MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

Cat No.	product name
T38796L	MBP MAPK Substrate acetate	MBP MAPK Substrate acetate 可用作 MAPK 的外源性底物。
T9880	ZINC05007751	ZINC05007751 是 NIMA 相关激酶 NEK6 的有效抑制剂（IC50 = 3.4 μM）。 ZINC05007751 对 NEK1 和 NEK6 具有很强的特异性，对 NEK2、NEK7 和 NEK9 没有显着的活性。
T3410	Momordin Ic	Momordin Ic might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAP...
T14072	A-443654	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T12237	NMS-P715	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
TN1660	Ganoderic acid C1	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T4264	Takinib	Takinib is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
T3101	NQDI-1	NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
T9470	HPK1-IN-7	HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
T14055	5Z-7-Oxozeaenol	5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...
T26193	SKLB-163	SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
TN1445	Bisabolangelone	Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB si...
T5S1895	Norisoboldine	1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the...
T3350	Selonsertib	Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibroti...
T6760	APS-2-79 hydrochloride	APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required...
T12058	MK2-IN-3 hydrate	MK-2 Inhibitor III is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
T5190	GS-444217	GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87 nM).
T14988	CMPD1	CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor (apparent Ki (Kiapp): 330 nM).
T3836	Eudesmin	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 ...
T2382	Vemurafenib	Vemurafenib (PLX4032) is a novel and potent B-Raf (V600E) inhibitor (IC50: 31 nM).
T11438	GNE-1858	GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutan...
T16501	PF-3644022	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production...
T8911	Methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate	methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.
T4011	NCB-0846	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T13099	TC ASK 10	TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).
T16987	TAO Kinase inhibitor 1	TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinas...
T12979	BI-3406	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T9377	ASK1-IN-2	ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a...
T4442	MK2-IN-1 hydrochloride	MK2-IN-1 is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM)...
T9034	MK2-IN-3	MK2-IN-3 is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatme...
T8843	APS6-45	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
T8152	6-Demethoxytangeretin	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T7283	Sodium lauroyl-α-hydroxyethyl sulfonate	Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
TL0017	Aristolactam AIIIa	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
TN1441	Beta-Tocopherol	Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.
TN1338	7Beta-Hydroxycholesterol	7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells...
TN1269	3β-Methoxy-2,3-dihydrowithaferin A	3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
TN2123	Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside	Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
TN2081	Maohuoside A	Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
TN1806	Isotetrandrine	Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN1645	Flavokawain C	Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
TN2511	Britannilactone diacetate	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
T11942	MAP4K4-IN-3	MAP4K4-IN-3 may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
TN5100	Taspine	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN4956	Scandoside	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation...
TN4877	Quercetin 3,4'-dimethyl ether	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
TN4785	Picrasidine I	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-ÎºB and ROS generation followed by suppressing the gene ...
TQ0079	GNE-495	GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
TN4489	Manassantin A	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN4300	Isojacareubin	Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...