DNA Methyltransferase

DNA methyltransferases are a group of enzymes involved in the regulation of gene expression. DNA methyltransferases cause the aberrant DNA methylation of tumor suppressor genes, which become hypermethylated and transcriptionally silent in some blood cancers.

Cat. No.	Product name	CAS No.	Purity
T16269	Nanaomycin A	52934-83-5	98%
T16269	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 5...
T12790	Guadecitabine sodium	929904-85-8	98%
T12790	Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
T17059	Tetrahydrouridine	18771-50-1	98%
T17059	Tetrahydrouridine is a competitive cytidine deaminase inhibitor and multidrug resistance modulator. It makes tumor cells more sensitive to radiation therapy maki...
T19383	Isomaltotriose	3371-50-4	98%
T19383	Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.
T16287	Neurodazine	937807-66-4	98%
T16287	Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differenti...
T10840	CM-579 trihydrochloride (1846570-40-8 free base)	T10840	98%
T10840	CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide ...
T15081	DC_517	500017-70-9	98%
T15081	DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).
T15080	DC-05	890643-16-0	98%
T15080	DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
T0192	Levetiracetam	102767-28-2	98%
T0192	Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Leveti...
T1339	5-Azacytidine	320-67-2	98%
T1339	Azacitidine, a pyrimidine nucleoside analogue of cytidine, blocks DNA methylation with antineoplastic activity.
T3717	Hinokitiol	499-44-5	98%
T3717	β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...
T2038	RG108	48208-26-0	98%
T2038	RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
T7457	5-Methyl-2'-deoxycytidine	838-07-3	98%
T7457	5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.
T10840L	CM-579	1846570-40-8	98%
T10840L	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T2495	Lomeguatrib	192441-08-0	98%
T2495	Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T7718	5-Fluoro-2'-deoxycytidine	10356-76-0	98%
T7718	2'-DEOXY-5-FLUOROCYTIDINE is an inhibitor of DNA methyltransferase (DNMT) .
T26972	Cedazuridine	1141397-80-9	98%
T26972	Cedazuridine is an oral inhibitor of cytidine deaminase with antineoplastic properties.
T1904	SGI-1027	1020149-73-8	98%
T1904	SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respec...
T1508	Decitabine	2353-33-5	98%
T1508	Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication.
T24871	TFMB-(S)-2-HG	1445703-64-9	98%
T24871	TFMB-(S)-2-HG is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases. W...