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DUB

Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions.DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases.
Cat No. product name
T1937 Spautin-1 Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induc...
T6300 Degrasyn Degrasyn (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without a...
T11464 GRL0617 GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).
T1932 B-AP15 B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the ...
T36682 USP30 inhibitor 18 USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]....
T3088 N-Ethylmaleimide N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T6107 IU1 IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
T7685 USP25/28 inhibitor AZ1 USP25/28 inhibitor AZ1 (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28
T1924 LDN-57444 LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
T3089 6-Thioguanine Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T1902 BAY 11-7082 BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
T1862 PR-619 PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).
T21527 HBX 41108 HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-depend...
T8464 RA-9 RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
T12024 MF-094 MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM).
T9375 IU1-248 IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].
T2424 P 22077 P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
T9217 USP7-IN-8 Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. US...
T9122 XL177A XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
T7678 SJB2-043 SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
T13271 USP7-IN-6 USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).
T13270 USP7-IN-5 USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).
T13269 USP7-IN-3 USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
T13268 USP7-IN-1 USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 77 μM) and used for cancer.
T11112 DUB-IN-3 DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.
T11111 DUB-IN-2 Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
T11110 DUB-IN-1 DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
T12621L FT671 FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
T11485 GSK2643943A GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor (IC50: 160 nM for USP20/Ub-Rho).
T11209 EOAI3402143 EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits  Usp5/Usp24 andUsp9x.
T6925 P005091 P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
T5461 GNE-6640 GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, US...
T6697 TCID TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
T4338 USP7/USP47 inhibitor USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
T4634 GNE-6776 GNE-6776 is a selective USP7 inhibitor.
T4067 VLX1570 VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.
T3951 NSC632839 NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM).
T3555 ML364 ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
T14852 C527 C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
T15351 FT827 FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 µM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 µM)....
T15464 HBX 19818 HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
T1757 ML-323 ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (...
T15604 IU1-47 IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
T15729 LDN-91946 LDN-91946 是一种有效且特异性的泛素 C-末端水解酶-L1 (UCH-L1) 抑制剂(Ki = 2.8 μM)。
Spautin-1
T1937
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-indu...
Degrasyn
T6300
Degrasyn (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without a...
GRL0617
T11464
GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).
B-AP15
T1932
B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the ...
USP30 inhibitor 18
T36682
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]...
N-Ethylmaleimide
T3088
N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
IU1
T6107
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
USP25/28 inhibitor AZ1
T7685
USP25/28 inhibitor AZ1 (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28
LDN-57444
T1924
LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
6-Thioguanine
T3089
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
BAY 11-7082
T1902
BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
PR-619
T1862
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).
HBX 41108
T21527
HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-depend...
RA-9
T8464
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
MF-094
T12024
MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM).
IU1-248
T9375
IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].
P 22077
T2424
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
USP7-IN-8
T9217
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. U...
XL177A
T9122
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
SJB2-043
T7678
SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
USP7-IN-6
T13271
USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).
USP7-IN-5
T13270
USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).
USP7-IN-3
T13269
USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
USP7-IN-1
T13268
USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 77 μM) and used for cancer.
DUB-IN-3
T11112
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.
DUB-IN-2
T11111
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
DUB-IN-1
T11110
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
FT671
T12621L
FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
GSK2643943A
T11485
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor (IC50: 160 nM for USP20/Ub-Rho).
EOAI3402143
T11209
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits  Usp5/Usp24 andUsp9x.
P005091
T6925
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
GNE-6640
T5461
GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7...
TCID
T6697
TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
USP7/USP47 inhibitor
T4338
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
GNE-6776
T4634
GNE-6776 is a selective USP7 inhibitor.
VLX1570
T4067
VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.
NSC632839
T3951
NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM).
ML364
T3555
ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
C527
T14852
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
FT827
T15351
FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 µM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 µM...
HBX 19818
T15464
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
ML-323
T1757
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (...
IU1-47
T15604
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM)....
LDN-91946
T15729
LDN-91946 是一种有效且特异性的泛素 C-末端水解酶-L1 (UCH-L1) 抑制剂(Ki = 2.8 μM)。