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GSK-3

Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over 100 different proteins in a variety of different pathways. In mammals GSK-3 is encoded by two paralogous genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (diabetes mellitus type 2), Alzheimer's disease, inflammation, cancer, and bipolar disorder.
Cat No. product name
T21966 MeBIO MeBIO 是一种芳烃受体激动剂,对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
T3077 SB 216763 SB216763 is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).
T14072 A-443654 A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T2166 TWS119 TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
T6169 Indirubin Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
T2310 CHIR-99021 CHIR-99021 (CT99021) is a GSK-3α/β inhibitor (IC50: 10/6.7 nM).
T9025 KY19382 KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It activates Wnt/β-catenin signaling through i...
T2873 Ginsenoside Rg2 Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
T6205 AT7519 AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.
T1260 Cromolyn sodium Cromolyn sodium is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
T6659 SB 415286 SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.
T1778 AT7519 Hydrochloride AT7519 hydrochloride is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
T0256 Citric acid trilithium salt tetrahydrate Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
T6049 SNS-032 SNS-032 is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and n...
T3385 Gypenoside XVII Gypenoside XVII confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/...
T6787 BIO-acetoxime BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
T1917 GSK 3 Inhibitor IX BIO is a specific inhibitor of GSK-3.
T0704 Cyanoacetohydrazide Cyanoacetohydrazide is an anti-TB drug.
T6350 CHIR-124 CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
T10172 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s:...
T1965 Bikinin Bikinin, a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
T6312 R547 R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1...
T5200 Indirubin-3'-monoxime Indirubin-3'-oxime is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).
T7426 ALSTERPAULLONE Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
T2378 RGB-286638 free base RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
T6940 PHA-767491 hydrochloride PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity ...
T14066 9-ING-41 9-ING-41 is a glycogen synthase kinase-3 inhibitor.
T11447 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
T9138 Indirubin-3′-oxime Indirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
T2S0606 Bakkenolide A Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T1881 AR-A014418 AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor.
T1957 AZD2858 AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.
T2247 KenPaullone Kenpaullone, a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through incr...
T2261 IM-12 IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.
T2695 TBB TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
T2608 CHIR-98014 CHIR-98014 is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
T24111 GSK3i XIII GSK3i XIII is a GSK-3 ATP-binding site inhibitor.
T7473 5-Bromoindole 5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate
T9178 (E/Z)-GSK-3β inhibitor 1 GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.
T8908 4-Chloro-2'-bromoacetophenone 4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).
T8605 GS87 GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.
TN1819 Kaempferol 3-neohesperidoside Kaempferol 3-neohesperidoside is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.
TMA0291 Dehydroglyasperin D Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
T11471 GSK-3β inhibitor 2 GSK-3β inhibitor 2 is a selective and orally active GSK-3β inhibitor (IC50: 1.1 nM). GSK-3β inhibitor 2 can cross the blood-brain barrier with the potential for ...
T11468 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is a GSK-3 inhibitor.
T11467 GSK-3β inhibitor 1 GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.
T10786 Charantin Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
T10606 BRD0705 BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) ver...
T10202 A 1070722 A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumulat...
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
MeBIO
T21966
MeBIO 是一种芳烃受体激动剂,对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
SB 216763
T3077
SB216763 is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).
A-443654
T14072
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
TWS119
T2166
TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
Indirubin
T6169
Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
CHIR-99021
T2310
CHIR-99021 (CT99021) is a GSK-3α/β inhibitor (IC50: 10/6.7 nM).
KY19382
T9025
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It activates Wnt/β-catenin signaling through...
Ginsenoside Rg2
T2873
Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
AT7519
T6205
AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.
Cromolyn sodium
T1260
Cromolyn sodium is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
SB 415286
T6659
SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.
AT7519 Hydrochloride
T1778
AT7519 hydrochloride is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
Citric acid trilithium salt tetrahydrate
T0256
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
SNS-032
T6049
SNS-032 is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and n...
Gypenoside XVII
T3385
Gypenoside XVII confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2...
BIO-acetoxime
T6787
BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
GSK 3 Inhibitor IX
T1917
BIO is a specific inhibitor of GSK-3.
Cyanoacetohydrazide
T0704
Cyanoacetohydrazide is an anti-TB drug.
CHIR-124
T6350
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
5-Iodo-indirubin-3'-monoxime
T10172
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s...
Bikinin
T1965
Bikinin, a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
R547
T6312
R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase...
Indirubin-3'-monoxime
T5200
Indirubin-3'-oxime is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).
ALSTERPAULLONE
T7426
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
RGB-286638 free base
T2378
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
PHA-767491 hydrochloride
T6940
PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity...
9-ING-41
T14066
9-ING-41 is a glycogen synthase kinase-3 inhibitor.
GNF4877
T11447
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and i...
Indirubin-3′-oxime
T9138
Indirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Bakkenolide A
T2S0606
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
AR-A014418
T1881
AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor.
AZD2858
T1957
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.
KenPaullone
T2247
Kenpaullone, a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through incr...
IM-12
T2261
IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.
TBB
T2695
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
CHIR-98014
T2608
CHIR-98014 is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
GSK3i XIII
T24111
GSK3i XIII is a GSK-3 ATP-binding site inhibitor.
5-Bromoindole
T7473
5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate
(E/Z)-GSK-3β inhibitor 1
T9178
GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.
4-Chloro-2'-bromoacetophenone
T8908
4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).
GS87
T8605
GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.
Kaempferol 3-neohesperidoside
TN1819
Kaempferol 3-neohesperidoside is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.
Dehydroglyasperin D
TMA0291
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
GSK-3β inhibitor 2
T11471
GSK-3β inhibitor 2 is a selective and orally active GSK-3β inhibitor (IC50: 1.1 nM). GSK-3β inhibitor 2 can cross the blood-brain barrier with the potential f...
GSK-3 inhibitor 1
T11468
GSK-3 inhibitor 1 is a GSK-3 inhibitor.
GSK-3β inhibitor 1
T11467
GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.
Charantin
T10786
Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
BRD0705
T10606
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) ...
A 1070722
T10202
A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumul...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
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