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DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.
Cat. No. Product name CAS No. Purity Chemical Structure
T16269 Nanaomycin A 52934-83-5 98%
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
T12790 Guadecitabine sodium 929904-85-8 98%
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
T17059 Tetrahydrouridine 18771-50-1 98%
Tetrahydrouridine is a competitive cytidine deaminase inhibitor and multidrug resistance modulator. It makes tumor cells more sensitive to radiation therapy maki...
T19383 Isomaltotriose 3371-50-4 98%
Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.
T16287 Neurodazine 937807-66-4 98%
Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
T10840 CM-579 trihydrochloride (1846570-40-8 free base) T10840 98%
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
T15081 DC_517 500017-70-9 98%
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
T15080 DC-05 890643-16-0 98%
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
T0192 Levetiracetam 102767-28-2 98%
Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Leveti...
T1339 5-Azacytidine 320-67-2 98%
Azacitidine, a pyrimidine nucleoside analogue of cytidine, blocks DNA methylation with antineoplastic activity.
T3717 Hinokitiol 499-44-5 98%
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...
T2038 RG108 48208-26-0 98%
RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
T7457 5-Methyl-2'-deoxycytidine 838-07-3 98%
5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.
T10840L CM-579 1846570-40-8 98%
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T2495 Lomeguatrib 192441-08-0 98%
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T7718 5-Fluoro-2'-deoxycytidine 10356-76-0 98%
2'-DEOXY-5-FLUOROCYTIDINE is an inhibitor of DNA methyltransferase (DNMT) .
T26972 Cedazuridine 1141397-80-9 98%
Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
T1904 SGI-1027 1020149-73-8 98%
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
T1508 Decitabine 2353-33-5 98%
Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
T24871 TFMB-(S)-2-HG 1445703-64-9 98%
TFMB-(S)-2-HG is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases. W...
Nanaomycin A
T16269
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
Guadecitabine sodium
T12790
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
Tetrahydrouridine
T17059
Tetrahydrouridine is a competitive cytidine deaminase inhibitor and multidrug resistance modulator. It makes tumor cells more sensitive to radiation therapy maki...
Isomaltotriose
T19383
Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.
Neurodazine
T16287
Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
CM-579 trihydrochloride (1846570-40-8 free base)
T10840
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
DC_517
T15081
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
DC-05
T15080
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
Levetiracetam
T0192
Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Leveti...
5-Azacytidine
T1339
Azacitidine, a pyrimidine nucleoside analogue of cytidine, blocks DNA methylation with antineoplastic activity.
Hinokitiol
T3717
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...
RG108
T2038
RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
5-Methyl-2'-deoxycytidine
T7457
5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.
CM-579
T10840L
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
Lomeguatrib
T2495
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
5-Fluoro-2'-deoxycytidine
T7718
2'-DEOXY-5-FLUOROCYTIDINE is an inhibitor of DNA methyltransferase (DNMT) .
Cedazuridine
T26972
Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
SGI-1027
T1904
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
Decitabine
T1508
Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
TFMB-(S)-2-HG
T24871
TFMB-(S)-2-HG is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases. W...
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