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DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.
Cat. No. Product name CAS No. Purity Chemical Structure
T16287 Neurodazine 937807-66-4 98%
Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
T8967 SW155246 420092-79-1 98%
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF...
T15081 DC_517 500017-70-9 98%
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
T10840 CM-579 trihydrochloride (1846570-40-8 free base) T10840 98%
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
T12790 Guadecitabine sodium 929904-85-8 98%
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
T19383 Isomaltotriose 3371-50-4 98%
Isomaltotriose is a sugar from enzymic hydrolyzates of the dextran from Leuconostoc mesenteroides NRRL B-512.
T11469 GSK-3484862 2170136-65-7 98%
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
T24871 TFMB-(S)-2-HG 1445703-64-9 98%
TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the po...
T9573 GSK3685032 2170137-61-6 98%
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DN...
T10840L CM-579 1846570-40-8 98%
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T13954 UNC6852 2688842-08-0 98%
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
T3089 6-Thioguanine 154-42-7 100%
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T5198 Bobcat339 2280037-51-4 98%
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
T7194 CM-272 1846570-31-7 98.21%
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T9681 MAK-683 hyrochloride 2170606-94-5 98.87%
MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED) (patent US20160176882 A1, compound example 2). MAK683 exhibits IC50s of 59, 26, 89 n...
T2169 Zebularine 3690-10-6 99.04%
Zebularine is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. ...
T1904 SGI-1027 1020149-73-8 99.45%
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
T0018 Procainamide hydrochloride 614-39-1 99.46%
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine...
T26972 Cedazuridine 1141397-80-9 99.46%
Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
T7840 2',3',5'-triacetyl-5-Azacytidine 10302-78-0 99.48%
2',3',5'-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
Neurodazine
T16287
Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
SW155246
T8967
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF...
DC_517
T15081
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
CM-579 trihydrochloride (1846570-40-8 free base)
T10840
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
Guadecitabine sodium
T12790
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
Isomaltotriose
T19383
Isomaltotriose is a sugar from enzymic hydrolyzates of the dextran from Leuconostoc mesenteroides NRRL B-512.
GSK-3484862
T11469
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
TFMB-(S)-2-HG
T24871
TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the po...
GSK3685032
T9573
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DN...
CM-579
T10840L
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
UNC6852
T13954
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
6-Thioguanine
T3089
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Bobcat339
T5198
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
CM-272
T7194
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
MAK-683 hyrochloride
T9681
MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED) (patent US20160176882 A1, compound example 2). MAK683 exhibits IC50s of 59, 26, 89 n...
Zebularine
T2169
Zebularine is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. ...
SGI-1027
T1904
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
Procainamide hydrochloride
T0018
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine...
Cedazuridine
T26972
Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
2',3',5'-triacetyl-5-Azacytidine
T7840
2',3',5'-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
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