tos peg4 ch2cooh

Tos-PEG4-CH2COOH is a PEG-based linker used in PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an efficient pegylated PROTAC linker commonly used in the synthesis of chloroanes (HaloPROTACs).

Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].

Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based linker utilized in the synthesis of PROTACs.

Amine-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

Cl-C6-PEG4-C3-COOH, a PROTAC linker, is a suitable component for synthesizing chloroalkane-containing PROTACs (HaloPROTACs).

Thiol-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derivative frequently used in the construction of PROTACs, bifunctional compounds designed for targeted protein degradation [1].

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized E3 ligase ligand-linker conjugate, incorporating the cereblon ligand from Pomalidomide and a linker used in PROTAC technology. It facilitates targeted protein degradation by modulating E3 ligase activity, thereby enabling the selective elimination of specific proteins of interest.

Propargyl-PEG4-CH2COOH is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Amine-PEG-CH2COOH (MW 3400) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs).

Amino-PEG4-CH2COOH is a PEG-based PROTAC linker and a non-cleavable 4-unit PEG ADC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs).

m-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].

Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Amine-PEG-CH2COOH (MW 2000) is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Thalidomide-NH-PEG4-COOH is a conjugate comprising an E3 ligase ligand-linker, utilized in the synthesis of dCBP-1. dCBP-1 itself functions as a powerful and selective heterobifunctional degrader targeting p300 CBP.

Thiol-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker used for the synthesis of PROTACs[1].

N-(Tos-PEG4)-N-bis(PEG4-Boc) is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs[1].

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker compound primarily used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Tos-PEG4-CH2-Boc is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands critical for the formation of PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Boc-Aminooxy-PEG4-Tos, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by joining two essential ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Mal-amido-(CH2COOH)2, also known as compound 7a, is an intermediate compound that contains maleimidoethyl for use in hydrophilic ADC linker synthesis[1].

m-PEG4-Tos, a PEG-based PROTAC linker derived from silybin ethers, finds application in the synthesis of Silymarin[1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

DSPE-PEG-CH2COOH (MW 2000) is a polyethylene glycol (PEG)-based linker molecule specifically designed for synthesizing protein-targeting chimeras (PROTACs)[1].

Hydroxy-PEG4-CH2COOH is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the [ubiquitin-proteasome system] within cells.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Tos-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

HOOCCH2O-PEG4-CH2COOH (compound 5), is a symmetric polyethylene glycol (PEG) linker. It is primarily utilized in the synthesis of the initial Homo-PROTAC[1] compound.

m-PEG4-CH2COOH is a PEG-based linker for PROTACs that combines two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG-CH2COOH (MW 20000) functions as a PEG-based PROTAC linker used in the synthesis of PROTACs[1].

m-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derived PROTAC linker used in the synthesis of PROTACs. [1]

SMARCA2 4-ligand-2 is a PROTAC target protein ligand.

(2-Pyridyldithio)-PEG4-propargyl is a polyethylene glycol (PEG)-based linker engineered for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Tos-PEG1-O-CH2COOH (PROTAC Linker 28) is a PEG-based linker used in the synthesis of PROTACs [1].

Fmoc-N-amido-PEG-CH2COOH (MW 5000), a PEG-based PROTAC linker, is used in PROTAC synthesis [1].

Tos-PEG2-CH2COOH, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition, crucial in synthesizing various PROTACs, including BI-3663, a selective PTK2 FAK PROTAC. Using cereblon ligands, it targets E3 ligases to degrade PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].

Tos-PEG4-THP is a polyethylene glycol (PEG) derivative utilized as a linker in the synthesis of PROTAC K-Ras Degrader-1, a potential therapeutic compound for targeted degradation of K-Ras protein [1].

Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based linker utilized in the synthesis of PROTACs[1].

Azido-PEG4-4-nitrophenyl carbonate, a PEG-derived PROTAC linker, enables the synthesis of PROTACs[1].

m-PEG-Tos (MW 2000) is a PEG-based linker utilized in PROTACs to join two essential ligands, facilitating the selective protein degradation through the ubiquitin-proteasome system within cells.

Tos-PEG3-CH2COOH is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

HO-PEG-CH2COOH (MW 3400) is a PEGylated PROTAC linker with a molecular weight of 3400, serving as a PEG-based building block for PROTAC synthesis[1].