Gamma-secretase

Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43[verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch, ErbB4, E-cadherin, N-cadherin, ephrin-B2, or CD44.

Cat. No.	Product name	CAS No.	Purity
T14683	BMS-983970	1584713-87-0	98%
T14683	BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
T4652	(+)-Taxifolin	17654-26-1	98%
T4652	Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.
TP1540	Jagged-1 （188-204）	219127-21-6	98%
TP1540	This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
TQ0026	MDR-1339	1018946-38-7	98%
TQ0026	MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
T16133	MRK-560	677772-84-8	98%
T16133	MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
T3633	Crenigacestat	1421438-81-4	97.36%
T3633	LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch rec...
T4S1990	Carvacrol	499-75-2	97.52%
T4S1990	1. 5-Isopropyl-2-methylphenol presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. 5-Isopropyl-2-methylphenol present...
T2262	Itanapraced	749269-83-8	98%
T2262	CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T13410	ZLDI-8	667880-38-8	98.09%
T13410	ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T3399	Psoralidin	18642-23-4	98.75%
T3399	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
T6861	IMR-1	310456-65-6	98.76%
T6861	IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T6249	Avagacestat	1146699-66-2	98.87%
T6249	Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-...
T9015	LY900009	209984-68-9	98.97%
T9015	LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
T1602	Valproic acid sodium salt	1069-66-5	99%
T1602	Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
T7064	Valproic Acid	99-66-1	99%
T7064	Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
T4364	Aftin-4	866893-90-5	99.03%
T4364	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 incre...
T6125	Semagacestat	425386-60-3	99.11%
T6125	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T2625	MK-0752	471905-41-6	99.19%
T2625	MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T6063	LY-411575	209984-57-6	99.38%
T6063	LY411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39...
T11358	Gamma-secretase modulator 1	1172637-87-4	99.48%
T11358	gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.