P2X Receptor

The ATP-gated P2X receptor cation channel family, or simply P2X receptor family, consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.

Cat. No.	Product name	CAS No.	Purity
T6526	GW791343 trihydrochloride	309712-55-8	98%
T6526	GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
T16399	Opiranserin	1441000-45-8	98%
T16399	Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T9653	(E/Z)-Sivopixant	1640808-39-4	98%
T9653	(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.
T20731	Brilliant blue G-250	6104-58-1	98%
T20731	Brilliant Blue G is an antagonist of the P2X7 purinergic receptor.
T14920	CE-224535	724424-43-5	98%
T14920	CE-224535 is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.
T9786	Lu AF27139	2097117-06-9	98%
T9786	Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and ra...
T40045	Sivopixant	2414285-40-6	98%
T40045	Sivopixant (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect...
T10207	A 438079	899507-36-9	98%
T10207	A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T9833	Opiranserin hydrochloride	1440796-75-7	98%
T9833	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, ...
TP2226	BzATP triethylammonium salt	112898-15-4
TP2226	BzATP triethylammonium salt is a P2X7 receptor agonist.
T8333	Aurintricarboxylic acid	4431-00-9
T8333	Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
T37806	JNJ-55308942	2166558-11-6	100%
T37806	JNJ-55308942 is a selective and brain-penetrant antagonist of P2X7 functional with IC50s of 10 and 15 nM and Kis of 7.1 and 2.9 nM for hP2X7 and rP2X7, respectiv...
T7881	CTP disodium dihydrate	81012-87-5	100%
T7881	CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
T2806	Lappaconitine	32854-75-4	92.57%
T2806	Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
T7805	GW791343 dihydrochloride	1019779-04-4	95.57%
T7805	GW791343 dihydrochloride is a P2X7 allosteric modulator.
TQ0002	A-317491	475205-49-3	96.1%
TQ0002	A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T1131	Ivermectin	70288-86-7	97.74%
T1131	Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T8946	Indophagolin	1207660-00-1	97.84%
T8946	Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
T2087	AF-353	865305-30-2	97.95%
T2087	AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T4S0536	Bullatine A	1354-84-3	98%
T4S0536	1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treat...