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MAPK JNK

JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .
Cat No. product name
T2234 SC-202671 TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
T2668 JNK-IN-8 JNK-IN-8 is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ ...
T2675 AS 602801 AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.
T3079 GSK1838705A GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
T3109 PyrazolanthroneHOT SP600125 is a JNK1/2/3 inhibitor (IC50: 40/40/90 nM) and 10-fold higher selectivity than MKK4, 25-fold higher selectivity than MKK3, MKK6, PKCα, and PKB.
T3200 DB07268 DB07268 is a potent and selective JNK1 inhibitor.
T3598 JNK-IN-7 JNK-IN-7 is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
T3627 IQ-1S IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and car...
T4082 Astragaloside
T6758 Anisomycin Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 8...
T6784 BI-78D3 BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
T7008 Vacquinol-1 Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
T3S0737 Flavokawain A 1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-m...
T4S1962 beta-Asarone 1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in ...
T4S2326 Cornuside 1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human e...
T5574 Guggulsterone E&Z Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T5833 CC-401 Hydrochloride CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potential antineoplastic activit...
TQ0089 Juglanin Juglanin is a JNK activator.
T5094 IRAK inhibitor 1 IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
TN1072 Lappaol A Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also...
TN1879 Lucidenic acid A Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulat...
TN2039 Panaxydol Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 M...
TN1013 Cucurbitacin D Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
TN1493 Chrysosplenol D Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
TN1557 Decursinol angelate Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of t...
TN1702 Glycycoumarin Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
TN1775 Isocryptotanshinone Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negativ...
TN1918 Medicarpin Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of ...
TN2290 Uvaol Uvaol has anti-inflammatory, anti-proliferative, and vasorelaxing activities.
TN1068 Tricin Tricin is evaluated as a type of tyrosinase inhibitor
TN1403 Arjunolic acid Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the deve...
TN1448 Bornyl acetate Bornyl acetate shows highly active whitening and antioxidant activities, has potential applications in cosmeceutical materials.
TN1677 Gartanin Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through...
T10937 D-JNKI-1 D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.
T7677 JNK Inhibitor VIII JNK Inhibitor VIII is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively).
T8477 IQ3 IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity i...
T14895 Tanzisertib Tanzisertib (CC-930) is a potent inhibitor of JNK1/2/3 (IC50s: 61/7/6 nM).
T12828 Salicortin Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activit...
T13018 SU3327 SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
TP2145 JTP10-△-R9 TFA JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.
TP2146 JTP10-△-TATi TFA JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.
T11707 JAK2/FLT3-IN-1 JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor w...
T16927 SR-3306 SR-3306 is a potent and highly inhibitor of brain penetrant JNK.
TP1430 DTP3 TFA DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.
T2S1040 Jolkinolide B Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part,...
T2S1975 Ponicidin Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...
T3S0006 Methyl ferulate Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first...
T3S0209 Vincristine Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristi...
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
TL0016 Sulforaphene Sulforaphene may be a potential anti- triple negative breast cancer natural compound and its /\''antiproliferation effects may be mediated by tumor suppressor E...
SC-202671
T2234CAS 312917-14-9
TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
JNK-IN-8
T2668CAS 1410880-22-6
JNK-IN-8 is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ ...
AS 602801
T2675CAS 848344-36-5
AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.
GSK1838705A
T3079CAS 1116235-97-2
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
Pyrazolanthrone HOT
T3109CAS 129-56-6
SP600125 is a JNK1/2/3 inhibitor (IC50: 40/40/90 nM) and 10-fold higher selectivity than MKK4, 25-fold higher selectivity than MKK3, MKK6, PKCα, and PKB.
DB07268
T3200CAS 929007-72-7
DB07268 is a potent and selective JNK1 inhibitor.
JNK-IN-7
T3598CAS 1408064-71-0
JNK-IN-7 is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
IQ-1S
T3627CAS 23146-22-7
IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and car...
Astragaloside
T4082CAS T4082
Anisomycin
T6758CAS 22862-76-6
Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 8...
BI-78D3
T6784CAS 883065-90-5
BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
Vacquinol-1
T7008CAS 5428-80-8
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
Flavokawain A
T3S0737CAS 3420-72-2
1. Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-m...
beta-Asarone
T4S1962CAS 5273-86-9
1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in ...
Cornuside
T4S2326CAS 131189-57-6
1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human e...
Guggulsterone E&Z
T5574CAS 95975-55-6
Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
CC-401 Hydrochloride
T5833CAS 1438391-30-0
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potential antineoplastic activit...
Juglanin
TQ0089CAS 5041-67-8
Juglanin is a JNK activator.
IRAK inhibitor 1
T5094CAS 1042224-63-4
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
Lappaol A
TN1072CAS 62333-08-8
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also...
Lucidenic acid A
TN1879CAS 95311-94-7
Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulat...
Panaxydol
TN2039CAS 72800-72-7
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 M...
Cucurbitacin D
TN1013CAS 3877-86-9
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
Chrysosplenol D
TN1493CAS 14965-20-9
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
Decursinol angelate
TN1557CAS 130848-06-5
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of t...
Glycycoumarin
TN1702CAS 94805-82-0
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
Isocryptotanshinone
TN1775CAS 22550-15-8
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negativ...
Medicarpin
TN1918CAS 32383-76-9
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of ...
Uvaol
TN2290CAS 545-46-0
Uvaol has anti-inflammatory, anti-proliferative, and vasorelaxing activities.
Tricin
TN1068CAS 520-32-1
Tricin is evaluated as a type of tyrosinase inhibitor
Arjunolic acid
TN1403CAS 465-00-9
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the deve...
Bornyl acetate
TN1448CAS 5655-61-8
Bornyl acetate shows highly active whitening and antioxidant activities, has potential applications in cosmeceutical materials.
Gartanin
TN1677CAS 33390-42-0
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through...
D-JNKI-1
T10937CAS 1445179-97-4
D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.
JNK Inhibitor VIII
T7677CAS 894804-07-0
JNK Inhibitor VIII is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively).
IQ3
T8477CAS 312538-03-7
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity i...
Tanzisertib
T14895CAS 899805-25-5
Tanzisertib (CC-930) is a potent inhibitor of JNK1/2/3 (IC50s: 61/7/6 nM).
Salicortin
T12828CAS 1887055-63-1
Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activit...
SU3327
T13018CAS 40045-50-9
SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
JTP10-△-R9 TFA
TP2145CAS NA
JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.
JTP10-△-TATi TFA
TP2146CAS NA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.
JAK2/FLT3-IN-1
T11707CAS 2387765-27-5
JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor w...
SR-3306
T16927CAS 1128096-91-2
SR-3306 is a potent and highly inhibitor of brain penetrant JNK.
DTP3 TFA
TP1430CAS TP1430
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.
Jolkinolide B
T2S1040CAS 37905-08-1
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part,...
Ponicidin
T2S1975CAS 52617-37-5
Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infecti...
Methyl ferulate
T3S0006CAS 22329-76-6
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first...
Vincristine
T3S0209CAS 57-22-7
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristi...
Pinusolide
TL0014CAS 31685-80-0
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
Sulforaphene
TL0016CAS 592-95-0
Sulforaphene may be a potential anti- triple negative breast cancer natural compound and its /\''antiproliferation effects may be mediated by tumor suppressor E...