T63313 |
Unecritinib
|
1418026-92-2
|
98%
|
|
Unecritinib (TQ-B3101) is a potent EGFR tyrosine kinase inhibitor. Unecritinib shows anticancer activity. Unecritinib inhibits ALK, ROS1, and MET. Unecritinib ha...
|
T8409 |
SYN1143
|
913376-84-8
|
98%
|
|
AMG-1 is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and...
|
TN4474 |
Macrocarpal B
|
142698-60-0
|
98%
|
|
The intestinal absorption of M-A, Macrocarpal B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.
|
T12418 |
PF-04217903 phenolsulfonate
|
1159490-85-3
|
98%
|
|
PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
|
T15383 |
Glesatinib hydrochloride
|
1123838-51-6
|
98%
|
|
Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO. Glesatinib hydrochloride is also a tyrosine kinase inhibitor. It antagonizes P...
|
T6378 |
AMG-458
|
913376-83-7
|
98%
|
|
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
|
T3512 |
S49076 HCl
|
1265966-31-1
|
98%
|
|
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
|
T15384 |
Glesatinib
|
936694-12-1
|
98%
|
|
Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multi...
|
T67859 |
N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenylpropanohydrazide
|
299405-67-7
|
98%
|
|
N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenylpropanohydrazide is a c-Met kinase inhibitor.
|
T10654 |
C-Met-IN-2
|
1635406-73-3
|
98%
|
|
c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.
|
T10653 |
C-met-IN-1
|
2084836-84-8
|
98%
|
|
c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.
|
T12417 |
PF-04217903 methanesulfonate
|
956906-93-7
|
98%
|
|
PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
|
T2349 |
BMS-754807
|
1001350-96-4
|
98%
|
|
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine ...
|
T37596 |
Terevalefim
|
1070881-42-3
|
98%
|
|
Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.
|
T9601 |
Tepotinib hydrochloride(1 : x)
|
1103508-80-0
|
98%
|
|
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
|
T11162 |
EGFR-IN-8
|
2407957-87-1
|
98%
|
|
EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.
|
T6154 |
SU11274
|
658084-23-2
|
|
|
SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
|
T2185 |
L-Ascorbic acid 2-phosphate trisodium
|
66170-10-3
|
100%
|
|
L-Ascorbic acid 2-phosphate (AA2P) is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays.
|
T7787 |
BMS817378
|
1174161-69-3
|
100%
|
|
BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).
|
T5414 |
Glumetinib
|
1642581-63-2
|
100%
|
|
Glumetinib (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).
|