Src

Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates. Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail.

Cat. No.	Product name	CAS No.	Purity
T11745	KB SRC 4	1380088-03-8	99.66%
T11745	KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.
T2610	BMS-599626	714971-09-2	98.73%
T2610	BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T10583	Bosutinib D8	T10583	98%
T10583	Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 nM/1 nM).
T79516	BT424	2755180-37-9	98%
T79516	BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].
T14074	A-770041	869748-10-7	98%
T14074	A-770041 is a selective and orally active inhibitor targeting the Src-family kinase, Lck, which plays a crucial role in T-cell signaling. With an IC50 value of 1...
T11752	Keap1-Nrf2-IN-1	2232112-72-8	98%
T11752	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nr...
T10206	A 419259	364042-47-7	98%
T10206	A 419259 is a pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family (IC50s: 9 nM, <3 nM and <3 nM for Src, Lck and Lyn).
TN3139	5α-Hydroxycostic acid	132185-83-2	98%
TN3139	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T15674	Tirbanibulin dihydrochloride	1038395-65-1	98%
T15674	Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
T14055	5Z-7-Oxozeaenol	253863-19-3	98%
T14055	5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
T13186L	TL02-59 dihydrochloride	2415263-06-6	98%
T13186L	TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM).
T22303	Dasatinib hydrochloride	854001-07-3	99.98%
T22303	Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent ant...
T2696	PRT062607 hydrochloride	1370261-97-4	99.93%
T2696	PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases...
T2609	Masitinib	790299-79-5	99.91%
T2609	Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
T4301	AD80	1384071-99-1	99.9%
T4301	AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
T1448L	Dasatinib monohydrate	863127-77-9	99.89%
T1448L	Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib mon...
T1448	Dasatinib	302962-49-8	99.89%
T1448	Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitum...
T2341	KW-2449	1000669-72-6	99.89%
T2341	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T4071	Repotrectinib	1802220-02-5	99.86%
T4071	Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
T3935	1-Naphthyl PP1	221243-82-9	99.85%
T3935	1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)