RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.

Cat. No.	Product name	CAS No.	Purity
T12730	RIPK1-IN-4	1481641-08-0	98%
T12730	RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
T63055	RIPK1-IN-9	2682889-57-0	98%
T63055	RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...
T24152	HTH-01-091	2000209-42-5	98%
T24152	HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T12728	RIP2 Kinase Inhibitor 3	1398053-50-3	98%
T12728	RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
T11484	GSK2593074A	1337531-06-2	98%
T11484	GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T61424	OD36 hydrochloride	2387510-88-3	98%
T61424	OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
T3997	WEHI-345	1354825-58-3	98%
T3997	WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
T4074L	GSK872 HCl（1346546-69-7 free base）	2703752-81-0	98%
T4074L	GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: ...
T1847	Necrostatin-1	4311-88-0	98%
T1847	Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T6852	GSK481	1622849-58-4	98%
T6852	GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
T2048	LY-364947	396129-53-6	98%
T2048	LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T11501	GSK840	2361146-30-5	98%
T11501	GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC5...
T4074	GSK-872	1346546-69-7	98%
T4074	GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...
T9305	Necroptosis-IN-1	1391980-92-9	98%
T9305	Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T8931L	ICCB-19 hydrochloride	1803605-68-6	98%
T8931L	ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
T7151	GSK2982772	1622848-92-3	98%
T7151	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T9072	Tuxobertinib	2414572-47-5	98%
T9072	BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
T3537	GSK583	1346547-00-9	98%
T3537	GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T11492	GSK2983559 free acid	1579965-12-0	98%
T11492	GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
T12493	PK68	2173556-69-7	98%
T12493	PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...