CCR

Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. There have been 20 distinct chemokine receptors discovered in humans. Each has a rhodopsin-like 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling).

Cat No.	product name
T10156	CCR3 antagonist 1	CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
T10425	AZ084	AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T10708	CCR1 antagonist 6	CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
T10709	CCR1 antagonist 7	CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
T10710	CCR1 antagonist 9	CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T10711	CCR2 antagonist 1	CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T10712	CCR2 antagonist 3	CCR2 antagonist 3 is a CCR2 antagonist.
T10714	CCR5 antagonist 1	CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T10756	Cenicriviroc Mesylate	Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
T11472L	Molibresib besylate	Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
T11521	GW 766994	GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T11699	J-113863	J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive agains...
T11704	JAK-IN-3	JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T12076L	ML218	ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel...
T12419L	PF-04634817	PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 a...
T12773	RS102895 hydrochloride	RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T13410	ZLDI-8	ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T14307	Aplaviroc	Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T14373	AZD2423	AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for ...
T14688	BMS CCR2 22	BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) a...
T14899	CCR1 antagonist 8	CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T14900	CCR2-RA-[R]	CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
T14909	CCX140	CCX140 (CCX140-B) is an antagonist of CCR2.
T15253	CCX354	CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
T17274	YM022	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and hist...
T2375	BX471	BX471 is a potent, selective non-peptide CCR1 antagonist.
T3188	NSC5844	NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T3327	Arteether	Arteether is a new, fast-acting antimalarial drug.
T3360	ZK 756326	ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 ...
T3430	PF4136309	INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
T3435	Vicriviroc maleate	Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in c...
T4300	AZD2098	AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
T4584	BMS813160	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T4674	SB 297006
T5384	RS 504393	RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
T6016	Maraviroc	Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits H...
T6413	Bindarit	Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
T7499	TAK-779	TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T7624	DAPTA(TFA)	DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
TN2951	3-(hydroxymethyl)cyclopentanone	3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in th...
TQ0103	INCB3344	INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 n...
TQ0182	MK-0812	MK-0812 is an effective and specific CCR2 antagonist.
TQ0283	RS102895	RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
TQ0297	Cenicriviroc	Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...