T2610 |
BMS-599626
|
714971-09-2
|
98.79%
|
|
BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
|
T14677 |
BMS-690514
|
859853-30-8
|
98%
|
|
BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
|
T6827 |
Endoxifen Z-isomer hydrochloride
|
1032008-74-4
|
98%
|
|
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
|
T11213L |
Epertinib
|
908305-13-5
|
98%
|
|
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
|
TP1583L |
HER2/neu (654-662) GP2 acetate
|
TP1583L
|
98%
|
|
HER2/neu (654-662) GP2 acetate is derived from the human epidermal growth factor receptor 2 (HER2-Neu, 654–662). HER2/neu (654-662) GP2 acetate induces HLA-A2-re...
|
T0801 |
Tannic acid
|
1401-55-4
|
AR
|
|
Tannic acid (Gallotannic acid) is a novel hERG channel blocker.
|
T2303 |
(S)-Afatinib
|
439081-18-2
|
99.96%
|
|
(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, r...
|
T2364 |
Tucatinib
|
937263-43-9
|
99.96%
|
|
Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
|
T5398 |
BMS 599626 2HCl (873837-23-1(HCl))
|
T5398
|
99.94%
|
|
BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100-...
|
TN1092 |
O-Nornuciferine
|
3153-55-7
|
99.86%
|
|
O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
|
T8182 |
Guanfu base A
|
1394-48-5
|
99.85%
|
|
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
|
T2280 |
Endoxifen (Z-isomer)
|
112093-28-4
|
99.81%
|
|
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
|
T9009 |
ICA-105574
|
316146-57-3
|
99.77%
|
|
ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action poten...
|
T12542 |
Rilzabrutinib
|
1575596-29-0
|
99.76%
|
|
Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
|
TQ0139 |
VU 0240551
|
893990-34-6
|
99.72%
|
|
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
|
T6719 |
Varlitinib
|
845272-21-1
|
99.7%
|
|
Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.
|
T9304 |
(S)-Sunvozertinib
|
2370013-49-1
|
99.69%
|
|
(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
|
T1773 |
Afatinib Dimaleate
|
850140-73-7
|
99.66%
|
|
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth f...
|
T67385 |
Neratinib maleate
|
915942-22-2
|
99.64%
|
|
Neratinib maleate (HKI-272 maleate) is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respec...
|
T3554 |
RG14620
|
136831-49-7
|
99.56%
|
|
RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.
|