T0114 |
Trichlormethiazide |
Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appea...
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T0126 |
Diazoxide |
Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it l...
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T0295 |
Digitoxin |
Digitoxin is an effective Na+/K+-ATPase inhibitor (EC50 value: 0.78 μM). |
T0465 |
Ellagic acid |
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
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T0859 |
Fenbufen |
Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also ...
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T1114 |
Ciclopirox ethanolamine |
Ciclopirox Olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. |
T1137 |
Clorsulon |
Clorsulon is utilized for the treatment of Fasciola hepatica infections in calves and sheep. |
T1482 |
Ciclopirox |
Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors f...
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T1496 |
Amiodarone hydrochloride |
Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting PO...
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T15373 |
Gboxin |
Gboxin inhibits the activity of F0F1 ATP synthase. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma with antitumor activity. |
T1670 |
Lanatoside C |
Lanatoside C is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). ...
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T16865 |
SCH28080 |
SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding (IC50: 20 nM in rabbit microsomal membranes). |
T17030 |
Tegoprazan |
Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gast...
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T1719 |
Bufalin |
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from ...
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T1940 |
BTB06584 |
BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising ...
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T2006 |
Omecamtiv mecarbil |
Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, a...
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T2089 |
Eniporide |
Eniporide is a Na(+)/H(+) exchange inhibitor. |
T2093 |
PF 03716556 |
PF 3716556, an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease. |
T2189 |
Sodium orthovanadate |
Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase trans...
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T2404 |
Vonoprazan fumarate |
Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase. |
T2405 |
Revaprazan hydrochloride |
Revaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. |
T2537 |
Tirofiban hydrochloride monohydrate |
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist. |
T2621 |
Rostafuroxin |
Rostafuroxin has been used in trials studying the treatment of Essential Hypertension. |
T2686 |
Esomeprazole Magnesium |
Esomeprazole Magnesium is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomepra...
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T2686L |
Esomeprazole Sodium |
Esomeprazole Sodium is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by bl...
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T2S0820 |
Karanjin |
Karanjin is a potent Volume-regulated anion channels(VRACs) current inhibitor, the VRAC inhibition might be responsible for its anti-angiogenic effects. Karanji...
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T2S1635 |
3-Isomangostin |
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has ...
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T3229 |
Cytochalasin D |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertili...
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T3432 |
Cinobufagin |
Cinobufagin is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain. |
T3480 |
Sudoterb free base |
Sudoterb, also known as LL3858, is an anti-tubercular drug candidate. |
T3578 |
Pyridoxal phosphate |
Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic ...
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T3S0870 |
Paederosidic acid methyl ester |
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels. |
T4190 |
Ticlopidine |
Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. |
T4861 |
trans-Aconitic acid |
Trans-Aconitic acid is normally present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic acid...
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T6038 |
(-)-Blebbistatin |
(-)-Blebbistatin is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM. |
T6062 |
Brefeldin A |
Brefeldin A , a Penicillium brefeldianum metabolite, which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. It is also an ATPase inhibit...
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T6323 |
Oligomycin A |
Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitoc...
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T6587 |
Mitiglinide Calcium |
Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
T6S1049 |
Wilforine |
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis....
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T7144 |
BTS |
BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) . |
T7190 |
Actein |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblas...
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T7411 |
Rbin-1 |
Rbin-1 is a potent,specific inhibitor of eukaryotic ribosome biogenesis. |
T7540 |
BHQ |
BHQ is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor. |
T8183 |
Deslanoside |
Deslanoside is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside...
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TMA0805 |
Lupanine |
Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lup...
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TN1103 |
Diphyllin |
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. |
TN1421 |
Bacopaside II |
Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis. |
TN1425 |
Bacoside A3 |
Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS. |
TN1588 |
Dihydroisotanshinone I |
Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
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TN1610 |
Epimagnolin A |
Epimagnolin A affects the transport activity of ABCB1(a major transmembrane efflux pump belonging to the ABC transporter superfamily), it also exhibits growth i...
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TN1711 |
Gossypetin |
Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects, it inhibits bone resorption through down-...
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TN1860 |
Licoflavone B |
Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities. |
TN1874 |
Liriodendrin |
Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
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TN1912 |
Marinobufagenin |
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. |
TN1916 |
Matairesinol |
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-induci...
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TN2054 |
Periplocymarin |
Periplocymarin, a cardiac glycoside, has potential anti-cancer activity. |
TN2148 |
Retusin |
Retusin behaves as pre- and postemergent herbicides. Retusin is a weak inhibitor of ATP synthesis; it exhibits potent free-radical-scavenging capacities as well...
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TN2215 |
Sodium taurochenodeoxycholate |
Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of α²-cells and enhance cytosolic Ca(2+) co...
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TN2239 |
Strictosamide |
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain. |
TN2306 |
Wilfordine |
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect. |
TN2945 |
3-Hydroxybakuchiol |
3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondr...
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TN3042 |
4-Hydroxycinnamamide |
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. |
TN3075 |
5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone |
5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell. |
TN3209 |
7,3',4'-Trihydroxyflavone |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bon...
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TN3460 |
Asebogenin |
Asebogenin has anti-bacterial activity, it shows inhibitory activity against S. aureus and methicillin-resistant S. aureus (IC50 of 10 and 4.5 micrograms/ml, re...
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TN3557 |
Cabraleadiol |
Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol...
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TN3575 |
Cannabichromene |
Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1...
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TN3627 |
Chalepensin |
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential ...
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TN3737 |
Cycloartane-3,24,25-triol |
Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines w...
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TN3831 |
Denudatin B |
Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
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TN3910 |
Ecdysone |
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
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TN3914 |
Echinatine |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant an...
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TN3930 |
Encecalin |
Encecalin and demethylencecalin are major phytotoxic compounds isolated from Helianthella quinquenervis (Hook) A Gray (Asteraceae), they inhibit photosystem II ...
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TN4160 |
Goniothalamin |
Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cel...
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TN4303 |
Isokaempferide |
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
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TN4322 |
Isopulegol |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly r...
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TN4418 |
Lasiodiplodin |
Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron tra...
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TN4697 |
Odoroside H |
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase. |
TN4819 |
(-)-Praeruptorin A |
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depe...
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TN5060 |
Stauntosaponin A |
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively. |
TN5141 |
Thevetin B |
Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors. |
TN5279 |
Zeorin |
Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP2...
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TQ0184 |
Chebulinic acid |
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. |