Raf

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma. RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases.

Cat. No.	Product name	CAS No.	Purity
TN2114	Pseudoginsenoside Rh2	1370264-16-6	98%
TN2114	Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
T2074	Raf inhibitor 1	1093100-40-3	98%
T2074	B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor.
T12978	NSC-70220	4551-00-2	98%
T12978	SOS1-IN-1 is an inhibitor of SOS1.
T12556	PROTAC B-Raf degrader 1	2364367-27-9	98%
T12556	PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
T1931	6H05	1469338-01-9	98%
T1931	6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
T10567	BMS-214662	195987-41-8	98%
T10567	BMS-214662 is an effective and selective inhibitor of farnesyl transferase with potent antitumor activity (IC50: 1.35 nM).
T6003	GSK1904529A	1089283-49-7	98%
T6003	GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T6318	AZ 628	878739-06-1	98%
T6318	AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.
T8721	I-37	2359690-13-2	98%
T8721	I-37 is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.
TN4166	Griffipavixanthone	219649-95-3	98%
TN4166	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
T40284	B-Raf IN 2	2649372-20-1	98%
T40284	B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer.
T15804	LY2452473	1029692-15-6	98%
T15804	LY2452473 is an orally bioavailable and selective androgen receptor modulator.
T13406L	Zabofloxacin hydrochloride	623574-00-5	98%
T13406L	Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens inc...
T22272	Lifirafenib	1446090-79-4	98%
T22272	Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain...
T10599	BRAF inhibitor	918505-61-0	98%
T10599	BRAF inhibitor is an inhibitor of B-Raf extracted from patent WO/2011103196 A1 (Compound P-0850).
T11224	Rineterkib	1715025-32-3	98%
T11224	ERK-IN-1 is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is pa...
T19802	ZINC72115182	918504-27-5	98%
T19802	ZINC72115182 is a novel inhibitor of selective. It is the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer.
T6320	GDC-0879	905281-76-7	98%
T6320	GDC-0879 is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.
T6949	PLX7904	1393465-84-3	98%
T6949	PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melan...
T9755	MRTX0902	2654743-22-1	98%
T9755	MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.