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Angiogenesis HIF

HIF

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.
Cat No. product name
T0447 Carvedilol Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
T1939 DMOG DMOG, an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T2220 2-Methoxyestradiol 2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
T2488 BAY 87-2243 BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T2515 Roxadustat Roxadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.
T3027 Sodium Aescinate Sodium Aescinate is extracted from Aesculus wilsonii.
T3169 KC7F2 KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T3197 Daprodustat Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.
T3404 Cucurbitacin B Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-re...
T3494 LW6 LW6 is a novel HIF-1 inhibitor.
T6929 Pantoprazole sodium Pantoprazole Sodium is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole is a lipophilic, weak base that cro...
T6961 PX-478 2HCl PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
T4381 Lificiguat YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T4106 MK-8617 MK-8617 is an orally available HIF PHD1-3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
T4S1551 Cinnamaldehyde 1. Cinnamaldehyde has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was co...
T4651 Vadadustat Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.
T4S0800 Demethyleneberberine Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either...
T5537 IDF-11774 IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T7692 2,4-DPD 2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
T7848 PT-2385 PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T7802 M1001 M1001 is a HIF-2α agonist.
T0153 Oltipraz Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as ...
TN1480 Cephaeline Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox ho...
TN1951 Moracin O Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H...
TN2250 Syringaresinol (-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation...
TN1507 Clematichinenoside AR Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associ...
TN1952 Moracin P Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tu...
TN2040 Panaxynol Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
T12675 (Rac)-PT2399 (Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
T10258 AFP464 free base AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
T15234 ENMD-119 ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T15396 GN44028 GN44028 is an inhibitor of HIF-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mR...
T13050 SYP-5 SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T11561 HIF-2α-IN-2 HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor, has an IC50 of 16 nM in scintillation proximity assay . 
T11562 HIF-2α-IN-3 HIF-2α-IN-3, Anticancer agent. an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. 
T13402 ZK-261991 ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
T12675L PT2399 PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC...
T16679 PT2977 PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). PT2977, as...
T17009 TC-S 7009 TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 is an effective and selective inhibitor of HIF-2α (Kd: 81 nM). TC-S 7009 disrupt...
TN4489 Manassantin A Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
TN4603 Myricanol Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
TN5250 Vomifoliol Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major...
Carvedilol
T0447CAS 72956-09-3
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
DMOG
T1939CAS 89464-63-1
DMOG, an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
2-Methoxyestradiol
T2220CAS 362-07-2
2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
BAY 87-2243
T2488CAS 1227158-85-1
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
Roxadustat
T2515CAS 808118-40-3
Roxadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.
Sodium Aescinate
T3027CAS 20977-05-3
Sodium Aescinate is extracted from Aesculus wilsonii.
KC7F2
T3169CAS 927822-86-4
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
Daprodustat
T3197CAS 960539-70-2
Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.
Cucurbitacin B
T3404CAS 6199-67-3
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-re...
LW6
T3494CAS 934593-90-5
LW6 is a novel HIF-1 inhibitor.
Pantoprazole sodium
T6929CAS 138786-67-1
Pantoprazole Sodium is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole is a lipophilic, weak base that cro...
PX-478 2HCl
T6961CAS 685898-44-6
PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
Lificiguat
T4381CAS 170632-47-0
YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
MK-8617
T4106CAS 1187990-87-9
MK-8617 is an orally available HIF PHD1-3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
Cinnamaldehyde
T4S1551CAS 104-55-2
1. Cinnamaldehyde has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was co...
Vadadustat
T4651CAS 1000025-07-9
Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.
Demethyleneberberine
T4S0800CAS 25459-91-0
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either...
IDF-11774
T5537CAS 1429054-28-3
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
2,4-DPD
T7692CAS 41438-38-4
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
PT-2385
T7848CAS 1672665-49-4
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
M1001
T7802CAS 874590-32-6
M1001 is a HIF-2α agonist.
Oltipraz
T0153CAS 64224-21-1
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as ...
Cephaeline
TN1480CAS 483-17-0
Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox ho...
Moracin O
TN1951CAS 123702-97-6
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H...
Syringaresinol
TN2250CAS 487-35-4
(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation...
Clematichinenoside AR
TN1507CAS 761425-93-8
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associ...
Moracin P
TN1952CAS 102841-46-3
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tu...
Panaxynol
TN2040CAS 81203-57-8
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
(Rac)-PT2399
T12675CAS 1672662-07-5
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
AFP464 free base
T10258CAS 468719-52-0
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
ENMD-119
T15234CAS 864668-87-1
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
GN44028
T15396CAS 1421448-26-1
GN44028 is an inhibitor of HIF-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mR...
SYP-5
T13050CAS 1384268-04-5
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
HIF-2α-IN-2
T11561CAS 1672666-82-8
HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor, has an IC50 of 16 nM in scintillation proximity assay . 
HIF-2α-IN-3
T11562CAS 313964-19-1
HIF-2α-IN-3, Anticancer agent. an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. 
ZK-261991
T13402CAS 886563-25-3
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
PT2399
T12675LCAS 1672662-14-4
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC...
PT2977
T16679CAS 1672668-24-4
PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). PT2977, as...
TC-S 7009
T17009CAS 1422955-31-4
TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 is an effective and selective inhibitor of HIF-2α (Kd: 81 nM). TC-S 7009 disrupt...
Manassantin A
TN4489CAS 88497-87-4
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
Myricanol
TN4603CAS 33606-81-4
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
Vomifoliol
TN5250CAS 23526-45-6
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major...