T13271 |
USP7-IN-6
|
2166586-47-4
|
98%
|
|
USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).
|
T15351 |
FT827
|
1959537-86-0
|
98%
|
|
FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 µM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 µM)....
|
T13269 |
USP7-IN-3
|
2202738-42-7
|
98%
|
|
USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
|
T13270 |
USP7-IN-5
|
2166599-74-0
|
98%
|
|
USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).
|
T12621L |
FT671
|
1959551-26-8
|
98%
|
|
FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
|
T15729 |
LDN-91946
|
439946-22-2
|
98%
|
|
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
|
T36682 |
USP30 inhibitor 18
|
2242582-40-5
|
98%
|
|
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1].
[1]....
|
T11112 |
DUB-IN-3
|
924296-17-3
|
|
|
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.
|
T3089 |
6-Thioguanine
|
154-42-7
|
100%
|
|
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
|
T4634 |
GNE-6776
|
2009273-71-4
|
96.59%
|
|
GNE-6776 is a selective USP7 inhibitor.
|
T14852 |
C527
|
192718-06-2
|
97.64%
|
|
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
|
T3088 |
N-Ethylmaleimide
|
128-53-0
|
98%
|
|
N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
|
T1932 |
B-AP15
|
1009817-63-3
|
98%
|
|
B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the ...
|
T1937 |
Spautin-1
|
1262888-28-7
|
98%
|
|
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induc...
|
T60146 |
USP8-IN-1
|
2477650-96-5
|
98.01%
|
|
USP8-IN-1 is a USP8 inhibitor with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM (CN111138358A; U10) [1].
|
T11485 |
GSK2643943A
|
2449301-27-1
|
98.06%
|
|
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho.
|
T11209 |
EOAI3402143
|
1699750-95-2
|
98.09%
|
|
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp5/Usp24 andUsp9x.
|
T2424 |
P 22077
|
1247819-59-5
|
98.42%
|
|
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
|
T9217 |
USP7-IN-8
|
2009273-60-1
|
98.48%
|
|
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. US...
|
T4338 |
USP7/USP47 inhibitor
|
1247825-37-1
|
98.5%
|
|
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
|