T12730 |
RIPK1-IN-4
|
1481641-08-0
|
98%
|
|
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
|
T63055 |
RIPK1-IN-9
|
2682889-57-0
|
98%
|
|
RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...
|
T24152 |
HTH-01-091
|
2000209-42-5
|
98%
|
|
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
|
T12728 |
RIP2 Kinase Inhibitor 3
|
1398053-50-3
|
98%
|
|
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
|
T11484 |
GSK2593074A
|
1337531-06-2
|
98%
|
|
GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
|
T61424 |
OD36 hydrochloride
|
2387510-88-3
|
98%
|
|
OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
|
T3997 |
WEHI-345
|
1354825-58-3
|
98%
|
|
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
|
T4074L |
GSK872 HCl(1346546-69-7 free base)
|
2703752-81-0
|
98%
|
|
GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: ...
|
T1847 |
Necrostatin-1
|
4311-88-0
|
98%
|
|
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
|
T6852 |
GSK481
|
1622849-58-4
|
98%
|
|
GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
|
T2048 |
LY-364947
|
396129-53-6
|
98%
|
|
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
|
T11501 |
GSK840
|
2361146-30-5
|
98%
|
|
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
|
T4074 |
GSK-872
|
1346546-69-7
|
98%
|
|
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
|
T9305 |
Necroptosis-IN-1
|
1391980-92-9
|
98%
|
|
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
|
T8931L |
ICCB-19 hydrochloride
|
1803605-68-6
|
98%
|
|
ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
|
T7151 |
GSK2982772
|
1622848-92-3
|
98%
|
|
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
|
T9072 |
Tuxobertinib
|
2414572-47-5
|
98%
|
|
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
|
T3537 |
GSK583
|
1346547-00-9
|
98%
|
|
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
|
T11492 |
GSK2983559 free acid
|
1579965-12-0
|
98%
|
|
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
|
T12493 |
PK68
|
2173556-69-7
|
98%
|
|
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
|