PDGFR

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.

Cat. No.	Product name	CAS No.	Purity
T11523	GZD856	1257628-64-0	98%
T11523	GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.
T1991	ZM323881 hydrochloride	193000-39-4	98%
T1991	ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
T13039	Sunitinib-d10	1126721-82-1	98%
T13039	Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ...
T13178	Toceranib	356068-94-5	98%
T13178	Toceranib phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PD...
T12145	N-Desethyl Sunitinib	356068-97-8	98%
T12145	N-Desethyl Sunitinib is a sunitinib metabolite.
T10228	AC710 Mesylate	1351522-05-8	98%
T10228	AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).
T35331	Dovitinib (TKI258) Lactate		98%
T35331
T12396	PDGFRα kinase inhibitor 1	2209053-93-8	98%
T12396	PDGFRα kinase inhibitor 1 is a highly selective inhibitor of type II PDGFRα kinase (PDGFRα and PDGFRβ with IC50s of 132 nM and 6115 nM , respectively).
TQ0080	SU14813 maleate	849643-15-8	98%
TQ0080	SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
T6132	ENMD-2076 Tartrate	1291074-87-7	98%
T6132	ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more select...
T13156L	TG 100572 Hydrochloride	867331-64-4	98%
T13156L	TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
T2372L	Ponatinib Hydrochloride	1114544-31-8	98%
T2372L	Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
T13238	Tyrphostin AG1433	168835-90-3	98%
T13238	Tyrphostin AG1433 (SU1433) is an inhibitor of tyrosine kinases, and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor (IC50s: 5.0 μM and 9.3 μM, respecti...
TQ0235	AC710	1351522-04-7	98%
TQ0235	AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
T16947	SU16f	251356-45-3	98%
T16947	SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by S...
T11641	N-Desmethyl imatinib	404844-02-6
T11641	N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T14137	AG 1295	71897-07-9
T14137	AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG1295 abolishes autophosphorylation of the PDGFR. But it can n...
T9030	SU4984	186610-89-9	100%
T9030	SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
T8402	Regorafenib Hydrochloride	835621-07-3	100%
T8402	Regorafenib Hydrochloride is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor ac...
T3570	SU4312	5812-07-7	100%
T3570	SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexp...