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Cat No. | Product Name | Synonyms | Targets |
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T19206 | β-Lactamase-IN-1 | 4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one,beta-lactamase-IN-1 | Antibacterial |
β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) is a β-Lactamase inhibitor and targets the infection of Neisseria gonorrhoeae. | |||
T35427 | β-Lactamase-IN-2 | Antibacterial | |
β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects. | |||
T38476 | Metallo β-lactamase ligand 1 | Antibacterial | |
Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities. | |||
T39865 | β-Lactamase-IN-6 | ||
β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity. | |||
T38956 | β-Lactamase-IN-5 | ||
β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections. | |||
T38955 | β-Lactamase-IN-4 | ||
β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections. | |||
T60387 | β-Lactamase-IN-8 | ||
β-Lactamase-IN-8 (compound 20) is a potent and oral bioavailable broad-spectrum cyclic boronate β-lactamase inhibitor that can be used for researching antibacteria [1]. | |||
T60797 | β-Lactamase-IN-7 | ||
β-Lactamase-IN-7 (compound 14) effectively inhibit Klebsiella pneumoniae that is a potent inhibitor of VIM-Type metallo-β-lactamase with Ki values of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively [1]. | |||
T61173 | Metallo-β-lactamase-IN-5 | ||
Metallo-β-lactamase-IN-5 (compound 5c) is a powerful inhibitor of metallo-β-lactamases (MBLs). Its inhibitory activity against MBLs NDM-1 and VIM-1 has been demonstrated. With an IC50 value of 45 μg/mL, Metallo-β-lactama... | |||
T60494 | Metallo-β-lactamase-IN-7 | ||
Metallo-β-lactamase-IN-7 is a potent inhibitor of VIM -Type metallo-β-lactamase with IC 50 s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5, respectively. Metallo-β-lactamase-IN-7 also enhances the antibacter... | |||
T60282 | Metallo-β-lactamase-IN-3 | ||
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor that has the potential to restore the activity of current β-lactam antibiotics and to offer an orthogonal strategy to the discovery ... | |||
T60914 | Metallo-β-lactamase-IN-8 | ||
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum metallo-β-lactamases (MβLs) inhibitor with antibacterial activity. The IC50 values of Metallo-β-lactamase-IN-8 against L1, Imi... | |||
T79435 | Metallo-β-lactamase-IN-11 | ||
Metallo-β-lactamase-IN-11 (compound 5f), a potent inhibitor of Metallo-β-lactamases (MBLs), demonstrates efficacy against the bacterial metallophyllactamase CphA with an IC50 value of 45 µM. At a concentration of 10 µM, ... | |||
T60370 | Metallo-β-lactamase-IN-2 | ||
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor with IC 50 values of 0.1 μM for VIM-1, 1.3 μM for NDM-1 and 5.0 μM for IMP-7, respectively [1]. | |||
T60239 | Metallo-β-lactamase-IN-6 | ||
Metallo-β-lactamase-IN-6 is a highly effective inhibitor of VIM-Type metallo-β-lactamase, demonstrating IC 50 values of 0.56 μM, 29.50 μM, and 5.78 μM for VIM-2, VIM-1, and VIM-5, respectively. In addition, Metallo-β-lac... | |||
T60694 | Metallo-β-lactamase-IN-4 | ||
Metallo-β-lactamase-IN-4 (compound 40) is a potent inhibitor of metallo-β-lactamases (MBL) with IC 50 values of 0.5 μM, 2.1 μM, and 3.3 μM for VIM-1, NDM-1 and IMP-7, respectively [1]. | |||
T72261 | Metallo-β-lactamase-IN-9 | ||
Metallo-β-lactamase-IN-9 (Compound 23) serves as a broad-spectrum inhibitor of metallo-beta-lactamases (MBL), exhibiting inhibition constants (IC50) of 35 nM for NDM-1, 269 nM for VIM-1, and 369 nM for IMP-1 [1]. | |||
T14979 | Clavulanate lithium | Clavulanic acid lithium | Antibacterial |
Clavulanate lithium (Clavulanic acid lithium) is an inhibitor of β-lactamase. | |||
T1550 | Thiamphenicol | Dextrosulphenidol,Thiophenicol | Antibacterial , Antibiotic |
Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent. | |||
T1305 | Ceftazidime | GR20263 | Antibacterial , Antibiotic |
Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity. | |||
T8620 | Piperacillin | Pipril,Pipracil,Pipercillin | Antibacterial |
Piperacillin (Pipercillin) is a semisynthetic penicillin with wide spectrum of antimicrobial activity(particularly pseudomonas strains) | |||
T2583 | Cilastatin | MK0791 | Proteasome , Antibacterial , Antibiotic |
Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cila... | |||
T1224 | Cefuroxime sodium | Anaptivan,Cefuroxime sodium salt,Biociclin | Antibacterial , Antibiotic |
Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic with bactericidal activity. Cefuroxime sodium (Cefuroxime... | |||
T1031 | Cloxacillin sodium monohydrate | Cloxacillin Sodium,Bactopen | Antibacterial , Antibiotic |
Cloxacillin sodium monohydrate (Cloxacillin Sodium) is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. | |||
T4201 | Avibactam sodium | AVE-1330A,NXL-104 | Antibacterial , Antibiotic |
Avibactam sodium (NXL-104) is a reversible β-lactamase inhibitor (IC50: 8/80/38 nM, for TEM-1/P99/KPC-2 β-lactamases). | |||
T5570 | Cephalothin | Cephalotin acid | Antibacterial , Antibiotic |
Cephalothin is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC (Ki: 0.32 μM). | |||
T1312 | Nafcillin sodium monohydrate | CL 8491,nafcillin sodium | Antibacterial , Antibiotic |
Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Pe... | |||
T1631 | Sulbactam | CP45899 | Antibacterial , Antibiotic |
Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol... | |||
T5446 | CIBACRON BLUE 3G-A | Others | |
Cibacron Blue 3G-A, an anthraquinone dye, inhibits R46β-lactamase (Ki: 1.2 uM). | |||
T15047 | Dacisteine | N,S-Diacetyl-L-cysteine | Others |
Dacisteine (N,S-Diacetyl-L-cysteine) is an inhibitor of New Delhi metallo-beta-lactamase-1 (NDM-1, IC50 = 1000 μM). | |||
T14081 | Enmetazobactam | AAI101 | Antibacterial |
Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor for the treatment of multi-drug resistant gram-negative bacterial infections. | |||
T17210 | Vaborbactam | RPX7009 | Antibacterial |
Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections. | |||
T32008 | GSK299423 | GSK-299423,GSK 299423 | |
GSK299423 (GlaxoSmithKline 299423) is an antibiotic that may have therapeutic effect in patients infected with bacteria expressing New Delhi metal-β-lactamase. Antibiotics inhibit the topoisomerases that the bacteria nee... | |||
T60454 | NDM-1 inhibitor-3 | Others | |
NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance. | |||
T17210L1 | (3R,6R)-Vaborbactam | (3R,6R)-RPX7009,(3R,6R)-Vaborbactam (Iso-1360457-46-0) | Antibacterial |
(3R,6R)-Vaborbactam ((3R,6R)-Vaborbactam (Iso-1360457-46-0)) is a cyclic boronic acid pharmacophore β-lactamase inhibitor with potential antimicrobial activity. (S)-Vamicamide ((S)-Vamicamide (Iso-132373-81-0)) is a nove... | |||
T0234 | Methicillin sodium salt | Methicillin sodium,Meticillin sodium | Antibacterial , Antibiotic |
Methicillin sodium salt is the sodium salt form of methicillin, a semisynthetic beta-lactam penicillin antibiotic with beta-lactamase resistant activity. | |||
T13038 | Sultamicillin | Antibacterial , Antibiotic | |
Sultamicillin is an orally active double prodrug of Ampicillin/Sulbactan. Sulbactam is a semisynthetic β-Lactamase inhibitor. | |||
T1143 | Carbenicillin disodium | BRL-2064,Sodium carbenicillin | Cell wall , Antibacterial , Antibiotic |
Carbenicillin disodium (BRL-2064) is a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. | |||
T6685 | Sulbactam sodium | CP-45899-2 | Antibacterial , Antibiotic |
Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor. | |||
T1405 | Cefditoren pivoxil | ME 1207,Cefditoren pivaloyloxymethyl ester,Cefditoren pivoxyl | Antibacterial , Antibiotic |
Cefditoren pivoxil (ME 1207) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. | |||
T13395L | Zidebactam | WCK-5107 | Antibacterial |
Zidebactam (WCK-5107) is an effective β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 inhibitor (IC50: 0.26 μg/mL). | |||
T6268 | Ceftiofur hydrochloride | Ceftiofur HCl,U-67279A,Excenel hydrochloride | Antibacterial , Antibiotic |
Ceftiofur hydrochloride (U-67279A) is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. | |||
T23858 | WCK-5153 | WCK 5153,WCK5153 | Antibacterial |
WCK-5153 is an enhancer of β-Lactamase and an inhibitor of PBP2 with antimicrobial activities against Pseudomonas aeruginosa. WCK-5153 can be used in studies about the treatment of serious infections caused by highly dru... | |||
T0868 | Cefepime Dihydrochloride Monohydrate | Cefepime HCl | Antibacterial , Antibiotic , Antifection |
Cefepime Dihydrochloride Monohydrate (Cefepime HCl) is the hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad... | |||
T60050 | ANT3310 | Antibacterial | |
ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection. | |||
T17210L | Vaborbactam ammonium salt | RPX7009 ammonium salt,Vaborbactam ammonium salt(1360457-46-0 Free base) | Antibacterial |
Vaborbactam ammonium salt is a β-lactamase inhibitor that restores carbapenem activity against KPC-producing strains and is often used in conjunction with other drugs to study fungal infections. | |||
T12166 | Nacubactam | OP0595 free acid | Antibacterial |
Nacubactam (OP0595 free acid) is a potent inhibitor of non-β-lactam-β-lactamase with activity against class A and class C β-lactamases. | |||
T23801 | WCK-4234 sodium | WCK-4234,WCK4234,WCK 4234 | Antibacterial |
WCK-4234 sodium (WCK 4234) is an inhibitor of β-lactamase can be used in studies targeting MDR infections. WCK-4234 sodium inhibits class A, C, and D β-lactamases and OXA carbapenemases. | |||
T13077 | Taniborbactam dihydrochloride | VNRX-5133 dihydrochloride,Taniborbactam 2HCl | Antibacterial , Antifungal |
Taniborbactam dihydrochloride (VNRX-5133 dihydrochloride) is a selective and potent novel cyclic boronic acid β-lactamase inhibitor with antimicrobial activity and significant inhibition of Gram-negative bacteria.Tanibor... | |||
T68137 | Sanfetrinem | GV104326 | Antibiotic |
Sanfetrinem (GV104326) sodium is a novel orally available β-lactamase antibiotic that shows significant antibacterial activity against Gram-positive and Gram-negative bacteria and can be used in the study of bacterial in... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8261 | Ceftazidime Pentahydrate | Antibacterial , Antibiotic | |
Ceftazidime is a β-lactam antibacterial agent which has demonstrated a broad spectrum of activity against Gram-positive and Gram-negative aerobic bacteria. | |||
T15638 | K-252c | PKC | |
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00588 | Beta-lactamase Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. | |||
TMPH-03165 | Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
TMPH-03164 | Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Hydrolyzes both carbenicillin and oxacillin. | |||
TMPH-00584 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins. | |||
TMPH-00585 | Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (Yeast, His) | E. coli | Yeast |
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins. | |||
TMPH-03474 | Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant | Salmonella typhimurium | E. coli |
Has cefotaxime-hydrolyzing activity. | |||
TMPH-00586 | Beta-lactamase TEM Protein, E. coli, Recombinant (His) | E. coli | Yeast |
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4... | |||
TMPH-00587 | Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4... | |||
TMPJ-01157 | LACTB2 Protein, Human, Recombinant (GST) | Human | E. coli |
β-Lactamase-like Protein 2 (LACTB2) is a number of the metallo-beta-lactamase superfamily.LACTB2 also belongs to the Glyoxalase II family. LACTB2 is 288 amino acids long with 8 zinc-binding domains. The LACTB2 gene is ex... | |||
TMPH-03602 | BLIP Protein, S. clavuligerus, Recombinant (His & SUMO) | Streptomyces clavuligerus | E. coli |
BLIP Protein, S. clavuligerus, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-00019 | BlaNDM-1 Protein, Acinetobacter baumannii, Recombinant (His & SUMO) | Acinetobacter baumannii | E. coli |
TMPH-02373 | Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) | Klebsiella pneumoniae | E. coli |
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinol... | |||
TMPH-03488 | Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) | Serratia marcescens | E. coli |
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. | |||
TMPY-02288 | Glyoxalase II/HAGH Protein, Human, Recombinant (His) | Human | E. coli |
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase an... | |||
TMPH-02998 | Porin MspA Protein, Mycobacterium smegmatis, Recombinant (His) | Mycobacterium smegmatis | E. coli |
The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Pl... | |||
TMPY-02447 | Shiga toxin II subunit B Protein, E. coli, Recombinant (His) | E. coli | E. coli |
E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic grou... |