piperazine

Piperazine (1,4-Diazacyclohexane), a gamma-aminobutyric acid (GABA) agonist, serves as a crucial building block and core component in a wide range of marketed drugs known for their varied pharmacological activities.

N-[2-nitro-4-(trifluoromethyl)phenyl]piperazine is a biologically active compound belonging to the piperazine group. It is an important synthetic intermediate used in the preparation of a wide range of drugs, agrochemicals and other chemicals. It is considered an inhibitor of certain enzymes involved in drug metabolism, such as cytochrome P450 enzymes, and has also been shown to have anti-inflammatory and antitumor effects.

1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride (1-PPZ-DHC) is a compound used as a molecular structural unit. It is an analog of the natural product piperazine and has a wide range of biological activities, including anti-inflammatory, anti-tumor and antibacterial activities. It has also been studied for the treatment of neurological disorders such as Alzheimer's and Parkinson's.

Sultosilic acid piperazine salt (A-585) is a novel lipid-lowering compound that can be used to study type IIb familial combined hyperlipidemia.

Piperazine,1-(4-fluorophenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]- is a piperazine derivative with anti-SARS-CoV-2 activity.

1-[(5-methylisoxazol-3-yl)methyl]piperazine (Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]-) is a P2Y12 inhibitor.

1-(1-phenyltetrazol-5-yl)piperazine;hydrochloride (1-(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)piperazine hydrochloride) is a chemical derivative of piperazine that has been used as a starting material for the synthesis of other compounds, such as anti-inflammatory agents. It modulates the activity of enzymes and proteins by binding to their active sites, and has been used in studies of enzyme inhibition and protein structure, as well as in drug metabolism.

1-(3-chloropyridin-2-yl)piperazine dihydrochloride is a piperazine analog often used as a reagent in organic synthesis, as a ligand in coordination chemistry, and as a drug in pharmaceuticals. It is an inhibitor of DPP4, and DPP4 inhibition has been shown to have beneficial effects in the treatment of certain diseases such as type 2 diabetes and obesity.

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitor that inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride contains the target protein PD-1/PD-L1 ligand and PROTAC linker.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used to synthesize PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used to synthesize PROTAC PD-1/PD-L1 degrader-1. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride has anticancer activity. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used as a diluent for the preparation of tablets for direct compression.

GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.

Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.

4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate. It is released into the blood and cerebrospinal fluid and has been used as a biochemical index of recent sympathetic nervous system activity.

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine ((4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone) is a raw material for biosynthesis and can be used to synthesize a wide variety of compounds.

Piperazine adipate is a potent broad spectrum anthelmintic.

1-(2,3-Dichlorphenyl)-piperazine (DCPP) is a potent DHCR7 inhibitor. DHCR7 is the last enzyme in cholesterol biosynthesis.

1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors.

Piperazine sebacate has anthelminthic activity. it be studie for therapy of trichocephalosis.

Thalidomide-Piperazine-Piperidine is a compound composed of a synthesized E3 ligase ligand-linker conjugate. It combines a cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology.

tert-Butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66074 and the CAS number is 414910-15-9.

Thalidomide-Piperazine 5-fluoride is a compound developed by synthesizing an E3 ligase ligand-linker conjugate. It incorporates a cereblon ligand derived from Thalidomide and utilizes a linker commonly employed in PROTAC technology.

Lenalidomide 5'-piperazine, a cerebellar ligand utilized in PROTAC development, facilitates the binding of an E3 ligand to its terminal piperazine. This connection enables subsequent chemical reactions aimed at generating a protein deactivator, employing a rigid linker [1].

N-(2-Hydroxyethyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T65657 and the CAS number is 103-76-4.

tert-Butyl 4-(6-nitropyridin-2-yl)piperazine-1-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T64578 and the CAS number is 2222404-53-5.

Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Thalidomide with a linker commonly utilized in PROTAC technology.

BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound that contains a PD-1/PD-L1 immune checkpoint ligand and a PROTAC linker. It can be utilized in the synthesis of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits the PD-1/PD-L1 interaction, demonstrating an IC50 value of 39.2 nM.

Triclofenol piperazine helps with the treatment of patients imfected with parasite such as hookworms.

1,4-Bis((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride is a useful organic compound for research related to life sciences and the catalog number is T67082.

1-(4-Bromophenyl)piperazine (hydrochloride) is a useful organic compound for research related to life sciences. The catalog number is T65071 and the CAS number is 68104-62-1.

Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized compound that serves as an E3 ligase ligand-linker conjugate. It combines the cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology.

Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected and hybrids were synthesized via substitution at piperazinyl-N4. The reaction of piperazinyl-NH of ciprofloxacin with selected drugs resulted in pronounced growth inhibition of standard as well as resistant bacterial strains[2]. The parent piperazine 6 was found to exhibit a reasonable activity toward the HeLa and MDA MB 231 tumor cell lines (IC50= 9.2 and 8.4 μΜ, respectively)[3]. Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Piperazine adipate inhibits oxaloacetate reduction by 26% and 55% in A. galli and H. gallinae, resepctively[4].

1-(2-Methoxyethyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T66693 and the CAS number is 13484-40-7.

N-Boc-piperazine is a useful organic compound for research related to life sciences. The catalog number is T66552 and the CAS number is 57260-71-6.

1-(Cyclopropylcarbonyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T66810 and the CAS number is 59878-57-8.

1-(2-Chlorophenyl)piperazine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65963 and the CAS number is 41202-32-8.

Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).

Phenyl-glutarimide 4'-piperazine, a piperazine-functionalized cereblon ligand, facilitates the development of PG-PROTACs with enhanced hydrolytic stability and potency compared to those produced with IMiD (immunomodulatory imide drug) analogs. It serves as a foundation for PROTACDegrader development.

1-(4-Methoxyphenyl)-4-(4-nitrophenyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T65608 and the CAS number is 74852-61-2.

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T65582 and the CAS number is 74853-08-0.

Thalidomide-piperazine-Boc is an intermediate utilized for synthesizing BCL6 PROTAC, which targets B-cell lymphoma 6 protein.

tert-Butyl 4-(4-nitropyridin-2-yl)piperazine-1-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T64453 and the CAS number is 1430196-98-7.

1-(4-Methoxybenzyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T67044 and the CAS number is 21867-69-6.

1-(2,4-Difluorophenyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T65059 and the CAS number is 115761-79-0.

Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines the Thalidomide-based cereblon ligand with a linker commonly used in PROTAC technology, serving as an E3 ligase recruiter.

Piperazine citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmintic.

Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].

1,4-Bis(4-nitrophenyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T64560 and the CAS number is 16264-05-4.

1-(2-Pyridyl)piperazine (NSC-13778) is a selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metabolite of Azaperone.

tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66509 and the CAS number is 170911-92-9.

Thalidomide-piperazine hydrochloride is a chemical compound with potential applications in the research of leprosy and multiple myeloma. It serves as a valuable tool in developmental biology, facilitating significant discoveries in the biochemical pathways of limb development [1].

Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimulant effect on respiration. It stimulates the myocardium & central nervous system, decreases peripheral resistance & venous pressure & causes diuresis. The mechanism of action is still not clear, inhibition of phosphodiesterase with a resulting increase in intracellular cyclic AMP does occur, but not apparently at concentrations normally used for clinical effect. Other proposed mechanisms of action include adenosine receptor antagonism, prostaglandin antagonism & effects on intracellular......

DMI-9523 is nuclear factor NF-κB activation inhibitor. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. DA-DKP can modul

Aspartyl-alanyl-diketopiperazine (DA-DKP) is a known immunomodulatory molecule from the N terminus of human albumin.