eph

Eph inhibitor 2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors.

SI-2 hydrochloride (EPH 116 hydrochloride) is a highly promising inhibitor of SRC-3 SMI: SRC-3 (PPI)(IC50 values of 3-20 nM for breast cancer cell death), with acceptable oral availability.

SI-2 is an inhibitor (SMI) of steroid receptor coactivator-3 (SRC-3 or AIB1). SI-2 can selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells, and selectively induce breast cancer cell death with IC50 values in the low nanomolar range (3-20 nM), but not affect normal cell viability.

Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.

Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production.

(Z)-Butylidenephthalide ((Z)-3-Butylidenephthalide) has antitumor and hypoglycemic effects, and can effectively inhibit the tumor growth of glioma and inhibit R-glucosidase activity.

[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.

3-hydroxycephem is a useful organic compound for research related to life sciences. The catalog number is T4581 and the CAS number is 54639-48-4.

cephalandole B, an indole alkaloid isolated from cyanide, significantly inhibited IL-17A gene expression and suppressed IL-17A luciferase reporter in Jukat cells in a dose-dependent manner.

[Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)

Cephaeline hydrochloride, a phenolic alkaloid found in Indian Ipecac, effectively inhibits the infection of viruses ZIKV and EBOV.

(D-Ser2)-Leu-Enkephalin-Thr is a delta selective agent of opioid receptor and shows analgesic effects.

Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.

4-Hydroxymephenytoin ((+/-)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.

ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor), an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy.

Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumour cells.

Synephrine hydrochloride (Oxedrine hydrochloride) is an agonist that acts on sympathomimetic α-adrenergic receptor (AR).

Cephalexin (Cephacillin) is a cephalosporin antibiotic.

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

Ephedrine levulinate is an alkaloid. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons.

7-Epi-10-deacetylcephalomannine is a natural product from Taxus sumatrana.

D-Epinephrine can be used as a hormone, neurotransmitter, and medication. Epinephrine can be normally obtained from the adrenal glands and certain neurons. It involves in the fight-or-flight response by increasing blood flow to muscles, output of the hear

Sephadex G 50 is a gel filtration medium commonly utilized in gel permeation chromatography for effective fractionation of glycopeptide mixtures.

Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 μg/ml, respectively.References1. Jones, R.N., and Packer, R.R. Cefotaxime, cephalothin, and cephapirin: Antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. Diagn. Microbiol. Infect. Dis. 2(1), 65-68 (1984). Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 μg/ml, respectively. References1. Jones, R.N., and Packer, R.R. Cefotaxime, cephalothin, and cephapirin: Antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. Diagn. Microbiol. Infect. Dis. 2(1), 65-68 (1984).

[D-Ala2] Leu-Enkephalinamide, an enkephalin analog, exhibits significant corneal permeability and analgesic properties, making it suitable for ocular disease research [1] [2].

(Rac)-Tephrosin, a natural product, is isolated from Tephrosia purpurea [1].

Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells when used at a concentration of 4 μM.3 1.Qian-Cutrone, J., Huang, S., Shu, Y.-Z., et al.Stephacidin A and B: Two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cellsJ. Am. Chem. Soc.124(49)14556-14557(2002) 2.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007) 3.Hu, L., Zhang, T., Liu, D., et al.Notoamide-type alkaloid induced apoptosis and autophagy via a P38/JNK signaling pathway in hepatocellular carcinoma cellsRSC Adv.9(34)19855-19868(2019)

6-Acetyldepheline, a natural alkaloid, can be isolated from Delphinium tatsienense.

8-Demethoxycephatonine, an isoquinoline alkaloid, can be isolated from the plant Sinomenium acutum, which is part of the Menispermaceae family [1].

S-(-)-N-trans-Feruloyl normetanephrine, a natural product exhibiting weak anti-acetylcholinesterase activity, can be isolated from the aerial parts of Bassia indica Wight [1].

Methylenephenanthrene is a biochemical substance.

[D-Ala2]leucine-enkephalin acetate ([D-Ala2]leucine-enkephalin acetate (64963-01-5 free base)) is a delta opioid agonist used to study the signaling pathway of delta opioid receptors.

Elephanoside D (compound 8), a steroidal saponin, has been isolated from the stems of Yucca elephantipes Regel.

Experimental allergic encephalitogenic peptide (human), an EAE peptide, induces encephalomyelitis in guinea pigs [1].

Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibiting NF-kappaB activation and NF-kap

(R)-Mephenytoin ((–)-Mephenytoin) is the the R-enantiomer of Mephenytoin which is an anticonvulsant agent.

Dibutyl terephthalate is a biochemical.

Mephenesin (Cresoxydiol) is a centrally acting muscle relaxant with a short duration of action.

Blepharotriol, a phenolic triterpene isolated from Maytenus blepharodes, exhibits antimicrobial activity, with a minimum inhibitory concentration (MIC) of 8-4 µg/ml against Bacillus subtilis. It also demonstrates cytotoxic activity, with half-maximal inhibitory concentrations (IC50s) of 12.2 µM for HeLa cells, and greater than 20 µM for both Hep-2 and Vero cells [1].

Bis(2-ethylhexyl) terephthalate is an agent of biochemical.

11-Hydroxytephrosin inhibits NF-kappaB activity.

Phenylephrine-3-O-sulfate is metabolite of the α1A-adrenergic receptor agonist phenylephrine formed via sulfation.

Met-Enkephalin-Arg-Phe, a naturally occurring heptapeptide, exhibits analgesic activity [1].

Dibutylephrine is a sympathomimetic agent.

Cyclocephaloside II, a natural compound, is extractable from the roots of Astragalus brachypterus and Astragalus microcephalus [1].

Enkephalin, pen(2,5)- is a bioactive chemical.

9-O-Methylstecepharine (compound 7), an alkaloid present in Stephania cepharantha [1], is a naturally occurring compound.

Ethylnorepinephrine hydrochloride is a unique bronchodilator.

N-Acetylstepharine is a natural product for research related to life sciences. The catalog number is TN6067 and the CAS number is 4880-87-9.

Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.