Src

Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates. Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail.

Cat. No.	Product name	CAS No.	Purity
T10583	Bosutinib D8	T10583	98%
T10583	Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 nM/1 nM).
T15674	Tirbanibulin dihydrochloride	1038395-65-1	98%
T15674	Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
T13186L	TL02-59 dihydrochloride	2415263-06-6	98%
T13186L	TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM).
T10206	A 419259	364042-47-7	98%
T10206	A 419259 is a pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family (IC50s: 9 nM, <3 nM and <3 nM for Src, Lck and Lyn).
T10784	CH6953755	2055918-71-1	98%
T10784	CH6953755 is a potent, orally active and selective inhibitor of YES1 kinase (IC50: 1.8 nM). It inhibits YES1 kinase, leading to antitumor activity against YES1 G...
T6732	WYE-687	1062161-90-3	98%
T6732	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(...
T14074	A-770041	869748-10-7	98%
T14074	A-770041 is selective and orally active Src-family Lck inhibitor, and the other Src family kinase involved in T-cell signaling. A-770041 is a 147 nM inhibitor of...
TN3139	5α-Hydroxycostic acid	132185-83-2	98%
TN3139	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T6132	ENMD-2076 Tartrate	1291074-87-7	98%
T6132	ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more select...
TQ0132	A 419259 trihydrochloride	1435934-25-0	98%
TQ0132	A 419259 trihydrochloride is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).
T6730	WAY-600	1062159-35-6	98%
T6730	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...
T11752	Keap1-Nrf2-IN-1	2232112-72-8	98%
T11752	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nr...
T2610	BMS-599626	714971-09-2	98%
T2610	BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T22303	Dasatinib hydrochloride	854001-07-3	98%
T22303	Dasatinib hydrochloride is a highly ATP competitive, potent, orally active inhibitor of dual Src/Bcr-Abl(with Ki values of 16 pM and 30 pM for Src and Bcr-Abl, r...
T9723	WAY-303290	323176-64-3	98%
T9723	WAY-303290 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.
T2372L	Ponatinib Hydrochloride	1114544-31-8	98%
T2372L	Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
T13186	TL02-59	1315330-17-6	98%
T13186	TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-5...
T13156L	TG 100572 Hydrochloride	867331-64-4	98%
T13156L	TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
T13000	Src Inhibitor 3	2380027-49-4	98%
T13000	Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferati...