DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.

Cat. No.	Product name	CAS No.	Purity
T16287	Neurodazine	937807-66-4	98%
T16287	Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
T8967	SW155246	420092-79-1	98%
T8967	SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF...
T15081	DC_517	500017-70-9	98%
T15081	DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
T10840	CM-579 trihydrochloride (1846570-40-8 free base)	T10840	98%
T10840	CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
T12790	Guadecitabine sodium	929904-85-8	98%
T12790	Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
T19383	Isomaltotriose	3371-50-4	98%
T19383	Isomaltotriose is a sugar from enzymic hydrolyzates of the dextran from Leuconostoc mesenteroides NRRL B-512.
T11469	GSK-3484862	2170136-65-7	98%
T11469	GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
T24871	TFMB-(S)-2-HG	1445703-64-9	98%
T24871	TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the po...
T9573	GSK3685032	2170137-61-6	98%
T9573	GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DN...
T10840L	CM-579	1846570-40-8	98%
T10840L	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T13954	UNC6852	2688842-08-0	98%
T13954	UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
T3089	6-Thioguanine	154-42-7	100%
T3089	Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T5198	Bobcat339	2280037-51-4	98%
T5198	Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
T7194	CM-272	1846570-31-7	98.21%
T7194	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T9681	MAK-683 hyrochloride	2170606-94-5	98.87%
T9681	MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED) (patent US20160176882 A1, compound example 2). MAK683 exhibits IC50s of 59, 26, 89 n...
T2169	Zebularine	3690-10-6	99.04%
T2169	Zebularine is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. ...
T1904	SGI-1027	1020149-73-8	99.45%
T1904	SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
T0018	Procainamide hydrochloride	614-39-1	99.46%
T0018	Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine...
T26972	Cedazuridine	1141397-80-9	99.46%
T26972	Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
T7840	2',3',5'-triacetyl-5-Azacytidine	10302-78-0	99.48%
T7840	2',3',5'-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.