T13090L |
TAS4464
|
1848959-10-3
|
98%
|
|
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
|
T2158 |
Nutlin-3
|
548472-68-0
|
98%
|
|
Nutlin-3 is an MDM2 antagonist. Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; in...
|
T16888 |
SJ-172550
|
431979-47-4
|
98%
|
|
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
|
T3317 |
SZL P1-41
|
222716-34-9
|
98%
|
|
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the act...
|
T25465 |
GS143
|
916232-21-8
|
98%
|
|
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and t...
|
T5374 |
NAcM-OPT
|
2089293-61-6
|
98%
|
|
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
|
T13412 |
ZM223
|
2031177-48-5
|
98%
|
|
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
|
T9236 |
WSB1 Degrader 1
|
2306039-66-5
|
98%
|
|
WSB1 Degrader 1 is a poten and orally active WD repeat and SOCS box-containing 1 degrader. WSB1 Degrader 1 has anticancer metastatic effects
|
T4036 |
Solasodine
|
126-17-0
|
98%
|
|
Solasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity again...
|
T16901 |
SMIP004
|
143360-00-3
|
98%
|
|
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
|
T6149 |
YH239-EE
|
1364488-67-4
|
98%
|
|
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
|
T3110 |
PRT4165
|
31083-55-3
|
98%
|
|
PRT4165 is a potent PRC1-mediated H2A ubiquitylation inhibitor.
|
T6254 |
Idasanutlin
|
1229705-06-9
|
98%
|
|
Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
|
T72043 |
SCFSkp2-IN-2
|
1375060-02-8
|
98%
|
|
SCFSkp2-IN-2 is a Skp2 inhibitor with a K D of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .
|
T24136 |
Heclin
|
890605-54-6
|
98%
|
|
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
|
T6332 |
Pevonedistat
|
905579-51-3
|
98%
|
|
MLN4924 is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).
|
T8564 |
BC-1382
|
1013753-99-5
|
98%
|
|
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
|
T8929 |
BC1618
|
2222094-18-8
|
98%
|
|
BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
|
T3549 |
Avadomide
|
1015474-32-4
|
98%
|
|
CC-122 is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
|
T63790 |
Cbl-b-IN-3
|
2573775-59-2
|
98%
|
|
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in...
|