T16269 |
Nanaomycin A
|
52934-83-5
|
98%
|
|
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
|
T12790 |
Guadecitabine sodium
|
929904-85-8
|
98%
|
|
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
|
T17059 |
Tetrahydrouridine
|
18771-50-1
|
98%
|
|
Tetrahydrouridine is a competitive cytidine deaminase inhibitor and multidrug resistance modulator. It makes tumor cells more sensitive to radiation therapy maki...
|
T19383 |
Isomaltotriose
|
3371-50-4
|
98%
|
|
Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.
|
T16287 |
Neurodazine
|
937807-66-4
|
98%
|
|
Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
|
T10840 |
CM-579 trihydrochloride (1846570-40-8 free base)
|
T10840
|
98%
|
|
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
|
T15081 |
DC_517
|
500017-70-9
|
98%
|
|
DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
|
T15080 |
DC-05
|
890643-16-0
|
98%
|
|
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
|
T0192 |
Levetiracetam
|
102767-28-2
|
98%
|
|
Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Leveti...
|
T1339 |
5-Azacytidine
|
320-67-2
|
98%
|
|
Azacitidine, a pyrimidine nucleoside analogue of cytidine, blocks DNA methylation with antineoplastic activity.
|
T3717 |
Hinokitiol
|
499-44-5
|
98%
|
|
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...
|
T2038 |
RG108
|
48208-26-0
|
98%
|
|
RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
|
T7457 |
5-Methyl-2'-deoxycytidine
|
838-07-3
|
98%
|
|
5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.
|
T10840L |
CM-579
|
1846570-40-8
|
98%
|
|
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
|
T2495 |
Lomeguatrib
|
192441-08-0
|
98%
|
|
Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
|
T7718 |
5-Fluoro-2'-deoxycytidine
|
10356-76-0
|
98%
|
|
2'-DEOXY-5-FLUOROCYTIDINE is an inhibitor of DNA methyltransferase (DNMT) .
|
T26972 |
Cedazuridine
|
1141397-80-9
|
98%
|
|
Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
|
T1904 |
SGI-1027
|
1020149-73-8
|
98%
|
|
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
|
T1508 |
Decitabine
|
2353-33-5
|
98%
|
|
Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
|
T24871 |
TFMB-(S)-2-HG
|
1445703-64-9
|
98%
|
|
TFMB-(S)-2-HG is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases. W...
|