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Gamma-secretase

Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43[verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch, ErbB4, E-cadherin, N-cadherin, ephrin-B2, or CD44.
Cat. No. Product name CAS No. Purity Chemical Structure
TP1540 Jagged-1 (188-204) 219127-21-6 98%
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
T4652 (+)-Taxifolin 17654-26-1 98%
Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.
T14683 BMS-983970 1584713-87-0 98%
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
T71534L CIA-1 (Free base) 452087-38-6 98%
CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhib...
T16133 MRK-560 677772-84-8 98%
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
T10532 BI-1408 2231075-94-6 98%
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
TQ0026 MDR-1339 1018946-38-7 98%
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
T63208 Aβ-IN-1 2766509-32-2 98%
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
T14673 BMS 299897 290315-45-6 98%
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
T21890 JLK6 62252-26-0 98%
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
T31987 Gossypolone 4547-72-2 98%
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
T4S1990 Carvacrol 499-75-2 98%
1. 5-Isopropyl-2-methylphenol presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. 5-Isopropyl-2-methylphenol present...
T13410 ZLDI-8 667880-38-8 98%
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T3399 Psoralidin 18642-23-4 98%
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
T6861 IMR-1 310456-65-6 98%
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T3633 Crenigacestat 1421438-81-4 98%
LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch rec...
T9015 LY900009 209984-68-9 98%
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
T1602 Valproic acid sodium salt 1069-66-5 98%
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
T4364 Aftin-4 866893-90-5 98%
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 incre...
T3540 IMR-1A 331862-41-0 98%
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Jagged-1 (188-204)
TP1540
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
(+)-Taxifolin
T4652
Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.
BMS-983970
T14683
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
CIA-1 (Free base)
T71534L
CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhib...
MRK-560
T16133
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
BI-1408
T10532
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
MDR-1339
TQ0026
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
Aβ-IN-1
T63208
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
BMS 299897
T14673
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
JLK6
T21890
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
Gossypolone
T31987
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
Carvacrol
T4S1990
1. 5-Isopropyl-2-methylphenol presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. 5-Isopropyl-2-methylphenol present...
ZLDI-8
T13410
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
Psoralidin
T3399
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
IMR-1
T6861
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Crenigacestat
T3633
LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch rec...
LY900009
T9015
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
Valproic acid sodium salt
T1602
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
Aftin-4
T4364
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 incre...
IMR-1A
T3540
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
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