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Fatty Acid Synthase

Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1365 Albaspidin AP 59092-91-0 98%
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promisi...
T11266L FAS-IN-1 Tosylate T11266L 98%
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
T27307L Fasnall HCl 98%
Fasnall HCl is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall HCl also shows potent anti-tumor activity in the MMTV-Neu model ...
TN2083 Pinostrobin chalcone 18956-15-5 98%
Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through th...
TN4094 Gallocatechin gallate 5127-64-0 98%
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
T4S1421 Praeruptorin B 73069-28-0 98%
Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
TN1751 Hydroxycitric acid 6205-14-7 98%
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
T3S1701 Dihydrocurcumin 76474-56-1 98%
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and pr...
T21831 UCM05 1094451-90-7 98%
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase ( FASN ) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resist...
TN2535 1-Hydroxy-2-oxopomolic acid 217466-37-0 98%
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
T14570 BI 99179 1291779-76-4 98%
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cent...
T11267 FASN-IN-1 1808260-84-5 98%
FASN-IN-1 is a fatty acid synthase (FASN) inhibitor .
T36841 IPI-9119 1346564-56-4 98%
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
T27307 Fasnall 929978-58-5 98%
Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
T21724L Fas C-Terminal Tripeptide Acetate T21724L
Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
T14298 Rimiducid 195514-63-7
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
T7947 FT113 1630808-89-7 97.68%
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
TN1803 Isoscoparin 20013-23-4 97.95%
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
T5S0246 Pseudoprotodioscin 102115-79-7 98%
1. Pseudoprotodioscin has moderate cytotoxicity.
TJS0387 Desoxyrhaponticin 30197-14-9 98%
1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this com...
Albaspidin AP
TN1365
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promisi...
FAS-IN-1 Tosylate
T11266L
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
Fasnall HCl
T27307L
Fasnall HCl is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall HCl also shows potent anti-tumor activity in the MMTV-Neu model ...
Pinostrobin chalcone
TN2083
Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through th...
Gallocatechin gallate
TN4094
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Praeruptorin B
T4S1421
Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
Hydroxycitric acid
TN1751
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
Dihydrocurcumin
T3S1701
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and pr...
UCM05
T21831
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase ( FASN ) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resist...
1-Hydroxy-2-oxopomolic acid
TN2535
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
BI 99179
T14570
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and cent...
FASN-IN-1
T11267
FASN-IN-1 is a fatty acid synthase (FASN) inhibitor .
IPI-9119
T36841
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
Fasnall
T27307
Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
Fas C-Terminal Tripeptide Acetate
T21724L
Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
Rimiducid
T14298
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
FT113
T7947
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
Isoscoparin
TN1803
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
Pseudoprotodioscin
T5S0246
1. Pseudoprotodioscin has moderate cytotoxicity.
Desoxyrhaponticin
TJS0387
1. Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this com...
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