fumarate

3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine.

Iron(II) fumarate (Iron Fumarate) is the iron(II) salt of fumaric acid, a reddish-orange powder, applied to supply iron intake.

Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir disoproxil fumarate is prescribed to treat HIV and chronic hepatitis B virus (HBV) in adults.

JTV-519 fumarate (K201 fumarate) is a SERCA blocker and partial agonist at the ryanodine receptor with antiarrhythmic and cardioprotective effects, improves sarcoplasmic reticulum calcium leakage, and may be useful in the study of anxiety disorders.

Org-13011 fumarate1 is an agonist of the 5-HT1A receptor and can be used to study neurological disorders.

Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-HT2), and α1-adrenergic receptors.Aplindore Fumarate is used in the study of Parkinson's disease and schizophrenia. Fumarate can be used to study Parkinson's and schizophrenia.

Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.

UB 165 fumarate is an agonist of the nAChR, a partial agonist of the α4β2 subtype, and a full agonist of the α3β2 subtype, with a Ki value of 0.27 nM for binding to [3H]-nicotine measured in rat brain.

KT-362 fumarate is a novel compound that acts as an antagonist of calcium channels, potassium channels and sodium channels.KT-362 fumarate causes vasodilation by affecting intracellular calcium mobilization in atrial muscle cells.KT-362 fumarate has a relaxing effect on femoral and basilar artery strips in rabbits.

LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fumarate has a low propensity to cross the blood brain barrier. LXE408 fumarate has the potential for visceral leishmaniasis (VL) research.

F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1].

Dimethyl fumarate (DMF), a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.

Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with antidepressant and anxiolytic.

Tepilamide fumarate (XP-23829) is an oral fumaric acid ester and is used in the research of moderate to severe chronic plaque psoriasis.

Diethyl fumarate is a decomposition product of the pesticide Malathion. Diethyl fumarate causes nonimmune contact urticaria on the skin.

Liarozole fumarate is used as a retinoic acid metabolism blocking agent (RAMBA) and an aromatase inhibitor.

VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.

Mitemcinal fumarate is a erythromycin derivative that is used to treat gastroesophageal reflux disease.

Desfesoterodine fumarate is a bio-active chemical. Detailed information has not been published.

Tegolimod fumarate is an immunomodulator [1].

Satavaptan fumarate is a selective antagonist of the non-peptide vasopressin V2 receptor.

(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium. It is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes

Bopindolol ((±)-Bopindolol) fumarate is an orally active β-adrenoceptor (ARs) antagonist with partial agonist activity that is non-selective for β1- and β2-ARs and has low affinity for the β3-AR subtype. Bopindolol fumarate is a precursor drug to Pindolol and can be used to study primary and renal vascular hypertension.

NS3861 fumarate is an agonist of nicotinic acetylcholine receptors (nAChRs). NS3861 fumarate is a partial agonist at α3β4 nAChR and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively[1].

Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. can induces upregulation of antioxidant gene expression.

S(-)-Bisoprolol fumarate, the S(-)-enantiomer of Bisoprolol fumarate, is a potent, selective, and orally active β1-adrenergic receptor blocker with minimal activity on β2-receptors. It holds potential for research in hypertension, coronary artery disease, and stable ventricular dysfunction [1] [2].

Oxetorone fumarate is a serotonin antagonist, antihistamine, and alpha-blocker. It was used as an antimigraine drug.

Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-associated protein 1.

Amitriptan fumarate is serotonin 5HT-1B/1D receptor agonist with anti-migraine activity.

AHR-5859 fumarate is a biochemical.

Linogliride fumarate is the fumarate salt of Linogliride. Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassium channels in the pancreatic beta cell membrane, thereby stimulating insulin secretion and improving glucose tolerance.

Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasing energy expenditure in cells.

Picumeterol fumarate is a potent and selective beta2-adrenoceptor agonist that acts as a bronchodilator.

Quetiapine-d8 Fumarate is a deuterated compound of Quetiapine Fumarate. Quetiapine Fumarate has a CAS number of 111974-72-2. Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.

Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase.

Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5.

Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma.

Cyanopindolol fumarate is a 5-HT receptor antagonist [1].

AH-9700 fumarate is a the salt form of AH-9700 and a biochemical which has been shown to improve abnormal frequent urination cystitis in a manner different from that of oxybutynin.

Eptapirone, also known as F11440, is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively).

VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).

Bencyclane Fumarate (Halidor) is a vasodilator that is effective against a variety of peripheral circulation disorders.

Levormeloxifene fumarate is an osteoporosis drug and selective estrogen receptor modulator (SERM).

Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).

Zicronapine (Lu 31-130) fumarate, an antipsychotic medication, exhibits potent pro-cognitive effects in animal models and holds promise for treating various neurological and psychiatric conditions. It acts as a strong antagonist at dopamine D1/D2 and serotonin 5-HT2A receptors, highlighting its potential therapeutic efficacy [1] [2].

Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor with antiproliferative activity and can be used to study cellular activity.

Dehydro amlodipine is a potential impurity found in commercial preparations of amlodipine. It is a degradation product formed during storage or when amlodipine is subjected to oxidative or acidic conditions or undergoes photo or electrochemical degradation.

Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.