ATM/ATR

ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, NBS1 and H2AX are tumor suppressors. ATR is a serine/threonine kinase and belongs to the phosphoinositide 3- kinase related protein kinases (PIKKs), particularly to ATM (ataxia telangiectasia mutated) subfamily. It functions to maintain genome integrity by stabilizing replication forks and by regulating cell cycle progression and DNA repair.

Cat. No.	Product name	CAS No.	Purity
T16773	Ro 90-7501	293762-45-5	98%
T16773	Ro 90-7501 is an amyloid β42 fibril assembly inhibitor (EC50: 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. Ro 90-7501 also inhibits PP5 in a TP...
T10407	Gartisertib	1613191-99-3	98%
T10407	ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-dri...
T10396	ATM Inhibitor-1	2135639-94-8	98%
T10396	ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM...
T15673	KU 59403	845932-30-1	98%
T15673	KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
TN1673	Garcinone C	76996-27-5	98%
TN1673	Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcin...
T1958	AZ20	1233339-22-4	98.02%
T1958	AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
T2925	Schisandrin B	61281-37-6	99.02%
T2925	Schisandrin B has an antioxidant effect on rodent liver and heart.
T6770	AZD0156	1821428-35-6	99.13%
T6770	AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
T2669	Berzosertib	1232416-25-9	99.19%
T2669	VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid ...
T5175	Azd1390	2089288-03-7	99.38%
T5175	AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enz...
T6100	Torin 2	1223001-51-1	99.47%
T6100	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
T2084	ETP-46464	1345675-02-6	99.56%
T2084	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T1821	CGK733	905973-89-9	99.7%
T1821	CGK 733 is a potent and selective inhibitor of ATM/ATR.
T7318	Elimusertib	1876467-74-1	99.75%
T7318	BAY 1895344 is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.BAY 1895344 shows potent anti-tumor efficacy in monotherapy and...
T6283	Wortmannin	19545-26-7	99.76%
T6283	Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
T2616	PIK-93	593960-11-3	99.83%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T6261	CP-466722	1080622-86-1	99.85%
T6261	CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
T6612	NU6027	220036-08-8	99.85%
T6612	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
T2235	Dactolisib	915019-65-7	99.85%
T2235	Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
T10468	Elimusertib hydrochloride(1876467-74-1 free base)	T10468	99.86%
T10468	Elimusertib hydrochloride is a effective, orally available and selective ATR inhibitor with anti-tumor activity.