T1739 |
WZ811 |
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM). |
T1776 |
Plerixafor |
Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4. |
T1776L |
Plerixafor 8HCl (AMD3100 8HCl) |
AMD 3100 octahydrochloride blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (...
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T1955 |
SB225002 |
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2. |
T2477 |
UNBS5162 |
UNBS-5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. |
T3047 |
SRT3109 |
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions. |
T3327 |
Arteether |
Arteether is a new, fast-acting antimalarial drug. |
T3396 |
Baohuoside I |
Baohuoside I is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities. |
T4032 |
MSX127 |
MSX-127 elicites positive response in peptide CXCR4. |
T4033 |
MSX130 |
MSX-130 is CXCR4 Antagonist. |
T4163 |
Repertaxin |
Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks C...
|
T6764 |
ATI2341 |
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pr...
|
T3992 |
MSX122 |
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM). |
T5193 |
Danirixin |
Danirixin is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM). |
T5207 |
LIT927 |
LIT-927 is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4). |
T7130 |
Navarixin |
Navarixin(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking i...
|
T5849 |
JMS-17-2 |
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM). |
T7681 |
AZD-5069 |
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM). |
TQ0174 |
AMD-070 |
Mavorixafor (AMD-070) is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-t...
|
T12269L |
NUCC-390 dihydrochloride |
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor. |
T12269 |
NUCC-390 |
NUCC-390 is a selective agonist of small-molecule CXCR4 receptor. |
T10905 |
CXCR2-IN-1 |
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent. |
T8497 |
SX-682 |
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer. |
TP2141L |
Balixafortide |
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and pro...
|
T14665 |
Motixafortide |
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). |
T12705 |
Reparixin L-lysine salt |
Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor. |
T11140 |
E6130 |
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration. |
T11179 |
Elubrixin |
Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as...
|
TP2141 |
Balixafortide TFA |
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pan...
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T10635 |
Burixafor hydrobromide |
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tr...
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T19385 |
ITIC-4F |
ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs).ITIC-4F is an indacenodithien...
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T19386 |
ITIC |
ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C. ITIC, non-fullerene acceptor, is an in...
|
T16850 |
SB-265610 |
SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilizat...
|
T16864 |
SCH 563705 |
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively). |
T16933 |
SRT3190 |
SRT3190 is an antagonist of CXCR2. |
T17208 |
USL311 |
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation a...
|
TN5227 |
(+/-)-Vestitol |
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential t...
|
TP1348 |
FC131 TFA |
FC131 TFA is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv activity. |
T10297L |
AMG 487 |
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s o...
|
T0801 |
Tannic acid |
Tannic acid is a novel hERG channel blocker. |
T14665L |
Motixafortide TFA(664334-36-5,Free) |
Motixafortide is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via alte...
|
T7499 |
TAK-779 |
TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). |
T22565 |
AMD-070 hydrochloride |
AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV. |