LPL Receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene).

Cat. No.	Product name	CAS No.	Purity
T17237	VPC 23019	449173-19-7	98%
T17237	VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T7393	ONO-7300243	638132-34-0	98%
T7393	ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
T6085	PF-543	1415562-82-1	98%
T6085	PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T6347	Ki16198	355025-13-7	98%
T6347	Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
T61112	SLF1081851	2763730-97-6	98%
T61112	SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
T12086	Mocravimod hydrochloride	509088-69-1	98%
T12086	Mocravimod hydrochloride is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).
T12821	S1PR1 modulator 1	2328109-05-1	98%
T12821	S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
T15031	CYM50260	1355026-60-6
T15031	CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R a...
T2026	CYM5442	1094042-01-9	96.65%
T2026	CYM5442 is an S1P agonist, targeting to Sphingosine.
T7360	GSK2018682	1034688-30-6	97.78%
T7360	GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T3258	Ponesimod	854107-55-4	98.01%
T3258	Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
T9199	GLPG2938	2130996-00-6	98.1%
T9199	GLPG2938 is a potent and selective antagonist of S1P2.
T3961	CYM-5541	945128-26-7	98.39%
T3961	CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T6108	Ki16425	355025-24-0	98.54%
T6108	Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T4016	BMS-986020	1257213-50-5	98.61%
T4016	BMS-986020 is a selective antagonist of LPA1.
T22703	CYM-5520	1449747-00-5	98.72%
T22703	noncompetitive allosteric agonist of S1P2
T15629	JTE-013	383150-41-2	98.87%
T15629	JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T28169	NIBR-0213	1233332-14-3	98.87%
T28169	NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
T6403	Siponimod	1230487-00-9	99.29%
T6403	BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specifi...
T15032	CYM50308	1345858-76-5	99.43%
T15032	CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...