CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.

Cat. No.	Product name	CAS No.	Purity
TN5227	(+/-)-Vestitol	56701-24-7	98%
TN5227	Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
TP2141L	Balixafortide	1051366-32-5	98%
TP2141L	Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T11140	E6130	1427058-33-0	98%
T11140	E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T19386	ITIC	1664293-06-4	98%
T19386	ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C. ITIC, non-fullerene acceptor, is an inda...
T10905	CXCR2-IN-1	1873376-49-8	98%
T10905	CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
T14665	Motixafortide	664334-36-5	98%
T14665	Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
T10635	Burixafor hydrobromide	1191450-19-7	98%
T10635	Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
TP2141	Balixafortide TFA (1051366-32-5 free base)	TP2141	98%
TP2141	Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T19385	ITIC-4F	2097998-59-7	98%
T19385	ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs).ITIC-4F is an indacenodithieno...
T16933	SRT3190	1204707-73-2	98%
T16933	SRT3190 is an antagonist of CXCR2.
T12269L	NUCC-390 dihydrochloride (1060524-97-1 free base)	T12269L	98%
T12269L	NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
T6764	ATI-2341	1337878-62-2	98%
T6764	ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pro...
T16864	SCH 563705	473728-58-4	98%
T16864	SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T9721	ML339	2579689-83-9	98%
T9721	ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
T16850	SB-265610	211096-49-0	98%
T16850	SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilizati...
TP2051L	CTCE 9908 acetate		98%
TP2051L	CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.
TQ0174	Mavorixafor	558447-26-0	98%
TQ0174	Mavorixafor is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication o...
TP1364L	ALX 40-4C acetate	TP1364L	98%
TP1364L	ALX 40-4C acetate is a CXCR4 inhibitor of the chemokine receptor (Ki = 1 μM) and suppresses the replication of X4 strains of HIV-1. ALX 40-4C acetate is an antag...
T12269	NUCC-390	1060524-97-1	98%
T12269	NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD31...
T0801	Tannic acid	1401-55-4
T0801	Tannic acid is a novel hERG channel blocker.