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RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.
Cat No. product name
T12493 PK68 PK68 是 II 型受体相互作用激酶 1 (RIPK1, IC50 = 90 nM) 的有效特异性抑制剂。 PK68可用于治疗炎症性疾病和癌症转移的研究。
T4074L GSK872 HCl(1346546-69-7 free base) GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: ...
T7795 RIPA-56 RIPA-56 is an inhibitor of RIP1
T7151 GSK2982772 GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T15437 GSK3145095 GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
T5054 GSK963 GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T8931L ICCB-19 HCl(750621-52-4 free base) ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
T6852 GSK481 GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
T3537 GSK583 GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T9702 Eclitasertib Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
T7397 GSK547 GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
T2048 LY-364947 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T1847 Necrostatin-1 Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T9072 Tuxobertinib BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
T3997 WEHI-345 WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
T12731 RIPK1-IN-7 RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
T6815 HS-1371 HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T4074 GSK-872 GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
T11501 GSK840 GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
T9095 Necrostatin-34 Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
T9305 Necroptosis-IN-1 Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T7504 Necrostatin 2 racemate Necrostatin 2 racemate is an potent and specific inhibitor of RIPK1.
T5401 GSK2983559 active metabolite GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
T11492 GSK2983559 free acid GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品和体内的许多促炎细胞因子反应方面表现出优异的活性。
PK68
T12493
PK68 是 II 型受体相互作用激酶 1 (RIPK1, IC50 = 90 nM) 的有效特异性抑制剂。 PK68可用于治疗炎症性疾病和癌症转移的研究。
GSK872 HCl(1346546-69-7 free base)
T4074L
GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: ...
RIPA-56
T7795
RIPA-56 is an inhibitor of RIP1
GSK2982772
T7151
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
GSK3145095
T15437
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
GSK963
T5054
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
ICCB-19 HCl(750621-52-4 free base)
T8931L
ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
GSK481
T6852
GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
GSK583
T3537
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
Eclitasertib
T9702
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
GSK547
T7397
GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
LY-364947
T2048
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
Necrostatin-1
T1847
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
Tuxobertinib
T9072
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
WEHI-345
T3997
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
RIPK1-IN-7
T12731
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
HS-1371
T6815
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
GSK-872
T4074
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
GSK840
T11501
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
Necrostatin-34
T9095
Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
Necroptosis-IN-1
T9305
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
Necrostatin 2 racemate
T7504
Necrostatin 2 racemate is an potent and specific inhibitor of RIPK1.
GSK2983559 active metabolite
T5401
GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
GSK2983559 free acid
T11492
GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品...