FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Cat. No.	Product name	CAS No.	Purity
T3512	S49076 HCl	1265966-31-1	98%
T3512	S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
T6036	Brivanib	649735-46-6	98%
T6036	Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
T10870	CP-547632 hydrochloride	252003-71-7	98%
T10870	CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
T1991	ZM323881 hydrochloride	193000-39-4	98%
T1991	ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
T11280	FGFR4-IN-4	2230973-67-6	98%
T11280	FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
T13003	SSR128129E free acid	848463-13-8	98%
T13003	SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
T6193	Dovitinib Dilactic Acid	852433-84-2	98%
T6193	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T35331	Dovitinib (TKI258) Lactate		98%
T35331
T6132	ENMD-2076 Tartrate	1291074-87-7	98%
T6132	ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more select...
T16781	Rogaratinib	1443530-05-9	98%
T16781	Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
T10870L	CP-547632	252003-65-9	98%
T10870L	CP-547632 is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50s: 11 nM and 9 nM) with antitum...
T8525	EGFR-IN-16	133550-22-8	98%
T8525	AG473 is an inhibitor of EGFR in human A431 cells.
T2372L	Ponatinib Hydrochloride	1114544-31-8	98%
T2372L	Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
T16364	Infigratinib phosphate	1310746-10-1	98%
T16364	Infigratinib phosphate is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
T13156L	TG 100572 Hydrochloride	867331-64-4	98%
T13156L	TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
T6154	SU11274	658084-23-2
T6154	SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
T19355	Heparan Sulfate	9050-30-0
T19355	Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
T1338	Sucralfate	54182-58-0
T1338	Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
T7104	Dovitinib lactate	692737-80-7	100%
T7104	Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
T2S0007	Ferulic acid sodium	24276-84-4	100%
T2S0007	Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...