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Membrane transporter/Ion channel ATPase

ATPase

ATPases ( adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, adenosine 5'-triphosphatase, ATP hydrolase, complex V (mitochondrial electron transport), (Ca2+ + Mg2+)-ATPase, HCO3−-ATPase, adenosine triphosphatase) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion[1][2][3][4][5][6] or the inverse reaction. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur.
Cat No. product name
T0114 Trichlormethiazide Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appea...
T0126 Diazoxide Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it l...
T0859 Fenbufen Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also ...
T1114 Ciclopirox ethanolamine Ciclopirox Olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
T1482 Ciclopirox Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors f...
T1670 Lanatoside C Lanatoside C is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). ...
T1719 Bufalin Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from ...
T1940 BTB06584 BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising ...
T2006 Omecamtiv mecarbil Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, a...
T2089 Eniporide Eniporide is a Na(+)/H(+) exchange inhibitor.
T2093 PF 03716556 PF 3716556, an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.
T2189 Sodium orthovanadate Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase trans...
T2404 Vonoprazan fumarate Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase.
T2405 Revaprazan hydrochloride Revaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.
T2621 Rostafuroxin Rostafuroxin has been used in trials studying the treatment of Essential Hypertension.
T2686 Esomeprazole Magnesium Esomeprazole Magnesium is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.
T2686L Esomeprazole Sodium Esomeprazole Sodium is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.
T3432 Cinobufagin Cinobufagin is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.
T3480 Sudoterb free base Sudoterb, also known as LL3858, is an anti-tubercular drug candidate.
T4190 Ticlopidine Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
T6038 (-)-Blebbistatin (-)-Blebbistatin is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM.
T6062 Brefeldin A Brefeldin A , a Penicillium brefeldianum metabolite, which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. It is also an ATPase inhibit...
T6323 Oligomycin A Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitoc...
T6587 Mitiglinide Calcium Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
T3578 Pyridoxal phosphate Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic ...
T7411 Rbin-1 Rbin-1 is a potent,specific inhibitor of eukaryotic ribosome biogenesis.
T7540 BHQ BHQ is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
TQ0184 Chebulinic acid Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
T2537 Tirofiban hydrochloride monohydrate Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
T7144 BTS BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) .
T1496 Amiodarone hydrochloride Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting PO...
T1137 Clorsulon Clorsulon is utilized for the treatment of Fasciola hepatica infections in calves and sheep.
T4861 trans-Aconitic acid Trans-Aconitic acid is normally present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic acid...
T6S1049 Wilforine Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis....
T8183 Deslanoside Deslanoside is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside...
TN1103 Diphyllin Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
TN1610 Epimagnolin A Epimagnolin A affects the transport activity of ABCB1(a major transmembrane efflux pump belonging to the ABC transporter superfamily), it also exhibits growth i...
TN2215 Sodium taurochenodeoxycholate Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of α²-cells and enhance cytosolic Ca(2+) co...
TN1421 Bacopaside II Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.
TN1588 Dihydroisotanshinone I Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
TN1711 Gossypetin Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects, it inhibits bone resorption through down-...
TN1860 Licoflavone B Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities.
TN1874 Liriodendrin Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
TN1912 Marinobufagenin Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
TN1916 Matairesinol Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-induci...
TN2148 Retusin Retusin behaves as pre- and postemergent herbicides. Retusin is a weak inhibitor of ATP synthesis; it exhibits potent free-radical-scavenging capacities as well...
TN2239 Strictosamide Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
TN2306 Wilfordine Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
TN1425 Bacoside A3 Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
Trichlormethiazide
T0114CAS 133-67-5
Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appea...
Diazoxide
T0126CAS 364-98-7
Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it l...
Fenbufen
T0859CAS 36330-85-5
Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also ...
Ciclopirox ethanolamine
T1114CAS 41621-49-2
Ciclopirox Olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
Ciclopirox
T1482CAS 29342-05-0
Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors f...
Lanatoside C
T1670CAS 17575-22-3
Lanatoside C is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). ...
Bufalin
T1719CAS 465-21-4
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from ...
BTB06584
T1940CAS 219793-45-0
BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising ...
Omecamtiv mecarbil
T2006CAS 873697-71-3
Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, a...
Eniporide
T2089CAS 176644-21-6
Eniporide is a Na(+)/H(+) exchange inhibitor.
PF 03716556
T2093CAS 928774-43-0
PF 3716556, an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.
Sodium orthovanadate
T2189CAS 13721-39-6
Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase trans...
Vonoprazan fumarate
T2404CAS 1260141-27-2
Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase.
Revaprazan hydrochloride
T2405CAS 178307-42-1
Revaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.
Rostafuroxin
T2621CAS 156722-18-8
Rostafuroxin has been used in trials studying the treatment of Essential Hypertension.
Esomeprazole Magnesium
T2686CAS 161973-10-0
Esomeprazole Magnesium is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.
Esomeprazole Sodium
T2686LCAS 161796-78-7
Esomeprazole Sodium is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.
Cinobufagin
T3432CAS 470-37-1
Cinobufagin is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.
Sudoterb free base
T3480CAS 676266-31-2
Sudoterb, also known as LL3858, is an anti-tubercular drug candidate.
Ticlopidine
T4190CAS 55142-85-3
Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
(-)-Blebbistatin
T6038CAS 856925-71-8
(-)-Blebbistatin is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM.
Brefeldin A
T6062CAS 20350-15-6
Brefeldin A , a Penicillium brefeldianum metabolite, which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. It is also an ATPase inhibit...
Oligomycin A
T6323CAS 579-13-5
Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitoc...
Mitiglinide Calcium
T6587CAS 145525-41-3
Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
Pyridoxal phosphate
T3578CAS 54-47-7
Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic ...
Rbin-1
T7411CAS 328023-11-6
Rbin-1 is a potent,specific inhibitor of eukaryotic ribosome biogenesis.
BHQ
T7540CAS 88-58-4
BHQ is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
Chebulinic acid
TQ0184CAS 18942-26-2
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
Ellagic acid
T0465CAS 476-66-4
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
Tirofiban hydrochloride monohydrate
T2537CAS 150915-40-5
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
BTS
T7144CAS 1576-37-0
BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) .
Amiodarone hydrochloride
T1496CAS 19774-82-4
Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting PO...
Clorsulon
T1137CAS 60200-06-8
Clorsulon is utilized for the treatment of Fasciola hepatica infections in calves and sheep.
trans-Aconitic acid
T4861CAS 4023-65-8
Trans-Aconitic acid is normally present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic acid...
Wilforine
T6S1049CAS 11088-09-8
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis....
Deslanoside
T8183CAS 17598-65-1
Deslanoside is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside...
Diphyllin
TN1103CAS 22055-22-7
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
Epimagnolin A
TN1610CAS 41689-51-4
Epimagnolin A affects the transport activity of ABCB1(a major transmembrane efflux pump belonging to the ABC transporter superfamily), it also exhibits growth i...
Sodium taurochenodeoxycholate
TN2215CAS 6009-98-9
Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of α²-cells and enhance cytosolic Ca(2+) co...
Bacopaside II
TN1421CAS 382146-66-9
Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.
Dihydroisotanshinone I
TN1588CAS 20958-18-3
Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
Gossypetin
TN1711CAS 489-35-0
Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects, it inhibits bone resorption through down-...
Licoflavone B
TN1860CAS 91433-17-9
Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities.
Liriodendrin
TN1874CAS 573-44-4
Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
Marinobufagenin
TN1912CAS 470-42-8
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
Matairesinol
TN1916CAS 580-72-3
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-induci...
Retusin
TN2148CAS 1245-15-4
Retusin behaves as pre- and postemergent herbicides. Retusin is a weak inhibitor of ATP synthesis; it exhibits potent free-radical-scavenging capacities as well...
Strictosamide
TN2239CAS 23141-25-5
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
Wilfordine
TN2306CAS 37239-51-3
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
Bacoside A3
TN1425CAS 157408-08-7
Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.