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LPL Receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene).
Cat. No. Product name CAS No. Purity Chemical Structure
T10385 ASP-4058 952565-91-2 98%
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
T63047 SLP9101555 T63047 98%
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
T17237 VPC 23019 449173-19-7 98%
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T4031 S1p receptor agonist 1 1514888-56-2 98%
An S1P receptor agonist.
T8840 PF-543 hydrochloride 1706522-79-3 98%
PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
T10293 AM095 free acid 1228690-36-5 98%
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
T15031 CYM50260 1355026-60-6 98%
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R a...
T7939 Fingolimod 162359-55-9 98%
Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T6923 Ozanimod 1306760-87-1 98%
Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, M...
T17183 TY-52156 934369-14-9 98%
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T10305 Amiselimod hydrochloride 942398-84-7 98%
Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T2171 SEW​2871 256414-75-2 98%
Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
T22834 H2L 5765834 420841-84-5 98%
H2L 5765834 is a lysophosphatidic acid receptors antagonist
T7832 Ibrolipim 133208-93-2 98%
Ibrolipim attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
T12821 S1PR1 modulator 1 2328109-05-1 98%
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
T15032 CYM50308 1345858-76-5 98%
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
T2539 Fingolimod hydrochloride 162359-56-0 98%
Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
TQ0227 Etrasimod 1206123-37-6 98%
Etrasimod is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
T15629 JTE-013 383150-41-2 98%
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T28169 NIBR-0213 1233332-14-3 98%
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
ASP-4058
T10385
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
SLP9101555
T63047
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
VPC 23019
T17237
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
S1p receptor agonist 1
T4031
An S1P receptor agonist.
PF-543 hydrochloride
T8840
PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
AM095 free acid
T10293
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
CYM50260
T15031
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R a...
Fingolimod
T7939
Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
Ozanimod
T6923
Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, M...
TY-52156
T17183
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
Amiselimod hydrochloride
T10305
Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
SEW​2871
T2171
Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
H2L 5765834
T22834
H2L 5765834 is a lysophosphatidic acid receptors antagonist
Ibrolipim
T7832
Ibrolipim attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
S1PR1 modulator 1
T12821
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
CYM50308
T15032
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
Fingolimod hydrochloride
T2539
Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
Etrasimod
TQ0227
Etrasimod is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
JTE-013
T15629
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
NIBR-0213
T28169
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
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