T0934 |
Nicotinamide |
Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue an...
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T1558 |
ResveratrolHOT |
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc. |
T1818 |
Tenovin-6 |
Tenovin-6 is a p53 transcriptional activity agonist. |
T1873 |
Tenovin3 |
Tenovin-3 is a p53 activator. |
T1887 |
Inauhzin |
Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without...
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T2412 |
SRT1720 hydrochlorideHOT |
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM). |
T2879 |
Fisetin |
Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins. |
T3447 |
Thiomyristoyl |
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
T3953 |
Salermide |
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death. |
T4019 |
Cambinol |
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate...
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T4062 |
CAY10602 |
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific ...
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T4108 |
3-TYP |
3-TYP is a selective SIRT3 inhibitor. |
T6111 |
SelisistatHOT |
EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3. |
T6371 |
AGK2 |
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor. |
T6671 |
Sirtinol |
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM). |
T6678 |
Splitomicin |
Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. |
T6679 |
SRT2104 |
SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator. |
T6984 |
SirReal2 |
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
T4328 |
OSS_128167 |
OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
T5096 |
SRT 1720 |
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3. |
T5124 |
SRT 1720 dihydrochloride[925434-55-5(free base)] |
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM). |
T2S0300 |
Hydrocoumarin |
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wi...
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T5490 |
AK-7 |
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM. |
T5725 |
lithospermic acid B |
lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant...
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T6220 |
Nicotinamide riboside chloride |
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine d...
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T5618 |
AK-1 |
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in...
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T7679 |
UBCS039 |
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM) |
TN1071 |
Ophiopogonin D' |
Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10. |
TN1296 |
5-O-Feruloylquinic acid |
5-O-feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associate...
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TN2249 |
(+)-Syringaresinol |
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. |
T8346 |
SRT1460 |
SRT1460 is a SIRT1 activator. |
T13795 |
Nicotinamide riboside |
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-i...
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T16667 |
PROTAC Sirt2 Degrader-1 |
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a ...
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T15263 |
Selisistat R-enantiomer |
Selisistat R-enantiomer is much less active R-enantiomer of Selisistat (IC50 of > 100 μM for SIRT1). |
T12918 |
SIRT-IN-1 |
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively). |
T12919 |
SIRT-IN-2 |
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 4, 7 μM, respectively). |
T12920 |
Sirt2-IN-1 |
Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM). |
T13001 |
SRT3657 |
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect. |
T16932 |
SRT 2183 |
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM). |
T2750 |
Ginkgolide C |
Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body. |
T8480 |
Tenovin-6 Hydrochloride |
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pot...
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