T14683 |
BMS-983970
|
1584713-87-0
|
98%
|
|
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
|
T4652 |
(+)-Taxifolin
|
17654-26-1
|
98%
|
|
Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.
|
TP1540 |
Jagged-1 (188-204)
|
219127-21-6
|
98%
|
|
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
|
TQ0026 |
MDR-1339
|
1018946-38-7
|
98%
|
|
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
|
T16133 |
MRK-560
|
677772-84-8
|
98%
|
|
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
|
T3633 |
Crenigacestat
|
1421438-81-4
|
97.36%
|
|
LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch rec...
|
T4S1990 |
Carvacrol
|
499-75-2
|
97.52%
|
|
1. 5-Isopropyl-2-methylphenol presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. 5-Isopropyl-2-methylphenol present...
|
T2262 |
Itanapraced
|
749269-83-8
|
98%
|
|
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
|
T13410 |
ZLDI-8
|
667880-38-8
|
98.09%
|
|
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
|
T3399 |
Psoralidin
|
18642-23-4
|
98.75%
|
|
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
|
T6861 |
IMR-1
|
310456-65-6
|
98.76%
|
|
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
|
T6249 |
Avagacestat
|
1146699-66-2
|
98.87%
|
|
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-...
|
T9015 |
LY900009
|
209984-68-9
|
98.97%
|
|
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
|
T1602 |
Valproic acid sodium salt
|
1069-66-5
|
99%
|
|
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
|
T7064 |
Valproic Acid
|
99-66-1
|
99%
|
|
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
|
T4364 |
Aftin-4
|
866893-90-5
|
99.03%
|
|
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 incre...
|
T6125 |
Semagacestat
|
425386-60-3
|
99.11%
|
|
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
|
T2625 |
MK-0752
|
471905-41-6
|
99.19%
|
|
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
|
T6063 |
LY-411575
|
209984-57-6
|
99.38%
|
|
LY411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39...
|
T11358 |
Gamma-secretase modulator 1
|
1172637-87-4
|
99.48%
|
|
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
|