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Autophagy CXCR

CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions. The intracellular second loop is a site that is coupled to a heterotrimeric G-protein and has a characteristic aspartate-arginine-tyrosine box amino acid sequence.
Cat No. product name
T1739 WZ811 WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
T1776 Plerixafor Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
T1776L AMD 3100 octahydrochloride AMD 3100 octahydrochloride blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (...
T1955 SB225002 SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
T2477 UNBS-5162 UNBS-5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
T3047 SRT3109 SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
T3327 Arteether Arteether is a new, fast-acting antimalarial drug.
T3396 Baohuoside I Baohuoside I is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.
T4032 MSX-127 MSX-127 elicites positive response in peptide CXCR4.
T4033 MSX-130 MSX-130 is CXCR4 Antagonist.
T4163 Repertaxin Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR...
T6764 ATI-2341 ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pr...
T3992 MSX-122 MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
T5193 Danirixin Danirixin is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
T5207 LIT-927 LIT-927 is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).
T7130 Navarixin Navarixin(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking i...
T5849 JMS-17-2 JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
T7681 AZD-5069 AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
TQ0174 AMD-070 Mavorixafor (AMD-070) is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-t...
T12269L NUCC-390 dihydrochloride NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
T12269 NUCC-390 NUCC-390 is a selective agonist of small-molecule CXCR4 receptor.
T10905 CXCR2-IN-1 CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
T8497 SX-682 SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
TP2141L Balixafortide Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and pro...
T14665 Motixafortide Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
T12705 Reparixin L-lysine salt Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
T11140 E6130 E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T11179 Elubrixin  Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such ...
TP2141 Balixafortide TFA Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pan...
T10635 Burixafor hydrobromide Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tr...
T19385 ITIC-4F ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs).ITIC-4F is an indacenodithien...
T19386 ITIC ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C. ITIC, non-fullerene acceptor, is an in...
T16850 SB-265610 SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilizat...
T16864 SCH 563705 SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T16933 SRT3190 SRT3190 is an antagonist of CXCR2.
T17208 USL311 USL311 is a selective antagonist of CXCR4. USL311 prevents the binding of stromal-cell derived factor-1 to CXCR4.
TN5227 (+/-)-Vestitol Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential t...
WZ811
T1739CAS 55778-02-4
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
Plerixafor
T1776CAS 110078-46-1
Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
AMD 3100 octahydrochloride
T1776LCAS 155148-31-5
AMD 3100 octahydrochloride blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (...
SB225002
T1955CAS 182498-32-4
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
UNBS-5162
T2477CAS 956590-23-1
UNBS-5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
SRT3109
T3047CAS 1204707-71-0
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
Arteether
T3327CAS 75887-54-6
Arteether is a new, fast-acting antimalarial drug.
Baohuoside I
T3396CAS 113558-15-9
Baohuoside I is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.
MSX-127
T4032CAS 6616-56-4
MSX-127 elicites positive response in peptide CXCR4.
MSX-130
T4033CAS 4051-59-6
MSX-130 is CXCR4 Antagonist.
Repertaxin
T4163CAS 266359-83-5
Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR...
ATI-2341
T6764CAS 1337878-62-2
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pr...
MSX-122
T3992CAS 897657-95-3
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
Danirixin
T5193CAS 954126-98-8
Danirixin is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
LIT-927
T5207CAS 2172879-52-4
LIT-927 is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).
Navarixin
T7130CAS 473727-83-2
Navarixin(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking i...
JMS-17-2
T5849CAS 1380392-05-1
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
AZD-5069
T7681CAS 878385-84-3
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
AMD-070
TQ0174CAS 558447-26-0
Mavorixafor (AMD-070) is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-t...
NUCC-390 dihydrochloride
T12269LCAS
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
NUCC-390
T12269CAS 1060524-97-1
NUCC-390 is a selective agonist of small-molecule CXCR4 receptor.
CXCR2-IN-1
T10905CAS 1873376-49-8
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
SX-682
T8497CAS 1648843-04-2
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
Balixafortide
TP2141LCAS 1051366-32-5
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and pro...
Motixafortide
T14665CAS 664334-36-5
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
Reparixin L-lysine salt
T12705CAS 266359-93-7
Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
E6130
T11140CAS 1427058-33-0
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
Elubrixin
T11179CAS 688763-64-6
 Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such ...
Balixafortide TFA
TP2141CAS
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pan...
Burixafor hydrobromide
T10635CAS 1191450-19-7
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tr...
ITIC-4F
T19385CAS 2097998-59-7
ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs).ITIC-4F is an indacenodithien...
ITIC
T19386CAS 1664293-06-4
ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C. ITIC, non-fullerene acceptor, is an in...
SB-265610
T16850CAS 211096-49-0
SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilizat...
SCH 563705
T16864CAS 473728-58-4
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
SRT3190
T16933CAS 1204707-73-2
SRT3190 is an antagonist of CXCR2.
USL311
T17208CAS 1373268-67-7
USL311 is a selective antagonist of CXCR4. USL311 prevents the binding of stromal-cell derived factor-1 to CXCR4.
(+/-)-Vestitol
TN5227CAS 56701-24-7
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential t...