16,17-epoxy docosapentaenoic acid

16,17-Epoxy-21-acetoxypregnenolone serves as an intermediate in pharmaceutical applications.

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]

5,6-epoxy-13-cis Retinoic Acid is a metabolite of 13-cis retinoic acid.

15,16-Epoxy-12R-hydroxylabda-8(17),13(16),14-triene is a natural product for research related to life sciences. The catalog number is TN2631 and the CAS number is 61597-55-5.

Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) is a natural product for research related to life sciences. The catalog number is TN6498 and the CAS number is 1309929-72-3.

Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-, a lanosterane-type compound, can be isolated from Tu-Jin-Pi, the root bark of Pseudolarix kaempferi [1].

16-hydroxy Hexadecanoic Acid (Juniperic acid) is a compound isolated from the leaves and stems of Arabidopsis thaliana and can be used to prevent, alleviate, or treat metabolic diseases.

all-trans-5,6-epoxy Retinoic Acid can be used in related research in the field of life sciences. Its product number is T36382 and CAS number is 13100-69-1.

8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione is a natural product for research related to life sciences. The catalog number is TN5610 and the CAS number is 76497-89-7.

ent-6,11-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3951 and the CAS number is 81263-97-0.

ent-3beta-Cinnamoyloxykaur-16-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3944 and the CAS number is 79406-10-3.

16-O-Acetylpolyporenic acid C is a natural product and can be used as a standard reference.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3956 and the CAS number is 77658-39-0.

15,16-Dihydro-15-methoxy-16-oxohardwickiic acid is a natural product for research related to life sciences. The catalog number is TN2629 and the CAS number is 115783-35-2.

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

11,15-Dihydroxy-16-kauren-19-oic acid is a natural product

Kaur-16-en-18-oic acid, 15-oxo- (7CI,8CI) is a useful organic compound for research related to life sciences. The catalog number is T124445 and the CAS number is 6620-00-4.

The compound is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase.

16-Acetoxy-6-oxo-7,13-labdadien-15-oic acid is a useful organic compound for research related to life sciences and the catalog number is T130200.

Docosapentaenoic acid 22n-3 is present in the cell membranes of all animals and is a component of phospholipids.

16-[(aminocarbonyl)hydrazono]stachan-18-oic acid is a useful organic compound for research related to life sciences and the catalog number is T131455.

16-Nor-7,15-dioxodehydroabietic acid is a useful organic compound for research related to life sciences and the catalog number is T126227.

ent-3beta-Hydroxykaur-16-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3949 and the CAS number is 66556-91-0.

15-Methoxy-16-oxo-15,16H-strictic acid is a natural product of Pulicaria, Asteraceae. The catalog number is TN6526 and the CAS number is 1356388-38-9. 15-Methoxy-16-oxo-15,16H-strictic acid can be used as a reference standard.

PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis

16-Acetoxy-17-hydroxy-7,13Z-labdadien-15-oic acid is a useful organic compound for research related to life sciences and the catalog number is T130199.

15-Hydroxy-16-kauren-19-oic acid is a useful organic compound for research related to life sciences and the catalog number is T131456.

16-Nor-15-oxodehydroabietic acid is a natural product from Pinus massoniana.

ent-11α,16α-Epoxy-15α-hydroxykauran-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5584 and the CAS number is 77658-46-9.

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

15,16-Epoxy-12S-hydroxylabda-8(17),13(16),14-triene is a natural product for research related to life sciences. The catalog number is TN2632 and the CAS number is 216011-55-1.

4,7,10,13,16-Docosapentaenoic acid is an endogenous metabolite.

All-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester, also known as Osbond acid, is an isomer of DPA and a more lipid-soluble variant of the free acid, primarily found in fish oils as an ω-3, 22-carbon fatty acid. Despite being an ω-6 fatty acid synthesized through the elongation and desaturation of arachidonic acid, its levels can decrease due to fatty acid desaturase syndrome, potentially impacting development. Additionally, increased expression of hepatic elongation of very long fatty acids protein 6 and elevated levels of very long-chain fatty acids, including all-cis-4,7,10,13,16-DPA, are indicative of nonalcoholic steatohepatitis, a condition that precedes hepatocellular carcinoma.

ent-3Beta-Tigloyloxykaur-16-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3950 and the CAS number is 79406-09-0.

ent-3Beta-Angeloyloxykaur-16-en-19-oic acid is a natural product of Wedelia, Asteraceae. The catalog number is TN3948 and the CAS number is 74635-61-3. ent-3Beta-Angeloyloxykaur-16-en-19-oic acid can be used as a reference standard.

4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 . While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3955 and the CAS number is 81263-96-9.

16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity.

ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3953 and the CAS number is 81264-00-8.

All-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of docosapentaenoic acid (DPA), an omega-3 fatty acid prevalent in fish oils. This ethyl ester form is commonly included in dietary supplements formulations to enhance omega-3 fatty acid intake.

12,15-Epoxy-13-methyl-12,14-eicosadienoic acid, a furan fatty acid first identified in northern pike (E. lucius), exhibits elevated levels in the liver of starving cod.

ent-15α-Acetoxy-11α-hydroxykaur-16-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5621 and the CAS number is 70324-38-8.

16-Hydroxy-8(17),13-labdadien-15,16-olid-19-oic acid may show a strong algicidal activity against Raphidocelis subcapitata.