T0488 |
Finasteride |
Finasteride is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM. |
T0725 |
Isoliquiritigenin |
Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM). |
T1076 |
DexamethasoneHOT |
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-1...
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T1458 |
Epalrestat |
Epalrestat, an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy ...
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T1499 |
Dutasteride |
Dutasteride is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia. |
T2013 |
Ponalrestat |
Ponalrestat is an aldose reductase inhibitor. |
T3665 |
Tectoridin |
Tectoridin possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflam...
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T3915 |
Ginsenoside Ro |
GinsenosideRo exhibits a Ca2+-antagonistic antiplatelet effect. |
T6S0840 |
Engeletin |
1. Engeletin may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engel...
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T6102 |
2'-acetylacteoside |
2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-A...
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T6S2384 |
Poliumoside |
Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exh...
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T5195 |
Alrestatin |
Alrestatin is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro. |
T4918 |
DL-Glyceraldehyde |
Glyceraldehyde is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When ...
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T5813 |
BYAKANGELICIN |
BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataract...
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TN2295 |
Vicenin -1 |
Vicenin-1 possesses potent anti-inflammatory and anti-oxidant activity. |
T10393 |
AT-007 |
AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and pre...
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T15281 |
Fidarestat |
Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the poten...
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T17114 |
Tolrestat |
Tolrestat is a potent and orally active inhibitor of aldose reductase (IC50: 35 nM). |
TN3287 |
8-Lavandulylkaempferol |
8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, re...
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TN3760 |
Danshenol A |
Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A...
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