MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

Cat No.	product name
T0152	BosutinibHOT	Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.
T2382	VemurafenibHOT	Vemurafenib (PLX4032) is a novel and potent B-Raf (V600E) inhibitor (IC50: 31 nM).
T3101	NQDI-1	NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
T3410	Momordin Ic	Momordin Ic might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MA...
T3603	Sodium houttuyfonate	Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T3707	GNE-3511	GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T4221	PF-6260933	PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
T6760	APS-2-79	APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes require...
T4264	Takinib	Takinib is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
T5S1895	Norisoboldine	1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating th...
T3672	Nomilin	Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
T5483	DMX-5084	DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mic...
T5643	NG25	NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
TQ0079	GNE-495	GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
T3836	Eudesmin	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65...
T8152	6-Demethoxytangeretin	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
TN1441	Beta-Tocopherol	Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.
TN2081	Maohuoside A	Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
TN1269	3beta-Methoxy-2,3-dihydrowithaferin A	3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
TN1660	Ganoderic acid C1	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic...
TN2123	Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside	Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
TN1338	7Beta-Hydroxycholesterol	7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cell...
TN1445	Bisabolangelone	Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB ...
TN1645	Flavokawain C	Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cyc...
TN1806	Isotetrandrine	Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity o...
T12979	BI-3406	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 of 6 nM),with anticancer activit...
TL0017	Aristolactam AIIIa	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plat...
TN2511	1,6-O,O-Diacetylbritannilactone	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airw...
TN2694	2,3-Dihydro-3-methoxywithaferin A	2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects nor...
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps suc...
TN3144	6,4'-Dihydroxy-7-methoxyflavanone	6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
TN3397	Alpinumisoflavone	Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is ...
TN3587	Capillarisin	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
TN3691	Communic acid	Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmeti...
TN3805	Dehydrogeijerin	Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment o...
TN4038	Eupatolide	Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
TN4094	Gallocatechin gallate	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation thro...
TN4107	Ganoderic acid X	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN4114	Gardenin A	Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, b...
TN4194	Heliangin	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 ce...
TN4300	Isojacareubin	Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the stand...
TN4315	Isonardosinone	Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-ÎºB- and MAPK-mediated inflammatory pathways.
TN4489	Manassantin A	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
TN4785	Picrasidine I	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-ÎºB and ROS generation followed by suppressing the ge...
TN4877	Quercetin 3,4'-dimethyl ether	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl...
TN4956	Scandoside	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidat...
TN5100	Taspine	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of ...