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Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands.
Cat No. product name
T9605 Sangivamycin Sangivamycin 是蛋白激酶 C (PKC) 的有效抑制剂 (Ki = 10 μM)。 Sangivamycin 对多种人类癌症细胞具有抗增殖活性。
T0688 Ganciclovir Ganciclovir is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications fro...
T36944 Ara-G Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, wh...
T40192 DGTP dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
T0251 Gemcitabine Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
T6794 5-BrdU Bromodeoxyuridine (BrdU), a nucleoside analog, are used in the detection of proliferating cells and competes with thymidine for incorporation into DNA.
T4061 LY2334737 LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
T1120 Dacarbazine Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
T1428 Trifluridine Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, r...
T0853 Adenosine Adenosine is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
T36866 3-Deazauridine 3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate sy...
T9726 2’-OMe-Guanosine 2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.
T1591L Cytidine Cytidine is a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond. Cytidine is a precursor for uridine. Both cytidine and...
T22337 Ganciclovir sodium Ganciclovir Sodium, the sodium salt form of ganciclovir, is a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomega...
T0543 7-Methylxanthine 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi.
T7514 N2-Methylguanosine N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's
T3658 Trifluridine/tipiracil hydrochloride mixture TAS-102 is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
T5539 GS-443902 GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T7520 Deoxycytidine triphosphate Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-tim...
T38237 2′-O-Methylcytidine 2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replic...
T2201 6-Mercaptopurine hydrate 6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in...
T0532 5,6-Dihydro-5-methyluracil Dihydrothymine is an intermediate breakdown product of thymine.
T20102 8-Azahypoxanthine 8-Azahypoxanthine is an antimalarial. It inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase.
T0964 Floxuridine Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T6632 Raltitrexed Raltitrexed(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
T0297 Clofarabine Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65...
T0984 5-Fluorouracil Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.
T9727 2'-Fluoro-2'-Deoxyadenosine 2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-De...
T1307 Carmofur Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
T38958 DMT-2′Fluoro-dU Phosphoramidite DMT-2′Fluoro-dU Phosphoramidite can be used to modify nucleosides.
T7518 Deoxycytidine triphosphate trisodium salt 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI Oxidation contributes to antibiotic lethality in stationary-phase mycobacteria.
T6603 Nelarabine Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
T1272 Cytarabine Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterical...
T1378 Tegafur Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the ...
T15378 Gemcitabine elaidate Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential ...
T13621 CNDAC hydrochloride CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
T1508 Decitabine Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
T8354 Triazavirin Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.
T6069 Gemcitabine hydrochloride Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively).
T0010 6-Mercaptopurine Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabo...
T15235 Enocitabine Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus...
T1404 Stavudine Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
T2218 8-Azaguanine 8-Azaguanine is a purine analogue with potential antineoplastic activity.
T1038 Fludarabine Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
T1506 Vidarabine Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA ...
T0746 Orotic acid Orotic acid is an intermediate product in pyrimidine metabolism.
T36971 5-Ethynyluridine 5-Ethynyluridine is a clickable form of uridine.1It is incorporated into cellular RNA, but not DNA, and has been used to detect transcriptionin vitroandin vivo. ...
T6501 Fludarabine Phosphate Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activ...
T8648 6-AZATHYMINE 6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase. 6-Azauracil acted as a competitive inhibitor with respect to beta-alanine,...
T13659 DMTr-LNA-5MeU-3-CED-phosphoramidite DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
Sangivamycin
T9605
Sangivamycin 是蛋白激酶 C (PKC) 的有效抑制剂 (Ki = 10 μM)。 Sangivamycin 对多种人类癌症细胞具有抗增殖活性。
Ganciclovir
T0688
Ganciclovir is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications fro...
Ara-G
T36944
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, wh...
dGTP
T40192
dGTP is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
Gemcitabine
T0251
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy.
5-BrdU
T6794
Bromodeoxyuridine (BrdU), a nucleoside analog, are used in the detection of proliferating cells and competes with thymidine for incorporation into DNA.
LY2334737
T4061
LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
Dacarbazine
T1120
Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.
Trifluridine
T1428
Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, r...
Adenosine
T0853
Adenosine is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
3-Deazauridine
T36866
3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate sy...
2’-OMe-Guanosine
T9726
2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.
Cytidine
T1591L
Cytidine is a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond. Cytidine is a precursor for uridine. Both cytidine and...
Ganciclovir sodium
T22337
Ganciclovir Sodium, the sodium salt form of ganciclovir, is a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomega...
7-Methylxanthine
T0543
7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi.
N2-Methylguanosine
T7514
N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's
Trifluridine/tipiracil hydrochloride mixture
T3658
TAS-102 is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
Deoxycytidine triphosphate
T7520
Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-tim...
2′-O-Methylcytidine
T38237
2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV repli...
6-Mercaptopurine hydrate
T2201
6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in...
5,6-Dihydro-5-methyluracil
T0532
Dihydrothymine is an intermediate breakdown product of thymine.
8-Azahypoxanthine
T20102
8-Azahypoxanthine is an antimalarial. It inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Floxuridine
T0964
Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
Raltitrexed
T6632
Raltitrexed(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
Clofarabine
T0297
Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65...
5-Fluorouracil
T0984
Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.
2'-Fluoro-2'-Deoxyadenosine
T9727
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-De...
Carmofur
T1307
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
DMT-2′Fluoro-dU Phosphoramidite
T38958
DMT-2′Fluoro-dU Phosphoramidite can be used to modify nucleosides.
Deoxycytidine triphosphate trisodium salt
T7518
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI Oxidation contributes to antibiotic lethality in stationary-phase mycobacteria.
Nelarabine
T6603
Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
Cytarabine
T1272
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterical...
Tegafur
T1378
Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the ...
Gemcitabine elaidate
T15378
Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential ...
CNDAC hydrochloride
T13621
CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
Decitabine
T1508
Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
Triazavirin
T8354
Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.
Gemcitabine hydrochloride
T6069
Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively).
6-Mercaptopurine
T0010
Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabo...
Enocitabine
T15235
Enocitabine, a nucleoside analog, is a potent DNA replication inhibitor and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus...
Stavudine
T1404
Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
8-Azaguanine
T2218
8-Azaguanine is a purine analogue with potential antineoplastic activity.
Fludarabine
T1038
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
Vidarabine
T1506
Vidarabine is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA ...
Orotic acid
T0746
Orotic acid is an intermediate product in pyrimidine metabolism.
5-Ethynyluridine
T36971
5-Ethynyluridine is a clickable form of uridine.1It is incorporated into cellular RNA, but not DNA, and has been used to detect transcriptionin vitroandin vivo. ...
Fludarabine Phosphate
T6501
Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activ...
6-AZATHYMINE
T8648
6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase. 6-Azauracil acted as a competitive inhibitor with respect to beta-alanine,...
DMTr-LNA-5MeU-3-CED-phosphoramidite
T13659
DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
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