Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.

Cat No.	product name
T3888	Scopolin	Scopolin formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis...
T4019	Cambinol	Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-,...
T39233	SIRT7 inhibitor 97491	SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
T4S1173	Agrimol B	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T6678	Splitomicin	Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
T6371	AGK2	AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.
T1919	Tenovin-1	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T1818	Tenovin-6	Tenovin-6 is a p53 transcriptional activity agonist.
T3953	Salermide	Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T6671	Sirtinol	Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T4328	OSS_128167	OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T2160	Suramin Sodium Salt	Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
T3S0175	Gardenia yellow	Kuchinashi yellow has anti atherosclerosis and hypolipidemic effects.
T0934	Nicotinamide	Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and...
TN1296	5-Feruloylquinic acid	5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
TN7093	N-Caffeoyltryptophan	N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 3...
T2750	Ginkgolide C	Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
T8480	Tenovin-6 Hydrochloride	Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
T16932	SRT 2183	SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T5S1133	Ganoderic acid D	1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervi...
T7679	UBCS039	UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T5725	Salvianolic acid B	lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant,...
T1558	Resveratrol	Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T2879	Fisetin	Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
T5096	SRT 1720	SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
T6220	Nicotinamide riboside chloride	Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine di...
T35347	Et-29	NRD167 是一种有效的选择性SIRT5抑制剂。
T7058	Selisistat S-enantiomer	EX-527 S-enantiomer is the S-enantiomer of EX-527, with an IC50 of 123 nM for SIRT1. EX-527 S-enantiomer is much more potent than EX-527 R-enantiomer.
T50080	MC2184	MC2184 is the inhibitor of human recombinant SIRT1.
T2S0300	Dihydrocoumarin	Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wit...
T1873	Tenovin-3	Tenovin-3 is a p53 activator.
T1887	Inauhzin	Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without ...
T21679	4'-bromo-Resveratrol	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
T2412	SRT1720 hydrochloride	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
TN1071	Ophiopogonin D'	Ophiopogonin D'可以以剂量依赖性方式激活 SIRT1。 Ophiopogonin D'也非竞争性地抑制 UGT1A6 和 UGT1A10。
TN2249	(+)-Syringaresinol	(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
T8346	SRT 1460	SRT1460 is a SIRT1 activator.
T9106	E1231	E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
T9320	YK-3-237	YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
T13001	SRT3657	SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
T12919	SIRT-IN-2	SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
T12918	SIRT-IN-1	SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
T12920	Sirt2-IN-1	Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
T6984	SirReal2	SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
T3447	Thiomyristoyl	Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T4062	CAY10602	CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
T4108	3-TYP	3-TYP is a selective SIRT3 inhibitor.
T6111	Selisistat	EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
T6679	SRT 2104	SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T5124	SRT 1720 dihydrochloride[925434-55-5(free base)]	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).