 42429-27-6.

5-Amino-3H-imidazole-4-Carboxamide (AICA) is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T66203 and the CAS number is 356068-86-5.

5-Chloro-N-methylthiophene-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T64465 and the CAS number is 97799-98-9.

3,6-Difluoropyrazine-2-carboxamide is a useful organic compound for research related to life sciences and the catalog number is T66387.

3-Amino-1H-pyrazole-4-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67506 and the CAS number is 5334-31-6.

(2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67228 and the CAS number is 1416134-49-0.

6-Chloro-3-hydroxypyrazine-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T66158 and the CAS number is 259793-90-3.

(R)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64535.

4-Amino-1-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide is a purine nucleoside analog with broad antitumor activity against indolent lymphoid malignancies. Its anticancer mechanisms involve inhibiting DNA synthesis and inducing apoptosis, among others [1].

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)furan-2-carboxamide hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T66667.

5-(2-Thioxo-2,3-dihydrothiazol-4-yl)thiophene-2-carboxamide is a useful organic compound for research related to life sciences and the catalog number is T64886.

(R)-5-Chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67331 and the CAS number is 721401-53-2.

De(5-carboxamide)oxcarbazepine is used for organic synthesis.

4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67079 and the CAS number is 139756-02-8.

1-Methyl-4-nitro-3-propyl-(1H)-pyrazole-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T65742 and the CAS number is 139756-01-7.

6-Bromo-3-hydroxypyrazine-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T66159 and the CAS number is 259793-88-9.

Acridine-9-carboxamide, 1,2,3,5-tetrahydro-N,N-diethyl- is a biochemcial.

5-Amino-1H-imidazole-4-carboxamide hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67488 and the CAS number is 72-40-2.

10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T66988 and the CAS number is 59690-97-0.

N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T66252 and the CAS number is 90357-51-0.

2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T65317 and the CAS number is 80047-24-1.

(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67699 and the CAS number is 2365497-12-5.

4-Amino-1-(2-b-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide is a Nucleoside Derivative - 7-Deaza-purine nucleoside; 2'-Modified nucleoside.

(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67324 and the CAS number is 900160-98-7.

4-Amino-1-(3-deoxy-3-fluoro-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide is a useful organic compound for research related to life sciences and the catalog number is TNU0278.

4-Amino-1-methyl-3-(2-methylpropyl)-1H-pyrazole-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T64521 and the CAS number is 268204-00-8.

Nucleoside Derivatives - 7-Deaza-purine nucleosides; Natural product; inhibitor of protein kinase C

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin/CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin/CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg/kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg/kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg/kg/day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.

MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1.

ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities.

BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).

Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8

SPOP-IN-6b is an effective inhibitor of speckle-type POZ protein (SPOP) with an IC50 of 3.58 μM and can be used in stuides about the treatment of renal cancer.

CB2 receptor agonist 2 (ZINC72105556) is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.

Iso-Samidorphan is a biochemical reagent that can be used in biological experiments.

3-Amino-4-pyrazolecarboxamide hemisulfate is a useful organic compound for research related to life sciences. The catalog number is T65014 and the CAS number is 27511-79-1.

TRIA-662 (Nicotinamide Chloromethylate) is a niacin metabolite excreted via the urinary system.

4-QUinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- is an amine.