Home Tools
Log in
Cart

P-gp

P-glycoprotein (P-gp) is a plasma membrane protein which acts as a localized drug transport mechanism, actively exporting drugs out of the cell. The effects of P-gp on the distribution, metabolism and excretion of drugs — including protease inhibitors — in the body is great.
Cat No. product name
T12540 Pristinamycin IA Pristinamycin IA 是 P-糖蛋白的底物,也是一种环肽类大环内酯抗生素。
T3S0012 Coniferyl ferulate Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental...
T2S0223 Isosinensetin 1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
TCS2336 Evodine 1. Evodine has antinociceptive activity.
T16561 Polyoxyethylene stearate Polyoxyethylene stearate is an agent of non-ionic emulsifying.
T4034 Solamargine Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
TN1757 Hypophyllanthin Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
T2S0271 Voacamine Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action i...
T2S0410 Euphorbia factor L1 1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 an...
T4A2399 Cinobufotalin Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
T2S1200 Sinapine 1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
T0100L Atazanavir Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T0351 Risperidone Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
TN1525 Convallatoxin Convallatoxin is a natural product
T4059 Selamectin Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. I...
T3002 Piperine Piperine (1-Piperoylpiperidine), a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
T1222 Trifluoperazine dihydrochloride Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T2893 Muscone Muscone is an organic compound that is the primary contributor to the odor of musk.
T3868 Agnuside Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gly...
TN1651 Furanodiene Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3392 Sinapine thiocyanate Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
T1010 Verapamil hydrochloride Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T4085 Paris saponin VII Chonglou saponin VII shows inhibitory effects on cell proliferation.
T2657 Elacridar Elacridar (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.
T9601 Tepotinib hydrochloride(1 : x) Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
TJS1159 Chrysosplenetin 1. Chrysosplenetin is a metabolic inhibitor of artemisinin.
T16339 Norverapamil hydrochloride Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glyc...
T1634 Glibenclamide Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T8389 Trifluoperazine Trifluoperazine is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T2799 (20S)-Protopanaxadiol (20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
T11578L Encequidar mesylate Encequidar mesylate is a competitive P-glycoprotein inhibitor.
T11071 Dofequidar fumarate Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated prote...
T0100 Atazanavir sulfate Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS...
T0012 Cinchonine Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narc...
T13383 Zamicastat Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0...
T2A2486 3',​4',​5',​5,​7-​Pentamethoxyflavone 3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adju...
TN2554 1-Monopalmitin 1-Monopalmitin has dielectric properties. 1-Monopalmitin inhibits the P-glycoprotein activity in intestinal Caco-2 cells.
T8426 Encequidar Encequidar is a potent and selective P-glycoprotein inhibitor.
T9173 HM-30181 mesylate monohydrate HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.
TN2263 Tenacigenin B Standard reference
TN2233 Spathulenol Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possib...
TN2257 Tanshinone IIB Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN1425 Bacoside A3 Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
TN1099 Dihydroevocarpine Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a...
TN1072 Lappaol A Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also ...
TN1048 Cnidilin Cnidilin has high BBB permeability and has pharmacokinetic potentials for the treatment of central nervous system diseases.
TMA2270 Alisol F 24-acetate Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX...
TN2726 Jatrophane 5 Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-Tx...
TN2727 Jatrophane 2 2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-fee...
TN4411 Lappaol F 1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.
2. Lap...
Pristinamycin IA
T12540
Pristinamycin IA 是 P-糖蛋白的底物,也是一种环肽类大环内酯抗生素。
coniferyl ferulate
T3S0012
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental...
Isosinensetin
T2S0223
1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
Evodine
TCS2336
1. Evodine has antinociceptive activity.
Polyoxyethylene stearate
T16561
Polyoxyethylene stearate is an agent of non-ionic emulsifying.
Solamargine
T4034
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
Hypophyllanthin
TN1757
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
Voacamine
T2S0271
Voacamine is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action i...
Euphorbia factor L1
T2S0410
1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 an...
Cinobufotalin
T4A2399
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
Sinapine
T2S1200
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
Atazanavir
T0100L
Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
Risperidone
T0351
Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Convallatoxin
TN1525
Convallatoxin is a natural product
Selamectin
T4059
Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. I...
Piperine
T3002
Piperine (1-Piperoylpiperidine), a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Trifluoperazine dihydrochloride
T1222
Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
Muscone
T2893
Muscone is an organic compound that is the primary contributor to the odor of musk.
Agnuside
T3868
Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gly...
Furanodiene
TN1651
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
Sinapine thiocyanate
T3392
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
Verapamil hydrochloride
T1010
Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.
Paris saponin VII
T4085
Chonglou saponin VII shows inhibitory effects on cell proliferation.
Elacridar
T2657
Elacridar (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.
Tepotinib hydrochloride(1 : x)
T9601
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
Chrysosplenetin
TJS1159
1. Chrysosplenetin is a metabolic inhibitor of artemisinin.
Norverapamil hydrochloride
T16339
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-gly...
Glibenclamide
T1634
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Trifluoperazine
T8389
Trifluoperazine is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
(20S)-Protopanaxadiol
T2799
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
Encequidar mesylate
T11578L
Encequidar mesylate is a competitive P-glycoprotein inhibitor.
Dofequidar fumarate
T11071
Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated prote...
Atazanavir sulfate
T0100
Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS...
Cinchonine
T0012
Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narc...
Zamicastat
T13383
Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17...
3',​4',​5',​5,​7-​Pentamethoxyflavone
T2A2486
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adju...
1-Monopalmitin
TN2554
1-Monopalmitin has dielectric properties. 1-Monopalmitin inhibits the P-glycoprotein activity in intestinal Caco-2 cells.
Encequidar
T8426
Encequidar is a potent and selective P-glycoprotein inhibitor.
HM-30181 mesylate monohydrate
T9173
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.
Tenacigenin B
TN2263
Standard reference
Spathulenol
TN2233
Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possib...
Tanshinone IIB
TN2257
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
Bacoside A3
TN1425
Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
Dihydroevocarpine
TN1099
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a...
Lappaol A
TN1072
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also ...
Cnidilin
TN1048
Cnidilin has high BBB permeability and has pharmacokinetic potentials for the treatment of central nervous system diseases.
Alisol F 24-acetate
TMA2270
Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX...
Jatrophane 5
TN2726
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-Tx...
Jatrophane 2
TN2727
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-fee...
Lappaol F
TN4411
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lap...
1 2