JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .

Cat No.	product name
T2234	SC-202671	TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
T2668	JNK-IN-8	JNK-IN-8 is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ ...
T2675	AS 602801	AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.
T3079	GSK1838705A	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
T3109	PyrazolanthroneHOT	SP600125 is a JNK1/2/3 inhibitor (IC50: 40/40/90 nM) and 10-fold higher selectivity than MKK4, 25-fold higher selectivity than MKK3, MKK6, PKCα, and PKB.
T3200	DB07268	DB07268 is a potent and selective JNK1 inhibitor.
T3598	JNK-IN-7	JNK-IN-7 is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
T3627	IQ-1S	IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and car...
T4082	Astragaloside
T6758	Anisomycin	Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 8...
T6784	BI-78D3	BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
T7008	Vacquinol-1	Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
T3S0737	Flavokawain A	1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-m...
T4S1962	beta-Asarone	1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in ...
T4S2326	Cornuside	1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human e...
T5574	Guggulsterone E&Z	Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T5833	CC-401 Hydrochloride	CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potential antineoplastic activit...
TQ0089	Juglanin	Juglanin is a JNK activator.
T5094	IRAK inhibitor 1	IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
TN1072	Lappaol A	Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also...
TN1879	Lucidenic acid A	Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulat...
TN2039	Panaxydol	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 M...
TN1013	Cucurbitacin D	Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
TN1493	Chrysosplenol D	Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
TN1557	Decursinol angelate	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of t...
TN1702	Glycycoumarin	Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
TN1775	Isocryptotanshinone	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negativ...
TN1918	Medicarpin	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of ...
TN2290	Uvaol	Uvaol has anti-inflammatory, anti-proliferative, and vasorelaxing activities.
TN1068	Tricin	Tricin is evaluated as a type of tyrosinase inhibitor
TN1403	Arjunolic acid	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the deve...
TN1448	Bornyl acetate	Bornyl acetate shows highly active whitening and antioxidant activities, has potential applications in cosmeceutical materials.
TN1677	Gartanin	Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through...
T10937	D-JNKI-1	D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.
T7677	JNK Inhibitor VIII	JNK Inhibitor VIII is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively).
T8477	IQ3	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity i...
T14895	Tanzisertib	Tanzisertib (CC-930) is a potent inhibitor of JNK1/2/3 (IC50s: 61/7/6 nM).
T12828	Salicortin	Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activit...
T13018	SU3327	SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
TP2145	JTP10-△-R9 TFA	JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.
TP2146	JTP10-△-TATi TFA	JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.
T11707	JAK2/FLT3-IN-1	JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor w...
T16927	SR-3306	SR-3306 is a potent and highly inhibitor of brain penetrant JNK.
TP1430	DTP3 TFA	DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.
T2S1040	Jolkinolide B	Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part,...
T2S1975	Ponicidin	Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...
T3S0006	Methyl ferulate	Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first...
T3S0209	Vincristine	Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristi...
TL0014	Pinusolide	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
TL0016	Sulforaphene	Sulforaphene may be a potential anti- triple negative breast cancer natural compound and its /\''antiproliferation effects may be mediated by tumor suppressor E...