RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.

Cat. No.	Product name	CAS No.	Purity
T12730	RIPK1-IN-4	1481641-08-0	98%
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
T12728	RIP2 Kinase Inhibitor 3	1398053-50-3	98%
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
T4074	GSK-872	1346546-69-7	98%
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
T11501	GSK840	2361146-30-5	98%
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
T11492	GSK2983559 free acid	1579965-12-0	98%
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
T12493	PK68	2173556-69-7	98%
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
T9702	Eclitasertib	2125450-76-0	98%
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
T7397	GSK547	2226735-55-1
GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
T15437	GSK3145095	1622849-43-7	100%
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
T6815	HS-1371	2158197-70-5	98%
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T7795	RIPA-56	1956370-21-0	98.45%
RIPA-56 is an inhibitor of RIP1
T9095	Necrostatin-34	375835-43-1	98.47%
Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
T5401	GSK2983559 active metabolite	1423186-80-4	98.48%
GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
T3537	GSK583	1346547-00-9	98.67%
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T5054	GSK963	2049868-46-2	98.68%
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T9072	Tuxobertinib	2414572-47-5	98.86%
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
T7151	GSK2982772	1622848-92-3	99%
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T8931L	ICCB-19 hydrochloride	1803605-68-6	99.23%
ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
T9305	Necroptosis-IN-1	1391980-92-9	99.60%
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T7504	Necrostatin 2 racemate	852391-15-2	99.69%
Necrostatin 2 racemate is an potent and specific inhibitor of RIPK1.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T12730

RIPK1-IN-4

1481641-08-0

98%

RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...

T12728

RIP2 Kinase Inhibitor 3

1398053-50-3

98%

RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.

T4074

GSK-872

1346546-69-7

98%

GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...

T11501

GSK840

2361146-30-5

98%

GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...

T11492

GSK2983559 free acid

1579965-12-0

98%

GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...

T12493

PK68

2173556-69-7

98%

PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...

T9702

Eclitasertib

2125450-76-0

98%

Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).

T7397

GSK547

2226735-55-1

GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.

T15437

GSK3145095

1622849-43-7

100%

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.

T6815

HS-1371

2158197-70-5

98%

HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.

T7795

RIPA-56

1956370-21-0

98.45%

RIPA-56 is an inhibitor of RIP1

T9095

Necrostatin-34

375835-43-1

98.47%

Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.

T5401

GSK2983559 active metabolite

1423186-80-4

98.48%

GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.

T3537

GSK583

1346547-00-9

98.67%

GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).

T5054

GSK963

2049868-46-2

98.68%

GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).

T9072

Tuxobertinib

2414572-47-5

98.86%

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...

T7151

GSK2982772

1622848-92-3

99%

GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.

T8931L

ICCB-19 hydrochloride

1803605-68-6

99.23%

ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...

T9305

Necroptosis-IN-1

1391980-92-9

99.60%