T16773 |
Ro 90-7501
|
293762-45-5
|
98%
|
|
Ro 90-7501 is an amyloid β42 fibril assembly inhibitor (EC50: 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. Ro 90-7501 also inhibits PP5 in a TP...
|
T10407 |
Gartisertib
|
1613191-99-3
|
98%
|
|
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-dri...
|
T10396 |
ATM Inhibitor-1
|
2135639-94-8
|
98%
|
|
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM...
|
T15673 |
KU 59403
|
845932-30-1
|
98%
|
|
KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
|
TN1673 |
Garcinone C
|
76996-27-5
|
98%
|
|
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcin...
|
T1958 |
AZ20
|
1233339-22-4
|
98.02%
|
|
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
|
T2925 |
Schisandrin B
|
61281-37-6
|
99.02%
|
|
Schisandrin B has an antioxidant effect on rodent liver and heart.
|
T6770 |
AZD0156
|
1821428-35-6
|
99.13%
|
|
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
|
T2669 |
Berzosertib
|
1232416-25-9
|
99.19%
|
|
VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid ...
|
T5175 |
Azd1390
|
2089288-03-7
|
99.38%
|
|
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enz...
|
T6100 |
Torin 2
|
1223001-51-1
|
99.47%
|
|
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
|
T2084 |
ETP-46464
|
1345675-02-6
|
99.56%
|
|
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
|
T1821 |
CGK733
|
905973-89-9
|
99.7%
|
|
CGK 733 is a potent and selective inhibitor of ATM/ATR.
|
T7318 |
Elimusertib
|
1876467-74-1
|
99.75%
|
|
BAY 1895344 is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.BAY 1895344 shows potent anti-tumor efficacy in monotherapy and...
|
T6283 |
Wortmannin
|
19545-26-7
|
99.76%
|
|
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
|
T2616 |
PIK-93
|
593960-11-3
|
99.83%
|
|
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
|
T6261 |
CP-466722
|
1080622-86-1
|
99.85%
|
|
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
|
T6612 |
NU6027
|
220036-08-8
|
99.85%
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
|
T2235 |
Dactolisib
|
915019-65-7
|
99.85%
|
|
Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
|
T10468 |
Elimusertib hydrochloride(1876467-74-1 free base)
|
T10468
|
99.86%
|
|
Elimusertib hydrochloride is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
|