TP1540 |
Jagged-1 (188-204)
|
219127-21-6
|
98%
|
|
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
|
T4652 |
(+)-Taxifolin
|
17654-26-1
|
98%
|
|
Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.
|
T14683 |
BMS-983970
|
1584713-87-0
|
98%
|
|
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
|
T71534L |
CIA-1 (Free base)
|
452087-38-6
|
98%
|
|
CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhib...
|
T16133 |
MRK-560
|
677772-84-8
|
98%
|
|
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
|
T10532 |
BI-1408
|
2231075-94-6
|
98%
|
|
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
|
TQ0026 |
MDR-1339
|
1018946-38-7
|
98%
|
|
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
|
T63208 |
Aβ-IN-1
|
2766509-32-2
|
98%
|
|
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
|
T14673 |
BMS 299897
|
290315-45-6
|
98%
|
|
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
|
T21890 |
JLK6
|
62252-26-0
|
98%
|
|
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
|
T31987 |
Gossypolone
|
4547-72-2
|
98%
|
|
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
|
T4S1990 |
Carvacrol
|
499-75-2
|
98%
|
|
1. 5-Isopropyl-2-methylphenol presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. 5-Isopropyl-2-methylphenol present...
|
T13410 |
ZLDI-8
|
667880-38-8
|
98%
|
|
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
|
T3399 |
Psoralidin
|
18642-23-4
|
98%
|
|
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
|
T6861 |
IMR-1
|
310456-65-6
|
98%
|
|
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
|
T3633 |
Crenigacestat
|
1421438-81-4
|
98%
|
|
LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch rec...
|
T9015 |
LY900009
|
209984-68-9
|
98%
|
|
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
|
T1602 |
Valproic acid sodium salt
|
1069-66-5
|
98%
|
|
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
|
T4364 |
Aftin-4
|
866893-90-5
|
98%
|
|
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 incre...
|
T3540 |
IMR-1A
|
331862-41-0
|
98%
|
|
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
|