T63790 |
Cbl-b-IN-3
|
2573775-59-2
|
98%
|
|
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in...
|
TQ0127 |
Navtemadlin
|
1352066-68-2
|
98%
|
|
AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
|
T5374 |
NAcM-OPT
|
2089293-61-6
|
98%
|
|
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
|
T6585 |
SAR405838
|
1303607-60-4
|
98%
|
|
MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
|
T9500 |
M435-1279
|
1359431-16-5
|
98%
|
|
M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.
|
T16102 |
ML-792
|
1644342-14-2
|
98%
|
|
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μ...
|
T16699 |
PYZD-4409
|
423148-78-1
|
98%
|
|
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells...
|
T16901 |
SMIP004
|
143360-00-3
|
98%
|
|
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
|
T12261 |
NSC232003
|
1905453-18-0
|
|
|
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.
|
T5555 |
Siremadlin
|
1448867-41-1
|
|
|
Siremadlin is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.
|
T8428 |
Subasumstat
|
1858276-04-6
|
|
|
TAK-981 is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
|
T6149 |
YH239-EE
|
1364488-67-4
|
100%
|
|
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
|
T11980 |
MD-224
|
2136247-12-4
|
100%
|
|
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
|
T7889 |
C25-140
|
1358099-18-9
|
100%
|
|
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
|
T5199 |
COH000
|
1534358-79-6
|
96.91%
|
|
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
|
T2947 |
Indole-3-carbinol
|
700-06-1
|
97.06%
|
|
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
|
T10703 |
Mezigdomide
|
2259648-80-9
|
97.21%
|
|
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.
|
T2243 |
Serdemetan
|
881202-45-5
|
98%
|
|
Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
|
T7379 |
2-D08
|
144707-18-6
|
98%
|
|
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
|
T1493 |
BH3I-1
|
300817-68-9
|
98.2%
|
|
BH3I-1 is a Bcl-2 antagonist.
|