T12675 |
(Rac)-PT2399
|
1672662-07-5
|
98%
|
|
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
|
TN2040 |
Panaxynol
|
81203-57-8
|
98%
|
|
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
|
T13402 |
ZK-261991
|
886563-25-3
|
98%
|
|
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
|
TN4603 |
Myricanol
|
33606-81-4
|
98%
|
|
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
|
T6804 |
Chetomin
|
1403-36-7
|
98%
|
|
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
|
TN1951 |
Moracin O
|
123702-97-6
|
98%
|
|
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9...
|
T15234 |
ENMD-1198
|
864668-87-1
|
98%
|
|
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
|
T10258 |
AFP464 free base
|
468719-52-0
|
98%
|
|
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
|
TN4489 |
Manassantin A
|
88497-87-4
|
98%
|
|
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
|
TN5250 |
Vomifoliol
|
23526-45-6
|
98%
|
|
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
|
TN1952 |
Moracin P
|
102841-46-3
|
98%
|
|
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
|
T17009 |
TC-S 7009
|
1422955-31-4
|
98%
|
|
TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd 5 μM). TC-S 7009 is an effective and selective inhibitor of HIF-2α (Kd: 81 nM). TC-S 7009 disrupts HIF-2...
|
T11562 |
HIF-2α-IN-3
|
313964-19-1
|
98%
|
|
HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 µM; KD: 1.1 µM) with anticancer activity.
|
TN2250 |
Syringaresinol
|
487-35-4
|
98%
|
|
(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation ...
|
T29797 |
AKB-6899
|
1007377-55-0
|
98%
|
|
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
|
T19832 |
Acriflavine Hydrochloride
|
8063-24-9
|
98%
|
|
Acriflavine Hydrochloride is a HIF-1α inhibitor. It acts by targeting HIF-1α-mediated pathways and decreasing the level of PGK1, VEGF, and HIF-1α in vitro and in...
|
T22022 |
Adaptaquin
|
385786-48-1
|
98%
|
|
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
|
T10233 |
Acetylarenobufagin
|
184673-79-8
|
98%
|
|
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
|
T11589 |
Hydroxycitric acid tripotassium hydrate
|
6100-05-6
|
|
|
Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
|
T13925 |
THS-044
|
62054-67-5
|
100%
|
|
THS-044 binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity in endogenous and clinical settings.
|