LPL Receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene).

Cat. No.	Product name	CAS No.	Purity
T10385	ASP-4058	952565-91-2	98%
T10385	ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
T63047	SLP9101555	T63047	98%
T63047	SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
T17237	VPC 23019	449173-19-7	98%
T17237	VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T4031	S1p receptor agonist 1	1514888-56-2	98%
T4031	An S1P receptor agonist.
T8840	PF-543 hydrochloride	1706522-79-3	98%
T8840	PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
T10293	AM095 free acid	1228690-36-5	98%
T10293	AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
T15031	CYM50260	1355026-60-6	98%
T15031	CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R a...
T7939	Fingolimod	162359-55-9	98%
T7939	Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T6923	Ozanimod	1306760-87-1	98%
T6923	Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, M...
T17183	TY-52156	934369-14-9	98%
T17183	TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T10305	Amiselimod hydrochloride	942398-84-7	98%
T10305	Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T2171	SEW2871	256414-75-2	98%
T2171	Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
T22834	H2L 5765834	420841-84-5	98%
T22834	H2L 5765834 is a lysophosphatidic acid receptors antagonist
T7832	Ibrolipim	133208-93-2	98%
T7832	Ibrolipim attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
T12821	S1PR1 modulator 1	2328109-05-1	98%
T12821	S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
T15032	CYM50308	1345858-76-5	98%
T15032	CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
T2539	Fingolimod hydrochloride	162359-56-0	98%
T2539	Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
TQ0227	Etrasimod	1206123-37-6	98%
TQ0227	Etrasimod is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
T15629	JTE-013	383150-41-2	98%
T15629	JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T28169	NIBR-0213	1233332-14-3	98%
T28169	NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.