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Immunology/Inflammation CCR

CCR

Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. There have been 20 distinct chemokine receptors discovered in humans. Each has a rhodopsin-like 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling).
Cat No. product name
T10156 CCR3 antagonist 1 CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
T10425 AZ084 AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T10708 CCR1 antagonist 6 CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
T10709 CCR1 antagonist 7 CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
T10710 CCR1 antagonist 9 CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T10711 CCR2 antagonist 1 CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T10712 CCR2 antagonist 3 CCR2 antagonist 3 is a CCR2 antagonist.
T10714 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T10756 Cenicriviroc Mesylate Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
T11472L Molibresib besylate Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
T11521 GW 766994 GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T11699 J-113863 J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive agains...
T11704 JAK-IN-3 JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T12076L ML218 ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel...
T12419L PF-04634817 PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 a...
T12773 RS102895 hydrochloride RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T13410 ZLDI-8 ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T14307 Aplaviroc Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T14373 AZD2423 AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for ...
T14688 BMS CCR2 22 BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) a...
T14899 CCR1 antagonist 8 CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T14900 CCR2-RA-[R] CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
T14909 CCX140 CCX140 (CCX140-B) is an antagonist of CCR2.
T15253 CCX354 CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
T17274 YM022 YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and hist...
T2375 BX471 BX471 is a potent, selective non-peptide CCR1 antagonist.
T3188 NSC5844 NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T3327 Arteether Arteether is a new, fast-acting antimalarial drug.
T3360 ZK 756326 ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 ...
T3430 PF4136309 INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
T3435 Vicriviroc maleate Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in c...
T4300 AZD2098 AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
T4584 BMS813160 BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T4674 SB 297006
T5384 RS 504393 RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
T6016 Maraviroc Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits H...
T6413 Bindarit Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
T7499 TAK-779 TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T7624 DAPTA(TFA) DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
TN2951 3-(hydroxymethyl)cyclopentanone 3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in th...
TQ0103 INCB3344 INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 n...
TQ0182 MK-0812 MK-0812 is an effective and specific CCR2 antagonist.
TQ0283 RS102895 RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
TQ0297 Cenicriviroc Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...
CCR3 antagonist 1
T10156CAS 879399-82-3
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
AZ084
T10425CAS 929300-19-6
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
CCR1 antagonist 6
T10708CAS T10708
CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
CCR1 antagonist 7
T10709CAS T10709
CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
CCR1 antagonist 9
T10710CAS 1220026-26-5
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
CCR2 antagonist 1
T10711CAS 1683534-96-4
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
CCR2 antagonist 3
T10712CAS 1380100-86-6
CCR2 antagonist 3 is a CCR2 antagonist.
CCR5 antagonist 1
T10714CAS 716354-86-8
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
Cenicriviroc Mesylate
T10756CAS 497223-28-6
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
Molibresib besylate
T11472LCAS 1895049-20-3
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
GW 766994
T11521CAS 408303-43-5
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
J-113863
T11699CAS 353791-85-2
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive agains...
JAK-IN-3
T11704CAS 1400876-94-9
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
ML218
T12076LCAS 1346233-68-8
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel...
PF-04634817
T12419LCAS 1228111-63-4
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 a...
RS102895 hydrochloride
T12773CAS 1173022-16-6
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
ZLDI-8
T13410CAS 667880-38-8
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
Aplaviroc
T14307CAS 461443-59-4
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
AZD2423
T14373CAS 1229603-37-5
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for ...
BMS CCR2 22
T14688CAS 445479-97-0
BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) a...
CCR1 antagonist 8
T14899CAS 1295298-26-8
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
CCR2-RA-[R]
T14900CAS 512177-83-2
CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
CCX140
T14909CAS 1100318-47-5
CCX140 (CCX140-B) is an antagonist of CCR2.
CCX354
T15253CAS 1010073-75-2
CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
YM022
T17274CAS 145084-28-2
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and hist...
BX471
T2375CAS 217645-70-0
BX471 is a potent, selective non-peptide CCR1 antagonist.
NSC5844
T3188CAS 140926-75-6
NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
Arteether
T3327CAS 75887-54-6
Arteether is a new, fast-acting antimalarial drug.
ZK 756326
T3360CAS 874911-96-3
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 ...
PF4136309
T3430CAS 1341224-83-6
INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
Vicriviroc maleate
T3435CAS 599179-03-0
Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in c...
AZD2098
T4300CAS 566203-88-1
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
BMS813160
T4584CAS 1286279-29-5
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
SB 297006
T4674CAS 58816-69-6
RS 504393
T5384CAS 300816-15-3
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
Maraviroc
T6016CAS 376348-65-1
Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits H...
Bindarit
T6413CAS 130641-38-2
Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
TAK-779
T7499CAS 229005-80-5
TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
DAPTA(TFA)
T7624CAS 106362-34-9
DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
3-(hydroxymethyl)cyclopentanone
TN2951CAS 113681-11-1
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in th...
INCB3344
TQ0103CAS 1262238-11-8
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 n...
MK-0812
TQ0182CAS 624733-88-6
MK-0812 is an effective and specific CCR2 antagonist.
RS102895
TQ0283CAS 300815-41-2
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
Cenicriviroc
TQ0297CAS 497223-25-3
Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...