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TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79603 3,7-DMF 20950-52-1 98%
3,7-DMF
3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By indu...
T79789 DT-6 2414315-95-8 98%
DT-6
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing p...
T80562 Nisevokitug 2649854-92-0 98%
Nisevokitug
Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1].
T80628 Myristoyl tetrapeptide-12 959610-24-3 98%
Myristoyl tetrapeptide-12
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].
T12923 (Rac)-SIS3 free base 1009104-85-1 98%
(Rac)-SIS3 free base
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
TN3753 Dalbergioidin 30368-42-4 98%
Dalbergioidin
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
T13137 TGFβRI-IN-1 1950628-94-0 98%
TGFβRI-IN-1
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
TN2165 Rubrofusarin gentiobioside 24577-90-0 99.91%
Rubrofusarin gentiobioside
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA bindi...
T2896 Alantolactone 546-43-0 99.91%
Alantolactone
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th...
T2273 ITD-1 1099644-42-4 99.89%
ITD-1
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
T2386 Pirfenidone 53179-13-8 99.88%
Pirfenidone
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, ...
T1763 SB 525334 356559-20-1 99.86%
SB 525334
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T2416 BIX02189 1094614-85-3 99.86%
BIX02189
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T1944 LDN-214117 1627503-67-6 99.85%
LDN-214117
LDN-214117 is a potent and selective ALK2 inhibitor.
T2754 Oxymatrine 16837-52-8 99.84%
Oxymatrine
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment a...
T4975 SM 16 614749-78-9 99.81%
SM 16
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T35348 LDN-193189 2HCl 1435934-00-1 99.78%
LDN-193189 2HCl
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM...
T16708 R-268712 879487-87-3 99.77%
R-268712
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
T1942 DMH-1 1206711-16-1 99.7%
DMH-1
DMH-1 is a potent and selective BMP inhibitor.
T2048 LY-364947 396129-53-6 99.65%
LY-364947
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
3,7-DMF
T79603
3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By indu...
DT-6
T79789
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing p...
Nisevokitug
T80562
Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1].
Myristoyl tetrapeptide-12
T80628
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].
(Rac)-SIS3 free base
T12923
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
Dalbergioidin
TN3753
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
TGFβRI-IN-1
T13137
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
Rubrofusarin gentiobioside
TN2165
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA bindi...
Alantolactone
T2896
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th...
ITD-1
T2273
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
Pirfenidone
T2386
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, ...
SB 525334
T1763
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
BIX02189
T2416
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
LDN-214117
T1944
LDN-214117 is a potent and selective ALK2 inhibitor.
Oxymatrine
T2754
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment a...
SM 16
T4975
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
LDN-193189 2HCl
T35348
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM...
R-268712
T16708
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
DMH-1
T1942
DMH-1 is a potent and selective BMP inhibitor.
LY-364947
T2048
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
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TargetMol