Gamma-secretase

Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43[verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch, ErbB4, E-cadherin, N-cadherin, ephrin-B2, or CD44.

Cat. No.	Product name	CAS No.	Purity
TP1540	Jagged-1 （188-204）	219127-21-6	98%
TP1540	This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
T4652	(+)-Taxifolin	17654-26-1	98%
T4652	Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.
T14683	BMS-983970	1584713-87-0	98%
T14683	BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
T71534L	CIA-1 (Free base)	452087-38-6	98%
T71534L	CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhib...
T16133	MRK-560	677772-84-8	98%
T16133	MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
T10532	BI-1408	2231075-94-6	98%
T10532	BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
TQ0026	MDR-1339	1018946-38-7	98%
TQ0026	MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
T63208	Aβ-IN-1	2766509-32-2	98%
T63208	Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
T14673	BMS 299897	290315-45-6	98%
T14673	BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
T21890	JLK6	62252-26-0	98%
T21890	JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
T31987	Gossypolone	4547-72-2	98%
T31987	Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
T4S1990	Carvacrol	499-75-2	98%
T4S1990	1. 5-Isopropyl-2-methylphenol presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. 5-Isopropyl-2-methylphenol present...
T13410	ZLDI-8	667880-38-8	98%
T13410	ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T3399	Psoralidin	18642-23-4	98%
T3399	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
T6861	IMR-1	310456-65-6	98%
T6861	IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T3633	Crenigacestat	1421438-81-4	98%
T3633	LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch rec...
T9015	LY900009	209984-68-9	98%
T9015	LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
T1602	Valproic acid sodium salt	1069-66-5	98%
T1602	Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
T4364	Aftin-4	866893-90-5	98%
T4364	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 incre...
T3540	IMR-1A	331862-41-0	98%
T3540	IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.