BX471 is a potent, selective non-peptide CCR1 antagonist. |
NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities. |
Arteether is a new, fast-acting antimalarial drug. |
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 a...
INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist. |
Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in c...
Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits H...
Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. |
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research. |
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter clinical development for cardiovascular. |
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1). |
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 n...
MK-0812 is an effective and specific CCR2 antagonist. |
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1. |
Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...
DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities. |
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. |
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for ...
||BMS CCR2 22
BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) a...
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma. |
||CCR1 antagonist 8
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay). |
CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM). |
CCX140 (CCX140-B) is an antagonist of CCR2. |
CCX354 is a CCR1antagonist. It has anti-inflammatory activity. |
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM). |
||CCR1 antagonist 6
CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM). |
||CCR1 antagonist 7
CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM). |
||CCR1 antagonist 9
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay). |
||CCR2 antagonist 1
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM). |
||CCR2 antagonist 3
CCR2 antagonist 3 is a CCR2 antagonist. |
||CCR3 antagonist 1
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases. |
||CCR5 antagonist 1
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication. |
GW 766994 has has the potential for asthma and eosinophilic bronchitis treatment.GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. |
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity. |
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. |
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively. |
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel...
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM). |
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 a...
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and hist...
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in th...