monohydrate

Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.

Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.

α-L-Rhamnose monohydrate (6-deoxy-L-mannose monohydrate) is a component of bacterial polysaccharides where it plays an important role in pathogenicity.

Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.

Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Creatine monohydrate (Methylguanidoacetic acid monohydrate) is a key player in the phosphagen energy system, especially in muscle and the brain. Creatine monohydrate is the primary source of ATP during high-intensity, short-term activities.

Alpha-calcium ketoglutarate monohydrate is the calcium salt form of Alpha-ketoglutarate, which is involved in the tricarboxylic acid cycle in organisms.

Cefaclor monohydrate (Cefaclorum) is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.

HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.

Minodronic acid monohydrate is an farnesyl diphosphate synthase inhibitor that acts as a bone resorption inhibitor.

D-Glucuronic acid sodium salt monohydrate (Sodium D-glucuronate) is a carboxylic acid and highly soluble in water. In humans, glucuronic acid is often linked to toxic or poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport.

Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain.

Cilazapril Monohydrate (Justor) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.

Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

Adenosine 5'-monophosphate monohydrate (5'-AMP) , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. Adenosine 5'-monophosphate monohydrate consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.

o-Phenanthroline monohydrate (1, 10-Phenanthroline monohydrate) is an inhibitor of metallopeptidases, inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin.

Morin monohydrate (Aurantica) is a plant-derived flavonoid with weak antioxidant effect. Morin, as a fluorescent chelator, can be used in the generation process of aluminum species.

Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.

Gadobutrol is a medicinal product used in diagnostic magnetic resonance imaging (MRI) in adults and children. It provides contrast enhancement during cranial, spinal, breast, or other investigations. In the central nervous system, Gadobutrol works by high

L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange of aspartate and in other aspartate biological systems. L-Cysteic acid monohydrate is used in monomeric surfactant development. L-Cysteic acid monohydrate may be used in studies of excitatory amino acids in the brain, such as those that bind to cysteine sulfinic acid receptors. It is a useful agonist at several rat metabotropic glutamate receptors (mGluRs).

Calcium gluconate monohydrate is a useful organic compound for research related to life sciences. The catalog number is T35350 and the CAS number is 66905-23-5.

D-Galacturonic acid monohydrate is a natural product.

Doripenem monohydrate (S 4661 monohydrate) is a broad-spectrum injectable antibiotic, used for Gram-positive, Gram-negative and anaerobic pathogens.

Orotic acid monohydrate is an intermediate product in pyrimidine metabolism.

L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

Lactitol monohydrate (D-Lactitol monohydrate) is a disaccharide analog of lactulose. It has been widely used to treat constipation and hepatic encephalopathy.

Sodium picosulfate monohydrate (Sodium picosulfate hydrate) increases secretion of water and electrolytes and inhibits their absorption.

Methyl α-D-galactopyranoside monohydrate, an alpha-D-galactoside featuring a methyl substituent at the anomeric position, inhibits both extracellular and intracellular α-galactosidases of Debaryomyces hansenii UFV-1 with K i values of 0.82 mM and 1.12 mM, respectively [1].

Sedoheptulose anhydride monohydrate is a natural product.

Ipratropium bromide monohydrate (Ipratropium bromide hydrate) is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.

Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.

Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.

Fasoracetam monohydrate is a small synthetic molecule and a metabotropic glutamate receptor activator, which has previously undergone extensive Phase I-III clinical trials in humans for vascular dementia.

AT-1015 hydrochloride monohydrate is a serotonin (5-HT)2 receptor antagonist that blocks vascular and platelet 5-HT2A receptors.

Harmol hydrochloride monohydrate is a natural product for research related to life sciences. The catalog number is TN4184 and the CAS number is 40580-83-4.

Oxyphenbutazone monohydrate, a metabolite of Phenylbutazone, exhibits anti-inflammatory properties and acts as a non-selective COX inhibitor when taken orally. It also selectively targets and kills non-replicating Mycobacterium tuberculosis [1] [2].

Cetylpyridinium chloride monohydrate (Hexadecylpyridinium chloride monohydrate) , a cationic quaternary ammonium compound, is used in certain classes of throat sprays, mouthwashes, lozenges, toothpaste, nasal sprays, and breath sprays. Cetylpyridinium chloride monohydrate has also been used as an ingredient in certain pesticides. It is an antiseptic with killing bacteria and other microorganisms. It can be potent in reducing gingivitis and preventing dental plaque. It may result in brown stains between the teeth and on the surface of teeth.

Cloxacillin sodium monohydrate (Cloxacillin Sodium) is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity.

Galunisertib Monohydrate is a first-in-class transforming growth factor-β receptor type I inhibitor.

Cephalexin (Cefalexin) hydrochloride monohydrate is a potent, orally active, semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum against a wide range of gram-positive and gram-negative bacteria. It operates by targeting penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis. This compound is utilized in the research of various bacterial infections, including pneumonia, strep throat, and bacterial endocarditis [1] [2].

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2]. Animal Model: Rats.[2] [1]. Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. [2]. Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6.

L(+)-Monosodium glutamate monohydrate is a useful organic compound for research related to life sciences. The catalog number is T35369 and the CAS number is 6106-04-3.

Triacetonamine monohydrate is a natural product for research related to life sciences. The catalog number is T67286 and the CAS number is 10581-38-1.

Cephradine monohydrate, a first-generation cephalosporin, is active against a wide range of Gram-positive and Gram-negative bacteria.

Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative.

L(+)-Asparagine monohydrate is a non-essential amino acid, participate in neurological and metabolic regulation of tissue cell function.

Umifenovir hydrochloride monohydrate is an antiviral that inhibits membrane fusion by preventing contact between a virus and target host cells.

Lycorine hydrochloride monohydrate is a bioactive chemical.

Amlodipine mesylate monohydrate is a salt of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs, pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively).