STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.

Cat. No.	Product name	CAS No.	Purity
T9554	SN-008	2249106-01-0	98%
T9554	SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
T10252L2	ADU-S100 ammonium salt	1638750-96-5	98%
T10252L2	ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immuni...
T5516	DiABZI STING agonist-1 trihydrochloride	2138299-34-8	98%
T5516	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
T9853	STING activator Compound 53	2259624-71-8	98%
T9853	STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised ...
T7329	C-178	329198-87-0	98%
T7329	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells...
T9029	STING-IN-3	2244881-69-2	98.15%
T9029	C-171 is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation...
T6919	Omaveloxolone	1474034-05-3	98.7%
T6919	Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T8328	STING agonist-1	702662-50-8	98.76%
T8328	STING agonist-1 is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
T9028	STING-IN-2	346691-38-1	98.76%
T9028	C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflam...
T8798	MSA-2	129425-81-6	98.88%
T8798	MSA-2 is a potent and orally available non-nucleotide STING agonist.
T13613	ChX710	2438721-44-7	99.51%
T13613	ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequenc...
T9204	N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide	727699-84-5	99.51%
T9204	N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide was reported as a STING inhbiitor, which inhibited the activation of the STING signal pat...
T5674	H-151	941987-60-6	99.52%
T5674	H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
T60000	2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)-	702662-64-4	99.61%
T60000	2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)- is a STING modulator with antibacterial and antiviral...
T7081	CCCP	555-60-2	99.64%
T7081	CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T6273	Vadimezan	117570-53-3	99.8%
T6273	Vadimezan is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-...
T5317	Cridanimod	38609-97-1	99.96%
T5317	Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/...
T5154	C-176	314054-00-7	99.97%
T5154	C-176 is a strong, covalent mouse STING inhibitor
T8655	SR-717	2375421-09-1	99.98%
T8655	SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor acti...
T13015	STING agonist-4	2138300-40-8	98%
T13015	STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).