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Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
Cat No. product name
T3888 Scopolin Scopolin formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis...
T4019 Cambinol Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-,...
T39233 SIRT7 inhibitor 97491 SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
T4S1173 Agrimol B 1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T6678 Splitomicin Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
T6371 AGK2 AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
T1919 Tenovin-1 Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T1818 Tenovin-6 Tenovin-6 is a p53 transcriptional activity agonist.
T3953 Salermide Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T6671 Sirtinol Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T4328 OSS_128167 OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T2160 Suramin Sodium Salt Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
T3S0175 Gardenia yellow Kuchinashi yellow has anti atherosclerosis and hypolipidemic effects.
T0934 Nicotinamide Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and...
TN1296 5-Feruloylquinic acid 5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
TN7093 N-Caffeoyltryptophan N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 3...
T2750 Ginkgolide C Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
T8480 Tenovin-6 Hydrochloride Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
T16932 SRT 2183 SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T5S1133 Ganoderic acid D 1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervi...
T7679 UBCS039 UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T5725 Salvianolic acid B lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant,...
T1558 Resveratrol Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T2879 Fisetin Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
T5096 SRT 1720 SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
T6220 Nicotinamide riboside chloride Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine di...
T35347 Et-29 NRD167 是一种有效的选择性SIRT5抑制剂。
T7058 Selisistat S-enantiomer EX-527 S-enantiomer is the S-enantiomer of EX-527, with an IC50 of 123 nM for SIRT1. EX-527 S-enantiomer is much more potent than EX-527 R-enantiomer.
T50080 MC2184 MC2184 is the inhibitor of human recombinant SIRT1.
T2S0300 Dihydrocoumarin Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wit...
T1873 Tenovin-3 Tenovin-3 is a p53 activator.
T1887 Inauhzin Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without ...
T21679 4'-bromo-Resveratrol 4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
T2412 SRT1720 hydrochloride SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
TN1071 Ophiopogonin D' Ophiopogonin D'可以以剂量依赖性方式激活 SIRT1。 Ophiopogonin D'也非竞争性地抑制 UGT1A6 和 UGT1A10。
TN2249 (+)-Syringaresinol (+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
T8346 SRT 1460 SRT1460 is a SIRT1 activator.
T9106 E1231 E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
T9320 YK-3-237 YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
T13001 SRT3657 SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
T12919 SIRT-IN-2 SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
T12918 SIRT-IN-1 SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
T12920 Sirt2-IN-1 Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
T6984 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
T3447 Thiomyristoyl Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T4062 CAY10602 CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
T4108 3-TYP 3-TYP is a selective SIRT3 inhibitor.
T6111 Selisistat EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
T6679 SRT 2104 SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T5124 SRT 1720 dihydrochloride[925434-55-5(free base)] SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
Scopolin
T3888
Scopolin formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis...
Cambinol
T4019
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
SIRT7 inhibitor 97491
T39233
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Agrimol B
T4S1173
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
Splitomicin
T6678
Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
AGK2
T6371
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
Tenovin-1
T1919
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
Tenovin-6
T1818
Tenovin-6 is a p53 transcriptional activity agonist.
Salermide
T3953
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
Sirtinol
T6671
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
OSS_128167
T4328
OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
Suramin Sodium Salt
T2160
Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
Gardenia yellow
T3S0175
Kuchinashi yellow has anti atherosclerosis and hypolipidemic effects.
Nicotinamide
T0934
Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and...
5-Feruloylquinic acid
TN1296
5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
N-Caffeoyltryptophan
TN7093
N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; ...
Ginkgolide C
T2750
Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
Tenovin-6 Hydrochloride
T8480
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pote...
SRT 2183
T16932
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
Ganoderic acid D
T5S1133
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervi...
UBCS039
T7679
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
Salvianolic acid B
T5725
lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant,...
Resveratrol
T1558
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Fisetin
T2879
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
SRT 1720
T5096
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
Nicotinamide riboside chloride
T6220
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine di...
Et-29
T35347
NRD167 是一种有效的选择性SIRT5抑制剂。
Selisistat S-enantiomer
T7058
EX-527 S-enantiomer is the S-enantiomer of EX-527, with an IC50 of 123 nM for SIRT1. EX-527 S-enantiomer is much more potent than EX-527 R-enantiomer.
MC2184
T50080
MC2184 is the inhibitor of human recombinant SIRT1.
Dihydrocoumarin
T2S0300
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wit...
Tenovin-3
T1873
Tenovin-3 is a p53 activator.
Inauhzin
T1887
Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without ...
4'-bromo-Resveratrol
T21679
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
SRT1720 hydrochloride
T2412
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
Ophiopogonin D'
TN1071
Ophiopogonin D'可以以剂量依赖性方式激活 SIRT1。 Ophiopogonin D'也非竞争性地抑制 UGT1A6 和 UGT1A10。
(+)-Syringaresinol
TN2249
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
SRT 1460
T8346
SRT1460 is a SIRT1 activator.
E1231
T9106
E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
YK-3-237
T9320
YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
SRT3657
T13001
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
SIRT-IN-2
T12919
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
SIRT-IN-1
T12918
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
Sirt2-IN-1
T12920
Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
SirReal2
T6984
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Thiomyristoyl
T3447
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
CAY10602
T4062
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
3-TYP
T4108
3-TYP is a selective SIRT3 inhibitor.
Selisistat
T6111
EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
SRT 2104
T6679
SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
SRT 1720 dihydrochloride[925434-55-5(free base)]
T5124
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
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