T0247 |
Acarbose |
Acarbose is an inhibitor of α-Glucosidases with antihyperglycemic activity. |
T0714 |
Oxfendazole |
Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms. |
T2455 |
PFK-015 |
PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM). |
T3104 |
LY2608204 |
LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2. |
T3105 |
PFK-158 |
PFK-158 is an effective and specific inhibitor PFKFB3. |
T3260 |
3PO |
3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. |
T3312 |
AM-2394 |
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 incr...
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T3386 |
Kaempferitrin |
Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects agains...
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T3871 |
Sitogluside |
Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprot...
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T4049 |
Genz-123346 free base |
Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1. |
T6723 |
Voglibose |
Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and vario...
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T4280 |
LTI-291 |
LTI-291 is a glucocerebrosidase (Gcase) activator. |
T3S1612 |
kuwanon G |
1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment fo...
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T3S2072 |
n-Butylidenephthalide |
1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-g...
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T6S0535 |
Pinoresinol diglucoside |
1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound. |
T6S1371 |
Isovitexin |
1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo. |
T6S2122 |
Ginkgolic acid C13:0 |
1.Ginkgolic acid C13: exhibits the highest α-glucosidase inhibitory activity. |
TL0008 |
Gigantol |
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β...
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T5489 |
Tryptophan, N-indol-3-ylacetyl- (6CI) |
Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It ma...
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TWS0787 |
Oroxin A |
Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity again...
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T5690 |
4',7-DIMETHOXY-5-HYDROXYFLAVONE |
4',7-DIMETHOXY-5-HYDROXYFLAVONE can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pr...
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TQ0055 |
AMG-3969 |
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM). |
TQ0300 |
Conduritol B epoxide |
Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase). |
TQ0308 |
Castanospermine |
Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l. |
T7028 |
LICOCHALCONEC |
Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, a...
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T3235 |
Rebaudioside A |
Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor. |
T8260 |
4',5-Dihydroxyflavone |
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM). |
T8202 |
Kaempferol 3-gentiobioside |
Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays ...
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T8319 |
Butyl isobutyl phthalate |
Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect |
TN2130 |
Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside |
Quercetin 3-O-rutinoside-(12)-O-rhamnoside shows α±-glucosidase inhibitory activity, it has anti-diabetic potential. |
T12056 |
MK-0941 free base |
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of t...
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T12142 |
N-Caffeoyl O-methyltyramine |
N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM. |
T14212 |
AMG-1694 |
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM...
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T14365 |
AZ PFKFB3 26 |
AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively[1]. AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kin...
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T15159 |
Dorzagliatin |
Dorzagliatin is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes. |
T13130 |
Terphenyllin |
Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus. |
T10751 |
Cefetrizole |
Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM). |
T11749 |
KDM4-IN-2 |
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively. |
T16480 |
PF-04991532 |
PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively. |
TN3487 |
Balanophonin |
Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial ...
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TN3745 |
Cyclomusalenone |
Cyclomusalenone is a potent α-glucosidase inhibitor. |
TN4174 |
Guajadial |
Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Rec...
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TN4793 |
Pinoresinol diacetate |
Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent. |
TN5090 |
Tachioside |
Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, sho...
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TN5094 |
Tangshenoside I |
Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as ...
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TN5192 |
Tuberosin |
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manne...
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