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CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.
Cat. No. Product name CAS No. Purity Chemical Structure
T11472L Molibresib besylate 1895049-20-3 98%
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
T26861 BMS-817399 1202400-18-7 98%
BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid ...
T10711 CCR2 antagonist 1 1683534-96-4 98%
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T14373 AZD2423 1229603-37-5 98%
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
T28072 MLN-3897 1010731-97-1 98%
MLN-3897 is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell ...
T10714 CCR5 antagonist 1 716354-86-8 98%
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T12076L ML218 1346233-68-8 98%
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
T12419L PF-04634817 1228111-63-4 98%
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
TN2951 3-(hydroxymethyl)cyclopentanone 113681-11-1 98%
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
T15253 CCX354 1010073-75-2 98%
CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
T11704 JAK-IN-3 1400876-94-9 98%
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T10708 CCR1 antagonist 6 2436773-01-0 98%
CCR1 antagonist 6 (compound 16q) is a chemokine receptor 1 (CCR1) antagonist, with an IC 50 of 3 nM [1].
TQ0182 MK-0812 624733-88-6 98%
MK-0812 is an effective and specific CCR2 antagonist.
T11521 GW 766994 408303-43-5 98%
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T17274 YM022 145084-28-2 98%
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
T14899 CCR1 antagonist 8 1295298-26-8 98%
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T10710 CCR1 antagonist 9 1220026-26-5 98%
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T10756 Cenicriviroc Mesylate 497223-28-6 98%
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
T30258 AZD-4818 1003566-93-5 98%
AZD-4818 is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
T10156 CCR3 antagonist 1 879399-82-3 98%
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
Molibresib besylate
T11472L
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
BMS-817399
T26861
BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid ...
CCR2 antagonist 1
T10711
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
AZD2423
T14373
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
MLN-3897
T28072
MLN-3897 is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell ...
CCR5 antagonist 1
T10714
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
ML218
T12076L
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
PF-04634817
T12419L
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
3-(hydroxymethyl)cyclopentanone
TN2951
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
CCX354
T15253
CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
JAK-IN-3
T11704
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
CCR1 antagonist 6
T10708
CCR1 antagonist 6 (compound 16q) is a chemokine receptor 1 (CCR1) antagonist, with an IC 50 of 3 nM [1].
MK-0812
TQ0182
MK-0812 is an effective and specific CCR2 antagonist.
GW 766994
T11521
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
YM022
T17274
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
CCR1 antagonist 8
T14899
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
CCR1 antagonist 9
T10710
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
Cenicriviroc Mesylate
T10756
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
AZD-4818
T30258
AZD-4818 is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
CCR3 antagonist 1
T10156
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
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