Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.

Cat No.	product name
T16479	PF-04937319	PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4 μM)。 PF-04937319 保持降糖功效，同时降低许多其他 GKA 观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。
T21344	1-Deoxynojirimycin hydrochloride	Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of po...
T19500	Palmitelaidic Acid	Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
T3235	Rebaudioside A	Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.
T2455	PFK-015	PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
T6S2122	Ginkgolic Acid (C13:0)	1.Ginkgolic acid C13: 0exhibits the highest α-glucosidase inhibitory activity.
T3S2072	3-Butylidenephthalide	1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucos...
T7858	Ceftezole sodium	Ceftezole sodium is a broad-spectrum cephalosporin antibiotic active gram-negative and gram-positive bacteria except for Proteus vulgaris, Pseudomonas aeruginosa...
T11741	KAN0438757	KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
T0714	Oxfendazole	Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
TN2130	Manghaslin	Manghaslin has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also sh...
T3675	1-Deoxynojirimycin	1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
T3105	PFK-158	PFK-158 is an effective and specific inhibitor PFKFB3.
TN1451	Brevifolincarboxylic acid	Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
T22223	3PO	3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines ...
T6S1371	Isovitexin	1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
T3386	Kaempferitrin	Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
T3S1612	Kuwanon G	1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for ...
T26712	AZD-1656	AZD-1656, a glucokinase (GK) activator, is used potentially for the treatment of type 2 diabetes and obesity.
T001-00000001	ML251	ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=...
TL0008	Gigantol	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-cat...
T8202	Kaempferol 3-O-gentiobioside	Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a ...
T7028	Licochalcone C	Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, an...
T8319	Butyl isobutyl phthalate	Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
T8260	4',5-Dihydroxyflavone	4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
T8986	ML198	ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
T12142	N-Caffeoyl O-methyltyramine	N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
T12056	MK-0941 free base	MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
T11749	KDM4-IN-2	KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T13130	Terphenyllin	Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
T10751	Cefetrizole	Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
TN4174	Guajadial	Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Recep...
TN3745	Cyclomusalenone	Cyclomusalenone is a potent α-glucosidase inhibitor.
TN3487	Balanophonin	Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial act...
TN4793	Pinoresinol diacetate	Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
TN5094	Tangshenoside I	Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
TN5090	Tachioside	Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows...
TN5192	Tuberosin	Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
TN6784	Ethyl rosmarinate	Methyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).
TQ0055	AMG-3969	AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
TQ0308	Castanospermine	Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
TQ0300	Conduritol B epoxide	Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
T6S0535	Pinoresinol diglucoside	1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
T3871	Daucosterol	Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprote...
T3104	Globalagliatin	LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T3260	(E)-3PO	(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
T3312	AM-2394	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 incre...
T4280	Gcase activator 1	LTI-291 is a glucocerebrosidase (Gcase) activator.
T4049	Genz-123346 free base	Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
T5489	Tryptophan, N-indol-3-ylacetyl- (6CI)	Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may...