TN4038 |
Eupatolide
|
6750-25-0
|
98%
|
|
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
|
T12396 |
PDGFRα kinase inhibitor 1
|
2209053-93-8
|
98%
|
|
PDGFRα kinase inhibitor 1 is a highly selective inhibitor of type II PDGFRα kinase (PDGFRα and PDGFRβ with IC50s of 132 nM and 6115 nM , respectively).
|
TQ0080 |
SU14813 maleate
|
849643-15-8
|
98%
|
|
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
|
T11523 |
GZD856
|
1257628-64-0
|
98%
|
|
GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.
|
T10228 |
AC710 Mesylate
|
1351522-05-8
|
98%
|
|
AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).
|
T13039 |
Sunitinib-d10
|
1126721-82-1
|
98%
|
|
Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ...
|
T12145 |
N-Desethyl Sunitinib
|
356068-97-8
|
98%
|
|
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
|
T14055 |
5Z-7-Oxozeaenol
|
253863-19-3
|
98%
|
|
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
|
T0080 |
Trapidil
|
15421-84-8
|
99.96%
|
|
Trapidil (Avantrin) is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients wit...
|
T6091 |
CP-673451
|
343787-29-1
|
99.93%
|
|
CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiog...
|
T2609 |
Masitinib
|
790299-79-5
|
99.91%
|
|
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
|
T60226 |
CT52923
|
205256-55-9
|
99.88%
|
|
CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatil...
|
T60110 |
KN1022
|
205255-11-4
|
99.88%
|
|
KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM.
|
T1792 |
Regorafenib
|
755037-03-7
|
99.87%
|
|
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active...
|
T6124 |
Mubritinib
|
366017-09-6
|
99.87%
|
|
Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.
|
T1777 |
Nintedanib
|
656247-17-5
|
99.85%
|
|
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108...
|
T0097L |
Pazopanib
|
444731-52-6
|
99.84%
|
|
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibi...
|
T7861 |
Flumatinib mesylate
|
895519-91-2
|
99.82%
|
|
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
|
T2500 |
Cediranib
|
288383-20-0
|
99.78%
|
|
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (I...
|
T2372 |
Ponatinib
|
943319-70-8
|
99.74%
|
|
Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively)...
|