Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.

Cat. No.	Product name	CAS No.	Purity
T16667	PROTAC Sirt2 Degrader-1	2098487-75-1	98%
T16667	PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
T33663	Nicotinamide Riboside Triflate	445489-49-6	98%
T33663	Nicotinamide Riboside Triflate is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat die...
T13001	SRT3657	1383551-17-4	98%
T13001	SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
TN2249	(+)-Syringaresinol	21453-69-0	98%
TN2249	(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
T1558	Resveratrol	501-36-0	99.9%
T1558	Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T4S1173	Agrimol B	55576-66-4	99.89%
T4S1173	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T3888	Scopolin	531-44-2	99.87%
T3888	Scopolin formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis...
T6679	SRT 2104	1093403-33-8	99.83%
T6679	SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T39233	SIRT7 inhibitor 97491	1807758-81-1	99.79%
T39233	SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
T15263	Selisistat R-enantiomer	848193-69-1	99.78%
T15263	Selisistat R-enantiomer is much less active R-enantiomer of Selisistat (IC50 of > 100 μM for SIRT1).
T5725	Salvianolic acid B	121521-90-2	99.76%
T5725	lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant,...
T6671	Sirtinol	410536-97-9	99.75%
T6671	Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T7679	UBCS039	358721-70-7	99.75%
T7679	UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T5096	SRT 1720	925434-55-5	99.7%
T5096	SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
T2412	SRT1720 hydrochloride	1001645-58-4	99.59%
T2412	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
T13795	Nicotinamide riboside	1341-23-7	99.58%
T13795	Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-in...
T6111	Selisistat	49843-98-3	99.54%
T6111	EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
T9999	Benzamide, N-(3-imidazo[2,1-b]thiazol-6-ylphenyl)-2-methoxy	667910-69-2	99.47%
T9999	Benzamide, N-(3-imidazo[2,1-b]thiazol-6-ylphenyl)-2-methoxy exhibits antidiabetic, anti-inflammatory and antitumor activities.
T1919	Tenovin-1	380315-80-0	99.44%
T1919	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T21679	4'-bromo-Resveratrol	1224713-90-9	99.4%
T21679	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)