synthesize

Hydroxyamine hydrochloride(Hydroxylammonium chloride) is a selective and potent monoamine oxidase (MAO) inhibitor with inhibitory effects on platelet aggregation.Hydroxyamine hydrochloridee is an intermediate in organic synthesis and can be used to synthesize other active compounds.

2-chloro-5-(16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid can be used to synthesize a variety of organic compounds.

Isethionic acid sodium salt (Sodium isethionate) is an organosulfur compound containing a short chain alkane sulfonate linked to a hydroxyl group. Mammals are able to endogenously synthesize Isethionic acid sodium salt via taurine through a possible enzymatic deamination process. Isethionic acid sodium salt can be found in both human plasma and urine. Higher plasma levels of Isethionic acid sodium salt have been shown to be protective against type 2 diabetes.

2-Adamantanol (2-Hydroxyadamantane) was used to synthesize antiallergic drug Mizolastine.

Azido-PEG4-hydrazide is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Magnesium acetate tetrahydrate is the hydrated form of the anhydrous magnesium acetate salt.Magnesium acetate tetrahydrate is commonly used to synthesize other compounds, cocoa as an electrolyte supplement or as a reagent in molecular biology experiments.

Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].

Methyl 3-[2-[[(4R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]benzoate is a biochemical reagent that can be used to synthesize active compounds.

2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid is commonly used to synthesize compounds with anticancer and antitumor properties.

Propargyl-PEG12-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

L-Cyclohexylalanine (L-3-Cyclohexylalanine) is an amino acid analog that binds to the heavy enzyme thioester of the short peptide S synthase.L-Cyclohexylalanine can be used to synthesize anticoagulant decapeptides.

PC Biotin-PEG3-alkyne is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

Propargyl-PEG11-methane is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].

2-(Chloromethyl)imidazo[1,2-a]pyridine has potential anthelmintic activity and can be used to synthesize active compounds.

Diisopropyl xanthogen disulfide (NSC-1339) can be used to synthesize a proligand for metal complexes related to the molybdenum cofactor.

Gemtuzumab(CMA-676) is a monoclonal antibody directed against the CD33 antigen and consists of a recombinant humanized IgG4 antibody.Gemtuzumab can be used to synthesize Gemtuzumab ozogamicin, an antibody coupled compound (ADC) Gemtuzumab is used in the study of acute myeloid leukemia.

Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V (HY-130

(E)-3-(Naphth-1-yl)acrylic acid (3-(1-Naphthyl)acrylic acid) is a biochemical reagent that can be used to synthesize a variety of compounds and participate in many reactions in the body.

p-Valerylphenol (NSC-49186) can be used to synthesize acylphenoxyacetic acid compounds.

(R)-PF-04822163 is a biochemical reagent that can be used to synthesize other compounds.

DBCO-PEG3-NHS ester is a degradable ADC linker that can be used to synthesize antibody-coupled active molecules.

Corticotropin-releasing factor (human) acetate stimulates to synthesize and secret adrenocorticotropin in the anterior pituitary.

1-[(5-chlorothiophen-2-yl)sulfonyl]pyrrolidine-2-carboxylic acid has been used as a starting material for the synthesis of drugs, polymers, etc., and has also been used to synthesize bioactive compounds such as peptides, peptoids, and Other small molecules.

Azido-PEG4-azide is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

3-Bromo-6-chloro-2-pyridinecarboxylic acid is a biochemical reagent that can be used to synthesize other compounds.

Benzopinacole is an anti-amoeba drug that can be used as an intermediate to synthesize a variety of compounds.

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitor that inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride contains the target protein PD-1/PD-L1 ligand and PROTAC linker.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used to synthesize PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used to synthesize PROTAC PD-1/PD-L1 degrader-1. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride has anticancer activity. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used as a diluent for the preparation of tablets for direct compression.

Paclitaxel-SMCC is a paclitaxel derivative with a SMCC linker. (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Paclitaxel-SMCC can be used to synthesize Paclitaxel bioconjugates with enzymes, antobodies, antigens and other biopolymers. Pa

T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription (IVT) of mRNA. This polymerase requires Mg 2+ and selects only DNA templates that contain the T7 promoter sequence, whether single-stranded or double-stranded. It employs NTPs to synthesize RNA that is complementary to the single-stranded DNA following the promoter [1] [2].

Folcysteine is a cysteine derivative with potential antitumor agent. It's a vitamin that used to synthesize DNA, conduct DNA repair and methylate DNA. It also acts as a cofactor in biological reactions involving folate.

Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.

Azido-C6-OH is a cleavable ADC linker used to synthesize antibody-drug conjugates (ADCs).

14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.

C8 PEG-Ceramide, a lipid product, possesses the capability to synthesize lipid bilayer carriers, making it applicable for drug delivery [1] [2].

Lupartumab (BAY 1112623) is an anti-LYPD3 (C4.4A) monoclonal antibody that can be used to synthesize antibody-active molecular couplers that can be used to study LYPD3-associated tumor diseases.

3-Chlorophenylboronic acid, a phenylboronic acid derivative, is an important intermediate in the synthesis of prolyl hydroxylase inhibitors, and can be used to synthesize a variety of compounds.The IC50 of 3-Chlorophenylboronic acid for lysophospholipase LYPLA2 was 0.418 µM.

DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065.

3-Hydroxyphthalic anhydride is used to synthesize 3-hydroxyphthalic anhydride modified human serum albumin.

2,4-Dihydroxypyrimidine-5-carboxylic acid (Isoorotic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. 2,4-Dihydroxypyrimidine-5-carboxylic acid has been used to synthesize N1-alkylated uracil derivatives.

Enapotamab is an AXL/UFO-related antibody that can be used to synthesize antibody-drug couplings (Enapotamab Vedotin).

Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate.

9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME (1 g/animal) enhances the antiviral IgA and IgG antibody responses induced by a nasal influenza hemagglutinin (HA) vaccine by 5.2- and 2-fold, respectively, in mice.4 1.Hamberg, M., and Hamberg, G.Peroxygenase-catalyzed fatty acid epoxidation in cereal seeds: Sequential oxidation of linoleic acid into 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acidPlant Physiol.110(3)807-815(1996) 2.Hong, S.S., and Oh, J.S.Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat branJ. Korean Soc. Appl. Biol. Chem.5569-74(2012) 3.Kim, C.S., Kwon, O.W., Kim, S.Y., et al.Five new oxylipins from Chaenomeles sinensisLipids49(11)1151-1159(2014) 4.Shirahata, T., Sunazuka, T., Yoshida, K., et al.Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acidsTetrahedron62(40)9483-9496(2006) 5.Fuchs, D., Tang, X., Johnsson, A.-K., et al.Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent processBiochim. Biophys. Acta Mol. Cell Biol. Lipids1865(4)158611(2020)

4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine ((4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone) is a raw material for biosynthesis and can be used to synthesize a wide variety of compounds.

Tusamitamab is an IgG1 monoclonal antibody targeting CEACAM5 and is the naked antibody to Tusamitamab ravtansine.Tusamitamab can be used to synthesize the antibody-activator coupling Tusamitamab ravtansine.

Bz-(Me)Tz-NHS is a lipid compound containing a methyltetrazine moiety.Bz-(Me)Tz-NHS is selective and can be used to synthesize a wide range of active molecules in biomedical research.

Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker. Propargyl-PEG3-acid is also a PEG-based PROTAC linker used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1].

Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjugates (ADCs). Rovalpituzumab has anticancer activity and is used to treat small cell lung cancer (SCLC).

Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4 antibody targeting CD22. Inotuzumab is a naked antibody to Inotuzumab ozogamicin and can be used to synthesize antibody-active molecule conjugators (Inotuzumab ozogamicin). Inotuzumab can be used to study acute lymphoblastic leukemia and non-Hodgkin's lymphoma.