Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.

Cat. No.	Product name	CAS No.	Purity
T16480	PF-04991532	1215197-37-7	98%
T16480	PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
TN4174	Guajadial	959860-49-2	98%
TN4174	Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Recep...
T11749	KDM4-IN-2	2369607-62-3	98%
T11749	KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T14212	AMG-1694	1361217-07-3	98%
T14212	AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, i...
TN3745	Cyclomusalenone	30452-60-9	98%
TN3745	Cyclomusalenone is a potent α-glucosidase inhibitor.
TN5094	Tangshenoside I	117278-74-7	98%
TN5094	Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
T10751	Cefetrizole	65307-12-2	98%
T10751	Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
TN3487	Balanophonin	118916-57-7	98%
TN3487	Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial act...
TN4793	Pinoresinol diacetate	32971-25-8	98%
TN4793	Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
TN5090	Tachioside	109194-60-7	98%
TN5090	Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows...
TN5192	Tuberosin	41347-45-9	98%
TN5192	Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
T23552	YZ9	6093-71-6	98%
T23552	PFKFB3 inhibitor
T3105	PFK-158	1462249-75-7	98%
T3105	PFK-158 is an effective and specific inhibitor PFKFB3.
T3104	Globalagliatin	1234703-40-2	98%
T3104	LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T8986	ML198	1380716-06-2	98%
T8986	ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
T8990	ML266	1462267-08-8	98%
T8990	ML266 is glucocerebrosidase (GCase) molecule chaperone, IC50 = 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the ...
T12056	MK-0941 free base	752240-01-0	98%
T12056	MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
T4049	Genz-123346 free base	491833-30-8	98%
T4049	Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
T60048	WAY-640509	851185-20-1	98%
T60048	WAY-640509 is a glucocerebrosidase inhibitor.
T16479	PF-04937319	1245603-92-2	98%
T16479	PF-04937319 is an activator of glucokinase (EC50 =154.4 μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed ...