HER

The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.

Cat. No.	Product name	CAS No.	Purity
TP1583L	HER2/neu (654-662) GP2 acetate	TP1583L	98%
TP1583L	HER2/neu (654-662) GP2 acetate is derived from the human epidermal growth factor receptor 2 (HER2-Neu, 654–662). HER2/neu (654-662) GP2 acetate induces HLA-A2-re...
T69534	Zongertinib	2728667-27-2	98%
T69534	Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (TKD...
T5390	BMS-599626 Hydrochloride	873837-23-1	98%
T5390	BMS-599626 Hydrochloride is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential a...
T67385	Neratinib maleate	915942-22-2	98%
T67385	Neratinib maleate is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respectively.Neratinib m...
T2610L	BMS-599626 2HCL(714971-09-2 Free base)	1781932-33-9	98%
T2610L	BMS-599626 2HCL is a BMS-599626 derivative.BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respective...
T16444	PD-118057	313674-97-4	98%
T16444	PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membran...
T2610	BMS-599626	714971-09-2	98%
T2610	BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T8182	Guanfu base A	1394-48-5	98%
T8182	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T14677	BMS-690514	859853-30-8	98%
T14677	BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
T6827	Endoxifen Z-isomer hydrochloride	1032008-74-4	98%
T6827	Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T11213L	Epertinib	908305-13-5	98%
T11213L	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
T10531	BGB-102	807640-87-5	98%
T10531	BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
T0801	Tannic acid	1401-55-4	98%
T0801	Tannic acid is a novel hERG channel blocker.
T2303	(S)-Afatinib	439081-18-2	98%
T2303	Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, resp...
T2364	Tucatinib	937263-43-9	98%
T2364	Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
T5398	BMS 599626 2HCl (873837-23-1(HCl))	T5398	98%
T5398	BMS-599626 (AC480) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100-fold to Lck, VEGFR2, c-Kit, MET, etc.
TN1092	O-Nornuciferine	3153-55-7	98%
TN1092	O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
T9009	ICA-105574	316146-57-3	98%
T9009	ICA-105574 is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. ...
T12542	Rilzabrutinib	1575596-29-0	98%
T12542	PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
TQ0139	VU 0240551	893990-34-6	98%
TQ0139	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.