HIF

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.

Cat. No.	Product name	CAS No.	Purity
T12675	(Rac)-PT2399	1672662-07-5	98%
T12675	(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
TN2040	Panaxynol	81203-57-8	98%
TN2040	Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
T13402	ZK-261991	886563-25-3	98%
T13402	ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
TN4603	Myricanol	33606-81-4	98%
TN4603	Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
T6804	Chetomin	1403-36-7	98%
T6804	Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
TN1951	Moracin O	123702-97-6	98%
TN1951	Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9...
T15234	ENMD-1198	864668-87-1	98%
T15234	ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T10258	AFP464 free base	468719-52-0	98%
T10258	AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
TN4489	Manassantin A	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN5250	Vomifoliol	23526-45-6	98%
TN5250	Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
TN1952	Moracin P	102841-46-3	98%
TN1952	Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
T17009	TC-S 7009	1422955-31-4	98%
T17009	TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd 5 μM). TC-S 7009 is an effective and selective inhibitor of HIF-2α (Kd: 81 nM). TC-S 7009 disrupts HIF-2...
T11562	HIF-2α-IN-3	313964-19-1	98%
T11562	HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 µM; KD: 1.1 µM) with anticancer activity.
TN2250	Syringaresinol	487-35-4	98%
TN2250	(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation ...
T29797	AKB-6899	1007377-55-0	98%
T29797	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T19832	Acriflavine Hydrochloride	8063-24-9	98%
T19832	Acriflavine Hydrochloride is a HIF-1α inhibitor. It acts by targeting HIF-1α-mediated pathways and decreasing the level of PGK1, VEGF, and HIF-1α in vitro and in...
T22022	Adaptaquin	385786-48-1	98%
T22022	Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
T10233	Acetylarenobufagin	184673-79-8	98%
T10233	Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
T11589	Hydroxycitric acid tripotassium hydrate	6100-05-6
T11589	Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
T13925	THS-044	62054-67-5	100%
T13925	THS-044 binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity in endogenous and clinical settings.