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CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.
Cat No. product name
T17225 Vercirnon Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
T6016 Maraviroc Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-...
T30258 AZD-4818 AZD-4818 is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
T3188 NSC5844 NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T7499 TAK-779 TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T3435 Vicriviroc maleate Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in cl...
T7624 DAPTA DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
T3327 Artemotil Arteether is a new, fast-acting antimalarial drug.
T12773 RS102895 hydrochloride RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T16091 MK-0812 Succinate MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2.
T21870 C-021 C 021 dihydrochloride is a potent CCR4 antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 n...
T2386 Pirfenidone Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and tran...
TN1273 7,4'-Dihydroxyflavone 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
T2375 BX471 BX471 is a potent, selective non-peptide CCR1 antagonist.
T24700 R243 R243 is CCR8 signaling and chemotaxis inhibitor.
T10712 CCR2 antagonist 3 CCR2 antagonist 3 is a CCR2 antagonist.
T10711 CCR2 antagonist 1 CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T10710 CCR1 antagonist 9 CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T10709 CCR1 antagonist 7 CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
T10708 CCR1 antagonist 6 CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
T10714 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T10756 Cenicriviroc Mesylate Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
T10425 AZ084 AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T10156 CCR3 antagonist 1 CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
T12076L ML218 ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
T11699 J-113863 J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against...
T11704 JAK-IN-3 JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T11521 GW 766994 GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T11472L Molibresib besylate Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
T12419L PF-04634817 PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
TN2951 3-(hydroxymethyl)cyclopentanone 3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
TQ0283 RS102895 RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
TQ0297 Cenicriviroc Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory a...
TQ0182 MK-0812 MK-0812 is an effective and specific CCR2 antagonist.
TQ0103 INCB3344 INCB3344 是一种有效、特异性和口服生物可利用的 CCR2 拮抗剂,结合拮抗作用的 IC50 值为 9.5 nM (mCCR2) 和 5.1 nM (hCCR2),趋化活性拮抗作用的 IC50 值为 7.8 nM (mCCR2) 和 3.8 nM (hCCR2)。
T4300 AZD2098 AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
T4674 SB297006 SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ....
T4584 BMS-813160 BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T3360 ZK 756326 ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and ...
T3430 PF-4136309 INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
T6413 Bindarit Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
T5384 RS 504393 RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
T16111 ML604086 ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 bi...
T17274 YM022 YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
T14909 CCX140 CCX140 (CCX140-B) is an antagonist of CCR2.
T14899 CCR1 antagonist 8 CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T14900 CCR2-RA-[R] CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
T14688 BMS CCR2 22 BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) an...
T15253 CCX354 CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
T14373 AZD2423 AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
Vercirnon
T17225
Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
Maraviroc
T6016
Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HI...
AZD-4818
T30258
AZD-4818 is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
NSC5844
T3188
NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
TAK-779
T7499
TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
Vicriviroc maleate
T3435
Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in cl...
DAPTA
T7624
DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
Artemotil
T3327
Arteether is a new, fast-acting antimalarial drug.
RS102895 hydrochloride
T12773
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
MK-0812 Succinate
T16091
MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2.
C-021
T21870
C 021 dihydrochloride is a potent CCR4 antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 n...
Pirfenidone
T2386
Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and tr...
7,4'-Dihydroxyflavone
TN1273
4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
BX471
T2375
BX471 is a potent, selective non-peptide CCR1 antagonist.
R243
T24700
R243 is CCR8 signaling and chemotaxis inhibitor.
CCR2 antagonist 3
T10712
CCR2 antagonist 3 is a CCR2 antagonist.
CCR2 antagonist 1
T10711
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
CCR1 antagonist 9
T10710
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
CCR1 antagonist 7
T10709
CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
CCR1 antagonist 6
T10708
CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
CCR5 antagonist 1
T10714
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
Cenicriviroc Mesylate
T10756
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
AZ084
T10425
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
CCR3 antagonist 1
T10156
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
ML218
T12076L
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
J-113863
T11699
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against...
JAK-IN-3
T11704
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
GW 766994
T11521
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
Molibresib besylate
T11472L
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
PF-04634817
T12419L
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
3-(hydroxymethyl)cyclopentanone
TN2951
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
RS102895
TQ0283
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
Cenicriviroc
TQ0297
Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory a...
MK-0812
TQ0182
MK-0812 is an effective and specific CCR2 antagonist.
INCB3344
TQ0103
AZD2098
T4300
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
SB297006
T4674
SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ...
BMS-813160
T4584
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
ZK 756326
T3360
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 an...
PF-4136309
T3430
INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
Bindarit
T6413
Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
RS 504393
T5384
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
ML604086
T16111
ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 bi...
YM022
T17274
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
CCX140
T14909
CCX140 (CCX140-B) is an antagonist of CCR2.
CCR1 antagonist 8
T14899
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
CCR2-RA-[R]
T14900
CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
BMS CCR2 22
T14688
BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) an...
CCX354
T15253
CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
AZD2423
T14373
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
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