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RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.
Cat. No. Product name CAS No. Purity Chemical Structure
T12730 RIPK1-IN-4 1481641-08-0 98%
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
T63055 RIPK1-IN-9 2682889-57-0 98%
RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...
T24152 HTH-01-091 2000209-42-5 98%
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T12728 RIP2 Kinase Inhibitor 3 1398053-50-3 98%
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
T11484 GSK2593074A 1337531-06-2 98%
GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T61424 OD36 hydrochloride 2387510-88-3 98%
OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
T3997 WEHI-345 1354825-58-3 98%
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
T4074L GSK872 HCl(1346546-69-7 free base) 2703752-81-0 98%
GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: ...
T1847 Necrostatin-1 4311-88-0 98%
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T6852 GSK481 1622849-58-4 98%
GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
T2048 LY-364947 396129-53-6 98%
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T11501 GSK840 2361146-30-5 98%
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
T4074 GSK-872 1346546-69-7 98%
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
T9305 Necroptosis-IN-1 1391980-92-9 98%
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T8931L ICCB-19 hydrochloride 1803605-68-6 98%
ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
T7151 GSK2982772 1622848-92-3 98%
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T9072 Tuxobertinib 2414572-47-5 98%
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
T3537 GSK583 1346547-00-9 98%
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T11492 GSK2983559 free acid 1579965-12-0 98%
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
T12493 PK68 2173556-69-7 98%
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
RIPK1-IN-4
T12730
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
RIPK1-IN-9
T63055
RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...
HTH-01-091
T24152
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
RIP2 Kinase Inhibitor 3
T12728
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
GSK2593074A
T11484
GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
OD36 hydrochloride
T61424
OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
WEHI-345
T3997
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
GSK872 HCl(1346546-69-7 free base)
T4074L
GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: ...
Necrostatin-1
T1847
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
GSK481
T6852
GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
LY-364947
T2048
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
GSK840
T11501
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
GSK-872
T4074
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
Necroptosis-IN-1
T9305
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
ICCB-19 hydrochloride
T8931L
ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
GSK2982772
T7151
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
Tuxobertinib
T9072
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
GSK583
T3537
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
GSK2983559 free acid
T11492
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
PK68
T12493
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
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