E1/E2/E3 Enzyme

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

Cat. No.	Product name	CAS No.	Purity
T13090L	TAS4464	1848959-10-3	98%
T13090L	TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
T2158	Nutlin-3	548472-68-0	98%
T2158	Nutlin-3 is an MDM2 antagonist. Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; in...
T16888	SJ-172550	431979-47-4	98%
T16888	SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T3317	SZL P1-41	222716-34-9	98%
T3317	SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the act...
T25465	GS143	916232-21-8	98%
T25465	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and t...
T5374	NAcM-OPT	2089293-61-6	98%
T5374	NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).
T13412	ZM223	2031177-48-5	98%
T13412	ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
T9236	WSB1 Degrader 1	2306039-66-5	98%
T9236	WSB1 Degrader 1 is a poten and orally active WD repeat and SOCS box-containing 1 degrader. WSB1 Degrader 1 has anticancer metastatic effects
T4036	Solasodine	126-17-0	98%
T4036	Solasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity again...
T16901	SMIP004	143360-00-3	98%
T16901	SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
T6149	YH239-EE	1364488-67-4	98%
T6149	YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
T3110	PRT4165	31083-55-3	98%
T3110	PRT4165 is a potent PRC1-mediated H2A ubiquitylation inhibitor.
T6254	Idasanutlin	1229705-06-9	98%
T6254	Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T72043	SCFSkp2-IN-2	1375060-02-8	98%
T72043	SCFSkp2-IN-2 is a Skp2 inhibitor with a K D of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .
T24136	Heclin	890605-54-6	98%
T24136	Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
T6332	Pevonedistat	905579-51-3	98%
T6332	MLN4924 is an effective and specific small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50: 4.7 nM).
T8564	BC-1382	1013753-99-5	98%
T8564	BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
T8929	BC1618	2222094-18-8	98%
T8929	BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
T3549	Avadomide	1015474-32-4	98%
T3549	CC-122 is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
T63790	Cbl-b-IN-3	2573775-59-2	98%
T63790	Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in...