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Chromatin/Epigenetic Sirtuin

Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2',the gene responsible for cellular regulation in yeast.
Cat No. product name
T0934 Nicotinamide Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue an...
T1558 ResveratrolHOT Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T1818 Tenovin-6 Tenovin-6 is a p53 transcriptional activity agonist.
T1873 Tenovin-3 Tenovin-3 is a p53 activator.
T1887 Inauhzin Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without...
T2412 SRT1720 hydrochlorideHOT SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
T2879 Fisetin Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins.
T3447 Thiomyristoyl Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T3953 Salermide Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T4019 Cambinol Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
T4062 CAY10602 CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific ...
T4108 3-TYP 3-TYP is a selective SIRT3 inhibitor.
T6111 SelisistatHOT EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
T6371 AGK2 AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
T6671 Sirtinol Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T6678 Splitomicin Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
T6679 SRT2104 SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T6984 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
T4328 OSS_128167 OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T5096 SRT 1720 SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
T5124 SRT 1720 dihydrochloride[925434-55-5(free base)] SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
T2S0300 Hydrocoumarin Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wi...
T5490 AK-7 AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models.with an IC50 of 15.5 μM
T5725 lithospermic acid B lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant...
T6220 Nicotinamide riboside chloride Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine d...
T5618 AK-1 AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 M).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in ...
T7679 UBCS039 UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
TN1071 Ophiopogonin D' Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10.
TN1296 5-O-Feruloylquinic acid 5-O-feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associate...
TN2249 (+)-Syringaresinol (+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
T8346 SRT1460 SRT1460 is a SIRT1 activator.
T13795 Nicotinamide riboside Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-i...
T16667 PROTAC Sirt2 Degrader-1 PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a ...
T15263 Selisistat R-enantiomer Selisistat R-enantiomer is much less active R-enantiomer of Selisistat (IC50 of > 100 μM for SIRT1).
T12918 SIRT-IN-1 SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
T12919 SIRT-IN-2 SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 4, 7 μM, respectively).
T12920 Sirt2-IN-1 Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
T13001 SRT3657 SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
T16932 SRT 2183 SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
Nicotinamide
T0934CAS 98-92-0
Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue an...
Resveratrol HOT
T1558CAS 501-36-0
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Tenovin-6
T1818CAS 1011557-82-6
Tenovin-6 is a p53 transcriptional activity agonist.
Tenovin-3
T1873CAS 1011301-27-1
Tenovin-3 is a p53 activator.
Inauhzin
T1887CAS 309271-94-1
Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without...
SRT1720 hydrochloride HOT
T2412CAS 1001645-58-4
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
Fisetin
T2879CAS 528-48-3
Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins.
Thiomyristoyl
T3447CAS 1429749-41-6
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
Salermide
T3953CAS 1105698-15-4
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
Cambinol
T4019CAS 14513-15-6
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
CAY10602
T4062CAS 374922-43-7
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific ...
3-TYP
T4108CAS 120241-79-4
3-TYP is a selective SIRT3 inhibitor.
Selisistat HOT
T6111CAS 49843-98-3
EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
AGK2
T6371CAS 304896-28-4
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
Sirtinol
T6671CAS 410536-97-9
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
Splitomicin
T6678CAS 5690-03-9
Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
SRT2104
T6679CAS 1093403-33-8
SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
SirReal2
T6984CAS 709002-46-0
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
OSS_128167
T4328CAS 887686-02-4
OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
SRT 1720
T5096CAS 925434-55-5
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
SRT 1720 dihydrochloride[925434-55-5(free base)]
T5124CAS T5124
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
Hydrocoumarin
T2S0300CAS 119-84-6
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wi...
AK-7
T5490CAS 420831-40-9
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models.with an IC50 of 15.5 μM
lithospermic acid B
T5725CAS 121521-90-2
lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant...
Nicotinamide riboside chloride
T6220CAS 23111-00-4
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine d...
AK-1
T5618CAS 330461-64-8
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 M).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in ...
UBCS039
T7679CAS 358721-70-7
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
Ophiopogonin D'
TN1071CAS 65604-80-0
Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10.
5-O-Feruloylquinic acid
TN1296CAS 40242-06-6
5-O-feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associate...
(+)-Syringaresinol
TN2249CAS 21453-69-0
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
SRT1460
T8346CAS 925432-73-1
SRT1460 is a SIRT1 activator.
Nicotinamide riboside
T13795CAS 1341-23-7
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-i...
PROTAC Sirt2 Degrader-1
T16667CAS 2098487-75-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a ...
Selisistat R-enantiomer
T15263CAS 848193-69-1
Selisistat R-enantiomer is much less active R-enantiomer of Selisistat (IC50 of > 100 μM for SIRT1).
SIRT-IN-1
T12918CAS 1431411-60-7
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
SIRT-IN-2
T12919CAS 1431411-66-3
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 4, 7 μM, respectively).
Sirt2-IN-1
T12920CAS 1862238-00-3
Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
SRT3657
T13001CAS 1383551-17-4
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
SRT 2183
T16932CAS 1001908-89-9
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).