CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.

Cat. No.	Product name	CAS No.	Purity
TP2141L	Balixafortide	1051366-32-5	98%
TP2141L	Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T14665	Motixafortide	664334-36-5	98%
T14665	Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
TP2141	Balixafortide TFA (1051366-32-5 free base)	TP2141	98%
TP2141	Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T19385	ITIC-4F	2097998-59-7	98%
T19385	ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs).ITIC-4F is an indacenodithieno...
T6764	ATI-2341	1337878-62-2	98%
T6764	ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pro...
T19386	ITIC	1664293-06-4	98%
T19386	ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C. ITIC, non-fullerene acceptor, is an inda...
T16864	SCH 563705	473728-58-4	98%
T16864	SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
TN5227	(+/-)-Vestitol	56701-24-7	98%
TN5227	Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
T12269L	NUCC-390 dihydrochloride (1060524-97-1 free base)	T12269L	98%
T12269L	NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
T16933	SRT3190	1204707-73-2	98%
T16933	SRT3190 is an antagonist of CXCR2.
T11140	E6130	1427058-33-0	98%
T11140	E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T10635	Burixafor hydrobromide	1191450-19-7	98%
T10635	Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
TP2051L	CTCE 9908 acetate		98%
TP2051L	CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.
TQ0174	Mavorixafor	558447-26-0	98%
TQ0174	Mavorixafor is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication o...
T9721	ML339	2579689-83-9	98%
T9721	ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
T5849	JMS-17-2	1380392-05-1	98%
T5849	JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
T14665L	Motixafortide TFA(664334-36-5,Free)	T14665L	98%
T14665L	Motixafortide is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered...
T6764L	ATI-2341 acetate(1337878-62-2 free base)	T6764L	98%
T6764L	ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein (G...
T12705	Reparixin L-lysine salt	266359-93-7	98%
T12705	Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
T15805L	LY2510924 acetate(1088715-84-7 free base)	T15805L	98%
T15805L	Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.