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LPL Receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene).
Cat No. product name
T12086 Mocravimod hydrochloride Mocravimod hydrochloride 是 1-磷酸鞘氨醇受体 1 型 (S1PR1) 的有效和口服活性激动剂。
TQ0227 Etrasimod Etrasimod is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
T7360 GSK2018682 GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T8840 PF-543 hydrochloride PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
T2000 AM095 AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
T10293 AM095 free acid AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
T2539 Fingolimod hydrochloride Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T0307 Tyloxapol Tyloxapol is a non-ionic liquid polymer used as a surfactant.
T17237 VPC 23019 VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T7939 Fingolimod Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T4278 AM966 AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
T6403 Siponimod BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specifi...
T9199 GLPG2938 GLPG2938 is a potent and selective antagonist of S1P2.
T9464 CYM50358 N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 ...
T15629 JTE-013 JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T17183 TY-52156 TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T22703 CYM-5520 noncompetitive allosteric agonist of S1P2
T15031 CYM50260 CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S...
T15032 CYM50308 CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
T22834 H2L 5765834 H2L 5765834 is a lysophosphatidic acid receptors antagonist
T28169 NIBR-0213 NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
T4016 BMS-986020 BMS-986020 is a selective antagonist of LPA1.
T7393 ONO-7300243 ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
T4031 S1p receptor agonist 1 An S1P receptor agonist.
T3961 CYM-5541 CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T6347 Ki16198 Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
T6108 Ki16425 Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T10305 Amiselimod hydrochloride Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T6923 Ozanimod Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, M...
T6085 PF-543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T2171 SEW​2871 Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
T7832 Ibrolipim Ibrolipim attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
T2026 CYM5442 CYM5442 is an S1P agonist, targeting to Sphingosine.
T3258 Ponesimod Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
Mocravimod hydrochloride
T12086
Mocravimod hydrochloride 是 1-磷酸鞘氨醇受体 1 型 (S1PR1) 的有效和口服活性激动剂。
Etrasimod
TQ0227
Etrasimod is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
GSK2018682
T7360
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
PF-543 hydrochloride
T8840
PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
AM095
T2000
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
AM095 free acid
T10293
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
Fingolimod hydrochloride
T2539
Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
Tyloxapol
T0307
Tyloxapol is a non-ionic liquid polymer used as a surfactant.
VPC 23019
T17237
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
Fingolimod
T7939
Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
AM966
T4278
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
Siponimod
T6403
BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specifi...
GLPG2938
T9199
GLPG2938 is a potent and selective antagonist of S1P2.
CYM50358
T9464
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50...
JTE-013
T15629
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
TY-52156
T17183
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
CYM-5520
T22703
noncompetitive allosteric agonist of S1P2
CYM50260
T15031
CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S...
CYM50308
T15032
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
H2L 5765834
T22834
H2L 5765834 is a lysophosphatidic acid receptors antagonist
NIBR-0213
T28169
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
BMS-986020
T4016
BMS-986020 is a selective antagonist of LPA1.
ONO-7300243
T7393
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
S1p receptor agonist 1
T4031
An S1P receptor agonist.
CYM-5541
T3961
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
Ki16198
T6347
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 ...
Ki16425
T6108
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
Amiselimod hydrochloride
T10305
Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
Ozanimod
T6923
Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, M...
PF-543
T6085
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
SEW​2871
T2171
Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
Ibrolipim
T7832
Ibrolipim attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
CYM5442
T2026
CYM5442 is an S1P agonist, targeting to Sphingosine.
Ponesimod
T3258
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...