Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.

Cat No.	product name
T0247	Acarbose	Acarbose is an inhibitor of α-Glucosidases with antihyperglycemic activity.
T0714	Oxfendazole	Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
T2455	PFK-015	PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
T3104	LY2608204	LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T3105	PFK-158	PFK-158 is an effective and specific inhibitor PFKFB3.
T3260	3PO	3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor.
T3312	AM-2394	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 incr...
T3386	Kaempferitrin	Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects agains...
T3871	Sitogluside	Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprot...
T4049	Genz-123346 free base	Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
T6723	Voglibose	Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and vario...
T4280	LTI-291	LTI-291 is a glucocerebrosidase (Gcase) activator.
T3S1612	kuwanon G	1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment fo...
T3S2072	n-Butylidenephthalide	1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-g...
T6S0535	Pinoresinol diglucoside	1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
T6S1371	Isovitexin	1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
TL0008	Gigantol	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β...
T5489	Tryptophan, N-indol-3-ylacetyl- (6CI)	Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It ma...
TWS0787	Oroxin A	Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
T5690	4',7-DIMETHOXY-5-HYDROXYFLAVONE	4',7-DIMETHOXY-5-HYDROXYFLAVONE can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pr...
TQ0055	AMG-3969	AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
TQ0300	Conduritol B epoxide	Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
TQ0308	Castanospermine	Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
T7028	LICOCHALCONEC	Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, a...
T3235	Rebaudioside A	Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.
T8260	4',5-Dihydroxyflavone	4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
T8202	Kaempferol 3-gentiobioside	Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays ...
T8319	Butyl isobutyl phthalate	Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
TN2130	Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside	Quercetin 3-O-rutinoside-(12)-O-rhamnoside shows α±-glucosidase inhibitory activity, it has anti-diabetic potential.
T12056	MK-0941 free base	MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of t...
T12142	N-Caffeoyl O-methyltyramine	N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
T14212	AMG-1694	AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM...
T14365	AZ PFKFB3 26	AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively[1]. AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kin...
T15159	Dorzagliatin	Dorzagliatin is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
T13130	Terphenyllin	Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
T10751	Cefetrizole	Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
T11749	KDM4-IN-2	KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T16480	PF-04991532	PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
TN3487	Balanophonin	Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial ...
TN3745	Cyclomusalenone	Cyclomusalenone is a potent α-glucosidase inhibitor.
TN4174	Guajadial	Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Rec...
TN4793	Pinoresinol diacetate	Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
TN5090	Tachioside	Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, sho...
TN5094	Tangshenoside I	Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as ...
TN5192	Tuberosin	Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manne...