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Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.
Cat No. product name
T16479 PF-04937319 PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4  μM)。 PF-04937319 保持降糖功效,同时降低许多其他 GKA 观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。
T21344 1-Deoxynojirimycin hydrochloride Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of po...
T19500 Palmitelaidic Acid Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
T3235 Rebaudioside A Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.
T2455 PFK-015 PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
T6S2122 Ginkgolic Acid (C13:0) 1.Ginkgolic acid C13: 0exhibits the highest α-glucosidase inhibitory activity.
T3S2072 3-Butylidenephthalide 1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucos...
T7858 Ceftezole sodium Ceftezole sodium is a broad-spectrum cephalosporin antibiotic active gram-negative and gram-positive bacteria except for Proteus vulgaris, Pseudomonas aeruginosa...
T11741 KAN0438757 KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
TN2130 Manghaslin Manghaslin has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also sh...
T3675 1-Deoxynojirimycin 1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
T3105 PFK-158 PFK-158 is an effective and specific inhibitor PFKFB3.
TN1451 Brevifolincarboxylic acid Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
T22223 3PO 3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines ...
T6S1371 Isovitexin 1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
T3386 Kaempferitrin Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
T3S1612 Kuwanon G 1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for ...
T26712 AZD-1656 AZD-1656, a glucokinase (GK) activator, is used potentially for the treatment of type 2 diabetes and obesity.
T001-00000001 ML251 ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=...
TL0008 Gigantol Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-cat...
T8202 Kaempferol 3-O-gentiobioside Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a ...
T7028 Licochalcone C Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, an...
T8319 Butyl isobutyl phthalate Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
T8260 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
T8986 ML198 ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
T12142 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
T12056 MK-0941 free base MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
T11749 KDM4-IN-2 KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T13130 Terphenyllin Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
T10751 Cefetrizole Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
TN4174 Guajadial Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Recep...
TN3745 Cyclomusalenone Cyclomusalenone is a potent α-glucosidase inhibitor.
TN3487 Balanophonin Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial act...
TN4793 Pinoresinol diacetate Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
TN5094 Tangshenoside I Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
TN5090 Tachioside Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows...
TN5192 Tuberosin Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
TN6784 Ethyl rosmarinate Methyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).
TQ0055 AMG-3969 AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
TQ0308 Castanospermine Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
TQ0300 Conduritol B epoxide Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
T6S0535 Pinoresinol diglucoside 1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
T3871 Daucosterol Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprote...
T3104 Globalagliatin LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T3260 (E)-3PO (E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
T3312 AM-2394 AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 incre...
T4280 Gcase activator 1 LTI-291 is a glucocerebrosidase (Gcase) activator.
T4049 Genz-123346 free base Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
T5489 Tryptophan, N-indol-3-ylacetyl- (6CI) Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may...
PF-04937319
T16479
1-Deoxynojirimycin hydrochloride
T21344
Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of po...
Palmitelaidic Acid
T19500
Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
Rebaudioside A
T3235
Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.
PFK-015
T2455
PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
Ginkgolic Acid (C13:0)
T6S2122
1.Ginkgolic acid C13: 0exhibits the highest α-glucosidase inhibitory activity.
3-Butylidenephthalide
T3S2072
1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-gluc...
Ceftezole sodium
T7858
Ceftezole sodium is a broad-spectrum cephalosporin antibiotic active gram-negative and gram-positive bacteria except for Proteus vulgaris, Pseudomonas aeruginosa...
KAN0438757
T11741
KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
Oxfendazole
T0714
Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
Manghaslin
TN2130
Manghaslin has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also s...
1-Deoxynojirimycin
T3675
1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
PFK-158
T3105
PFK-158 is an effective and specific inhibitor PFKFB3.
Brevifolincarboxylic acid
TN1451
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
3PO
T22223
3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines...
Isovitexin
T6S1371
1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
Kaempferitrin
T3386
Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
kuwanon G
T3S1612
1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for...
AZD-1656
T26712
AZD-1656, a glucokinase (GK) activator, is used potentially for the treatment of type 2 diabetes and obesity.
ML251
T001-00000001
ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50...
Gigantol
TL0008
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-...
Kaempferol 3-O-gentiobioside
T8202
Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a...
Licochalcone C
T7028
Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, an...
Butyl isobutyl phthalate
T8319
Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
4',5-Dihydroxyflavone
T8260
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
ML198
T8986
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
N-Caffeoyl O-methyltyramine
T12142
N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
MK-0941 free base
T12056
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
KDM4-IN-2
T11749
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
Terphenyllin
T13130
Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
Cefetrizole
T10751
Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
Guajadial
TN4174
Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Rece...
Cyclomusalenone
TN3745
Cyclomusalenone is a potent α-glucosidase inhibitor.
Balanophonin
TN3487
Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial a...
Pinoresinol diacetate
TN4793
Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
Tangshenoside I
TN5094
Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
Tachioside
TN5090
Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, show...
Tuberosin
TN5192
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner...
ethyl rosmarinate
TN6784
Methyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).
AMG-3969
TQ0055
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
Castanospermine
TQ0308
Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
Conduritol B epoxide
TQ0300
Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
Pinoresinol diglucoside
T6S0535
1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
Daucosterol
T3871
Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprote...
Globalagliatin
T3104
LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
(E)-3PO
T3260
(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
AM-2394
T3312
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 incre...
Gcase activator 1
T4280
LTI-291 is a glucocerebrosidase (Gcase) activator.
Genz-123346 free base
T4049
Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
Tryptophan, N-indol-3-ylacetyl- (6CI)
T5489
Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may...
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