Cat. No. | Product name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T79603 | 3,7-DMF | 20950-52-1 | 98% |
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3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By indu... | ||||
T79789 | DT-6 | 2414315-95-8 | 98% |
|
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing p... | ||||
T80562 | Nisevokitug | 2649854-92-0 | 98% |
Nisevokitug
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Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1]. | ||||
T80628 | Myristoyl tetrapeptide-12 | 959610-24-3 | 98% |
|
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2]. | ||||
T12923 | (Rac)-SIS3 free base | 1009104-85-1 | 98% |
|
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. | ||||
TN3753 | Dalbergioidin | 30368-42-4 | 98% |
|
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces... | ||||
T13137 | TGFβRI-IN-1 | 1950628-94-0 | 98% |
|
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively... | ||||
TN2165 | Rubrofusarin gentiobioside | 24577-90-0 | 99.91% |
|
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA bindi... | ||||
T2896 | Alantolactone | 546-43-0 | 99.91% |
|
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th... | ||||
T2273 | ITD-1 | 1099644-42-4 | 99.89% |
|
ITD-1 is a potent and highly selective TGFβ pathway inhibitor. | ||||
T2386 | Pirfenidone | 53179-13-8 | 99.88% |
|
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, ... | ||||
T1763 | SB 525334 | 356559-20-1 | 99.86% |
|
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM). | ||||
T2416 | BIX02189 | 1094614-85-3 | 99.86% |
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BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM. | ||||
T1944 | LDN-214117 | 1627503-67-6 | 99.85% |
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LDN-214117 is a potent and selective ALK2 inhibitor. | ||||
T2754 | Oxymatrine | 16837-52-8 | 99.84% |
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Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment a... | ||||
T4975 | SM 16 | 614749-78-9 | 99.81% |
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SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM). | ||||
T35348 | LDN-193189 2HCl | 1435934-00-1 | 99.78% |
|
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM... | ||||
T16708 | R-268712 | 879487-87-3 | 99.77% |
|
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ... | ||||
T1942 | DMH-1 | 1206711-16-1 | 99.7% |
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DMH-1 is a potent and selective BMP inhibitor. | ||||
T2048 | LY-364947 | 396129-53-6 | 99.65% |
|
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I. |