CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

Cat. No.	Product name	CAS No.	Purity
T10714	CCR5 antagonist 1	716354-86-8	98%
T10714	CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T14899	CCR1 antagonist 8	1295298-26-8	98%
T14899	CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T11704	JAK-IN-3	1400876-94-9	98%
T11704	JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T10709	CCR1 antagonist 7	2446154-74-9	98%
T10709	CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].
T15253	CCX354	1010073-75-2	98%
T15253	CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
T14307	Aplaviroc	461443-59-4	98%
T14307	Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T12076L	ML218	1346233-68-8	98%
T12076L	ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
T10711	CCR2 antagonist 1	1683534-96-4	98%
T10711	CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T17274	YM022	145084-28-2	98%
T17274	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
T14373	AZD2423	1229603-37-5	98%
T14373	AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
TQ0182	MK-0812	624733-88-6	98%
TQ0182	MK-0812 is an effective and specific CCR2 antagonist.
T11472L	Molibresib besylate	1895049-20-3	98%
T11472L	Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
T11521	GW 766994	408303-43-5	98%
T11521	GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T10710	CCR1 antagonist 9	1220026-26-5	98%
T10710	CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
TN2951	3-(hydroxymethyl)cyclopentanone	113681-11-1	98%
TN2951	3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
T10756	Cenicriviroc Mesylate	497223-28-6	98%
T10756	Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
T12419L	PF-04634817	1228111-63-4	98%
T12419L	PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
T13114	CCR2 antagonist 4	226226-39-7	98%
T13114	CCR2 antagonist 4 is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).
T14688	BMS CCR2 22	445479-97-0	98%
T14688	BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
T11699	J-113863	353791-85-2	98%
T11699	J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against...