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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16341 | Notch inhibitor 1 | Others | |
Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer. | |||
T19483 | Notch 1 TFA | Others | |
Notch 1 TFA encodes a member of the NOTCH family of proteins. | |||
T3540 | IMR-1A | Gamma-secretase , Drug Metabolite | |
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | |||
T12246 | CB-103 | Gamma-secretase | |
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity. | |||
T6861 | IMR-1 | Gamma-secretase | |
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | |||
T3075 | FLI-06 | FLI 06 | Gamma-secretase |
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM). | |||
T6063 | LY-411575 | LY411575 | Apoptosis , Gamma-secretase |
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM. | |||
T6249 | Avagacestat | BMS-708163 | Gamma-secretase |
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. | |||
T3633 | Crenigacestat | LY3039478 | Gamma-secretase |
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... | |||
T6202 | DAPT | LY-374973,GSI-IX | Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy |
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. | |||
T6274 | RO4929097 | RG-4733 | Beta Amyloid , Gamma-secretase |
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM). | |||
T6125 | Semagacestat | LY450139 | Beta Amyloid , Gamma-secretase |
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM). | |||
T13410 | ZLDI-8 | Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related | |
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. | |||
T6935 | Nirogacestat | PF-03084014,PF-3084014,PF03084014,PF 03084014 | Apoptosis , Gamma-secretase |
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay). | |||
T22678 | 3,5-Bis(4-nitrophenoxy)benzoic acid | Compound W | Gamma-secretase |
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). | |||
T6135 | YO-01027 | gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ | Gamma-secretase |
YO-01027 (DBZ) is a potent γ-secretase inhibitor. | |||
T1602 | Valproic acid sodium salt | Sodium Valproate | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy |
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha... | |||
T6474 | Divalproex Sodium | Valproate semisodium,Epival | HDAC |
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme... | |||
TP1540 | Jagged-1 (188-204) | Jagged-1 188-204 | Gamma-secretase |
Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolay... | |||
T3521 | γ-Secretase-IN-1 | Compound E | Beta Amyloid , Gamma-secretase |
γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage. | |||
T14680 | BMS-906024 | Osugacestat,AL-101,BM-0018 | Gamma-secretase |
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-... | |||
T31987 | Gossypolone | Wnt/beta-catenin , Gamma-secretase | |
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis. | |||
T21890 | JLK6 | Gamma-secretase | |
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling | |||
T9015 | LY900009 | Gamma-secretase | |
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. | |||
T35566 | RBPJ Inhibitor-1 | RIN1 | Gamma-secretase |
RBPJ Inhibitor-1 (RIN1) (RIN1), the RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation[1]. | |||
T76788 | Demcizumab | OMP 21M18 | Gamma-secretase |
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. Demcizumab is effective in multiple cancer models, both alone and in combination with chemotherapy agents. | |||
T11718 | JI051 | JI-051 | Gamma-secretase |
JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inh... | |||
T24159 | IHR-1 | IHR 1 | Smo |
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. | |||
TP1293 | Jagged-1 (188-204) TFA(219127-21-6 free base) | Jagged-1 (188-204) TFA | Gamma-secretase |
Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing sub... | |||
T12277 | NVS-ZP7-4 | Others | |
NVS-ZP7-4 is a inhibitor of Zinc transporter SLC39A7 (ZIP7). | |||
T2003 | ISX-9 | Isoxazole 9,Isoxazole 9 (ISX-9) | Calcium Channel , Wnt/beta-catenin |
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer. | |||
T6870 | L-685458 | L-685,458 | Apoptosis , Gamma-secretase |
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. | |||
T15184 | E 2012 | Gamma-secretase | |
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induc... | |||
T35546 | Yhhu 3792 | ||
Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes... | |||
TP2117 | SAHM1 | ||
Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly. | |||
T24210 | JNJ-40418677 | ||
JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch. | |||
T14683 | BMS-983970 | Gamma-secretase | |
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers. | |||
T76054 | SAHM1 TFA | ||
SAHM1 TFA is a Notch pathway inhibitor. SAHM1 TFA stabilizes hydrocarbon-stapled alpha helical peptide. SAHM1 TFA targets the protein-protein interface and prevents Notch complex assembly. | |||
T76023 | Jagged-1 (188-204) (TFA) | ||
Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation o... | |||
T13917 | TCFA15 | Others | |
tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, and may regulates Notch signaling, promotes the differentiation of neurons. | |||
T17281 | Z-Ile-Leu-aldehyde | Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII | Others |
Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch. | |||
T73485 | BT-GSI | ||
BT-GSI is a γ-secretase inhibitor (GSI) and a bone-targeted Notch inhibitor. BT-GSI has dual anti-myeloma and anti-resorptive properties, which can be used for the research of multiple myeloma and associated bone disease... | |||
T12634 | (R)-NVS-ZP7-4 | Others | |
(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as... | |||
T61930 | Yhhu-3792 | ||
Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 enhanced the self-renewal ability of neural stem cells (NSCs), expanded the NSC pool and promoted endogenous neurogenesi... | |||
T68980 | MRK003 | ||
MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM a... | |||
T80615 | Enoticumab | REGN421 | |
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody that specifically targets human Delta-like ligand 4 (Dll4), which serves as a crucial component of the Notch signaling pathway and regulates the uptake of fatty acids ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TWS2045 | Bruceine D | Apoptosis , Antiviral , Gamma-secretase , Parasite | |
1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW... | |||
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
T4S1990 | Carvacrol | Karvakrol,O-Thymol,cymophenol | Apoptosis , Others , Gamma-secretase , Endogenous Metabolite , Antifungal |
1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopami... | |||
T2842 | Tangeretin | NSC53909,Tangeritin,NSC618905 | Apoptosis , Gamma-secretase |
Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notc... | |||
T7064 | Valproic Acid | Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy |
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research. | |||
T7982 | 3,6-Dihydroxyflavone | Others | |
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. | |||
T3426 | Bacoside A | MMP , Others , TNF , Dopamine Receptor , NOS , ROS | |
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidat... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05054 | Notch 4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The NOTCH4 gene is located at 6p21.3 and is i... | |||
TMPY-05081 | Notch 1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair... | |||
TMPK-01396 | Notch 3 Protein, Human, Recombinant (His) | Human | HEK293 |
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular dom... | |||
TMPK-01367 | Notch 3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular dom... | |||
TMPK-01374 | Notch 3 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular dom... | |||
TMPK-01360 | Notch 3 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular dom... | |||
TMPK-00868 | Notch 4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The Notch signaling pathway is important for cell-cell communication; it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression ... | |||
TMPY-02663 | Notch 1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair... | |||
TMPY-04930 | Notch 2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev... | |||
TMPJ-01452 | Notch 1 Protein, Mouse, Recombinant (aa 18-526, His) | Mouse | Human Cells |
Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531... | |||
TMPY-00415 | Notch 1 Protein, Mouse, Recombinant (hFc) | Mouse | CHO |
NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair... | |||
TMPK-00465 | Notch 2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of ... | |||
TMPK-00467 | Notch 1 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagg... | |||
TMPK-00466 | Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of ... | |||
TMPK-00468 | Notch 1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagg... | |||
TMPY-05028 | NOTCH2NL Protein, Human, Recombinant (mFc) | Human | HEK293 |
NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. NOTCH2NL, human-specific paralogs of the NOTCH2 receptor, stood out for their ability to promote cortical progenitor maintenance. It belongs to the NOTCH fa... | |||
TMPK-00360 | DLL4 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell pro... | |||
TMPH-01783 | NOTCH2NLB Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
TMPH-01784 | NOTCH2NLB Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
TMPY-01379 | DLL1 Protein, Human, Recombinant (His) | Human | HEK293 |
Delta-like protein 1(DLL1), also known as Delta1, a single-pass type I membrane protein which contains one DSL domain and eight EGF-like domains, acts as a ligand for Notch receptors, and positively regulates T-cell deve... | |||
TMPY-01915 | DLL1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Delta-like protein 1(DLL1), also known as Delta1, a single-pass type I membrane protein which contains one DSL domain and eight EGF-like domains, acts as a ligand for Notch receptors, and positively regulates T-cell deve... | |||
TMPY-05833 | DLL1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Delta-like protein 1(DLL1), also known as Delta1, a single-pass type I membrane protein which contains one DSL domain and eight EGF-like domains, acts as a ligand for Notch receptors, and positively regulates T-cell deve... | |||
TMPY-01321 | DLL4 Protein, Human, Recombinant (His) | Human | HEK293 |
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud... | |||
TMPY-04803 | DLL4 Protein, Human, Recombinant | Human | HEK293 |
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud... | |||
TMPY-01337 | DLL4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud... | |||
TMPY-00776 | DLL4 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud... | |||
TMPY-01475 | Jagged 1 Protein, Human, Recombinant (His) | Human | HEK293 |
Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expre... | |||
TMPH-01605 | BAG6 Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly b... | |||
TMPY-02123 | DLL1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Delta-like protein 1(DLL1), also known as Delta1, a single-pass type I membrane protein which contains one DSL domain and eight EGF-like domains, acts as a ligand for Notch receptors, and positively regulates T-cell deve... | |||
TMPY-04098 | DLL1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Delta-like protein 1(DLL1), also known as Delta1, a single-pass type I membrane protein which contains one DSL domain and eight EGF-like domains, acts as a ligand for Notch receptors, and positively regulates T-cell deve... | |||
TMPH-01604 | SLC7A5 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly b... | |||
TMPH-02567 | CCL4 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular... | |||
TMPY-06876 | DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud... | |||
TMPY-05796 | DLL4 Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 |
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud... | |||
TMPY-05093 | DLL4 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud... | |||
TMPK-00945 | ASPH Protein, Human, Recombinant (His) | Human | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPK-01083 | ASPH Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPH-01238 | POLQ Protein, Human, Recombinant (His) | Human | Baculovirus |
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamm... | |||
TMPY-03276 | BLBP Protein, Human, Recombinant | Human | E. coli |
BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic l... | |||
TMPH-01489 | HLA-DPA1 Protein, Human, Recombinant (His) | Human | E. coli |
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal developmen... | |||
TMPK-01209 | DLL3 Protein, Human, Recombinant (His) | Human | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-00748 | DLL3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-00543 | DLL3 Protein, Cynomolgus, Recombinant (aa 27-477, His) | Cynomolgus | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-00640 | DLL3 Protein, Rhesus macaque, Recombinant (His) | Rhesus macaque | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-01207 | DLL3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-00542 | DLL3 Protein, Cynomolgus, Recombinant (aa 27-488, His) | Cynomolgus | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-01208 | DLL3 Protein, Human, Recombinant (His & Flag) | Human | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPY-03308 | ADAM17 Protein, Rat, Recombinant (His) | Rat | HEK293 |
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative coliti... | |||
TMPK-01206 | DLL3 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-01210 | DLL3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
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Cat No. | Product Name | ||
---|---|---|---|
L4300 | Wnt/Hedgehog/Notch Compound Library | 240 compounds | |
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; | |||
L2600 | Neuronal Signaling Compound Library | 2540 compounds | |
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L7900 | Osteogenesis Compound Library | 320 compounds | |
A unique collection of 320 osteogenesis related compounds for high throughput and high content screening; | |||
L7700 | Neural Regeneration Compound Library | 529 compounds | |
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening; |