T10385 |
ASP-4058
|
952565-91-2
|
98%
|
|
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
|
T63047 |
SLP9101555
|
T63047
|
98%
|
|
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
|
T17237 |
VPC 23019
|
449173-19-7
|
98%
|
|
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
|
T4031 |
S1p receptor agonist 1
|
1514888-56-2
|
98%
|
|
An S1P receptor agonist.
|
T8840 |
PF-543 hydrochloride
|
1706522-79-3
|
98%
|
|
PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
|
T10293 |
AM095 free acid
|
1228690-36-5
|
98%
|
|
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
|
T15031 |
CYM50260
|
1355026-60-6
|
98%
|
|
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R a...
|
T7939 |
Fingolimod
|
162359-55-9
|
98%
|
|
Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
|
T6923 |
Ozanimod
|
1306760-87-1
|
98%
|
|
Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, M...
|
T17183 |
TY-52156
|
934369-14-9
|
98%
|
|
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
|
T10305 |
Amiselimod hydrochloride
|
942398-84-7
|
98%
|
|
Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
|
T2171 |
SEW2871
|
256414-75-2
|
98%
|
|
Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
|
T22834 |
H2L 5765834
|
420841-84-5
|
98%
|
|
H2L 5765834 is a lysophosphatidic acid receptors antagonist
|
T7832 |
Ibrolipim
|
133208-93-2
|
98%
|
|
Ibrolipim attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
|
T12821 |
S1PR1 modulator 1
|
2328109-05-1
|
98%
|
|
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
|
T15032 |
CYM50308
|
1345858-76-5
|
98%
|
|
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
|
T2539 |
Fingolimod hydrochloride
|
162359-56-0
|
98%
|
|
Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
|
TQ0227 |
Etrasimod
|
1206123-37-6
|
98%
|
|
Etrasimod is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
|
T15629 |
JTE-013
|
383150-41-2
|
98%
|
|
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
|
T28169 |
NIBR-0213
|
1233332-14-3
|
98%
|
|
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
|