T13090L |
TAS4464
|
1848959-10-3
|
98.27%
|
|
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
|
T78194 |
Skp2 inhibitor 2
|
2760612-77-7
|
98%
|
|
Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1. This compound ta...
|
T78221 |
TRAF6 peptide TFA
|
|
98%
|
|
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates prom...
|
T78721 |
Smurf1-IN-1
|
1824708-03-3
|
98%
|
|
Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in...
|
T79133 |
UC-764864
|
278806-03-4
|
98%
|
|
UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in leuke...
|
T79893 |
Cbl-b-IN-6
|
2815221-33-9
|
98%
|
|
Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (I...
|
T79894 |
Cbl-b-IN-7
|
2815221-35-1
|
98%
|
|
Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s)...
|
T79895 |
Cbl-b-IN-8
|
2815223-33-5
|
98%
|
|
Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5....
|
T79896 |
Cbl-b-IN-9
|
2815223-41-5
|
98%
|
|
Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal inhib...
|
T79897 |
Cbl-b-IN-10
|
2815225-12-6
|
98%
|
|
Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s...
|
T79898 |
Cbl-b-IN-11
|
2815225-15-9
|
98%
|
|
Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of 6...
|
T79899 |
Cbl-b-IN-12
|
2851871-29-7
|
98%
|
|
Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100 n...
|
T79900 |
Cbl-b-IN-13
|
2368841-85-2
|
98%
|
|
Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].
|
T2158 |
Nutlin-3
|
548472-68-0
|
99.89%
|
|
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; ind...
|
T16888 |
SJ-172550
|
431979-47-4
|
99.87%
|
|
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
|
T3653 |
MX69
|
1005264-47-0
|
99.78%
|
|
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
|
T6S2123 |
Ginkgolic Acid
|
22910-60-7
|
99.72%
|
|
Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.
|
T25465 |
GS143
|
916232-21-8
|
99.72%
|
|
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and t...
|
T6611 |
NSC697923
|
343351-67-7
|
99.69%
|
|
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cel...
|
T5374 |
NAcM-OPT
|
2089293-61-6
|
99.68%
|
|
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
|