FLT

The fms-like tyrosine kinase (Fit) is a transmembrane receptor in the tyrosine kinase family. Expression of fit complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF).

Cat. No.	Product name	CAS No.	Purity
T2653	SB1317	1204918-72-8	98%
T2653	SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
T10592	BPR1K871	2443767-35-7	98%
T10592	BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC 50 s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development ...
T6193	Dovitinib Dilactic Acid	852433-84-2	98%
T6193	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T12610L	3-Hydroxy Midostaurin	179237-49-1	98%
T12610L	3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately...
T16995	TAS05567	1429038-15-2	98%
T16995	TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
T34656	SKLB 1028	1350544-93-2	98%
T34656	SKLB1028 is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. It shows excellent activity in FLT3-driven AML models and considerable potency in CM...
T11731	JTV-519 free base	145903-06-6	98%
T11731	JTV-519 free base (K201 free base),Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (...
T6132	ENMD-2076 Tartrate	1291074-87-7	98%
T6132	ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more select...
T9428	HM43239	2294874-49-8	98%
T9428	HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D...
T6515	Go6976	136194-77-9	98%
T6515	Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and ...
T11712	Jasplakinolide	102396-24-7	98%
T11712	Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, ha...
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T21503	(E/Z)-Zotiraciclib	937270-47-8	98%
T21503	(E/Z)-Zotiraciclib inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.
TQ0235	AC710	1351522-04-7	98%
TQ0235	AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
T6129	GSK-1070916	942918-07-2	98%
T6129	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
T38562	AKN-028	1175017-90-9	98%
T38562	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
T8317	5'-Fluoroindirubinoxime	861214-33-7	100%
T8317	5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
T7104	Dovitinib lactate	692737-80-7	100%
T7104	Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
T2605	Fostamatinib Disodium	1025687-58-4	96.13%
T2605	Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.