label

UL-766 is a chemically stable fluorescent marker of the ureter.

4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label that exhibits significant activity against B. subtilis.

Tetrabenazine (Ro 1-9569) is a former antipsychotic drug used to treat various movement disorders. It inhibits neurotransmitter uptake into adrenergic storage vesicles and serves as a high-affinity label for the vesicle transport system.

SB 258585 is a selective 5-HT6 receptor antagonist.SB 258585 has a high affinity for individual receptor populations in cell lines with human recombinant 5-HT6 receptors.SB 258585 can be used to label both recombinant and natural 5-HT6 receptors, and can be used to assay cognitive enhancement and antipsychotic activity.

FMAU (2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine) is a thymine nucleoside analog with insertional activity on replicating DNA.FMAU can be used to label cells and track DNA synthesis.

FITC-Dextran (MW 60,000-76,000) is a fluorescein isothiocyanate (FITC)-labeled dextran fluorescent probe that is commonly used as a tracer molecule to label and track the action of cells or other biomaterials on semipermeable membranes.

Sphistin Synthetic Peptide (12-38, Fitc in N-Terminal-Fluorescently Labeled Peptide) represents truncated fragments of the parent peptide, characterized by an N-terminal fluorescent label (Fitc).

β-Amyloid (1-40), FAM-labeled, is a β-Amyloid (1-40) peptide tagged with a FAM fluorescent label, exhibiting an excitation wavelength (λ ex) of 492 nm and an emission wavelength (λ em) of 518 nm.

FAM-labeled Bid BH3 (80-99) is a biologically active peptide featuring a 5-FAM label at its N-terminus.

Melittin (C-term cysteine labeled), a variant of the toxic bee venom peptide melittin featuring a cysteine residue at its C-terminus, effectively induces hemolysis in isolated human red blood cells at both endosomal and extracellular pH levels, with EC50 values of 5 µM at pH 5.5 and 6 µM at pH 7.4. This compound is utilized in creating membrane-lytic polymers for the synthesis of polyplexes, facilitating plasmid delivery both in vitro and in vivo.

FITC-labeled ODN 1585 (sodium) effectively induces IFN and TNFα production and serves to assess CpG ODN cellular uptake and localization via confocal laser-scanning microscopy [excitation 495 nm, emission 520 nm] or flow cytometry.

FITC-labeled ODN TTAGGG (sodium) is an inhibitory oligonucleotide that antagonizes TLR9, AIM2, and cGAS, aiding in assessing CpG ODN cellular uptake and localization through confocal laser-scanning microscopy (excitation at 495 nm, emission at 520 nm) or flow cytometry.

Biotin-labeled ODN TTAGGG (sodium) is an inhibitory oligonucleotide (ODN) that antagonizes TLR9, AIM2, and cGAS, serving as a tool for assessing cellular uptake and localization of CpG ODN using biotin detection systems and light microscopy.

Endothelin 1 (swine, human), Alexa Fluor 488-labeled, is a synthetic peptide mirroring human and swine Endothelin 1, an endogenous vasoconstrictor, and is tagged with Alexa Fluor 488 for fluorescence, operating via two receptor types, ET A and ET B [1].

Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.

FITC-labeled ODN 2395 (sodium), a class C oligodeoxynucleotide and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and localization via confocal laser-scanning microscopy [excitation 495 nm, emission 520 nm] or flow cytometry.

Biotin-labeled ODN 1018 (sodium), a TLR-9 agonist oligodeoxynucleotide, is used to evaluate cellular uptake and localization of CpG ODNs via biotin detection systems and light microscopy.

Biotin-labeled ODN 2395 (sodium), a Class C oligodeoxynucleotide and TLR9 agonist, is used to evaluate cellular uptake and localization of CpG ODN via a biotin detection system integrated with light microscopy.

Biotin-labeled Agatolimod (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, facilitates the assessment of cellular uptake and localization of CpG ODNs through a biotin detection system with light microscopy.

Biotin-labeled ODN 1826 (sodium), a class B CpG oligodeoxynucleotide (ODN), functions as a TLR9 agonist and enables the evaluation of CpG ODN cellular uptake and localization using biotin detection systems and light microscopy.

FITC-labeled ODN 1826 (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, enables the evaluation of CpG ODN cellular uptake and localization via confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

FITC-labeled ODN 1668 (sodium), a class B CpG oligodeoxynucleotide (ODN), functions as a TLR9 agonist and is used to assess the cellular uptake and localization of CpG ODNs via confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) and flow cytometry.

Biotin-labeled ODN 2216 (sodium) acts as a specific agonist for human TLR9 (toll-like receptor 9), enabling the evaluation of CpG ODN cellular uptake and localization via a biotin detection system coupled with light microscopy.

[18F]-Labeled L-dopa precursor is used in the synthesis of 18F-labeled L-dopa[1].

β-Amyloid (1-40), FAM-labeled TFA, is a FAM fluorescently-labeled β-Amyloid (1-40) peptide (λ ex = 492 nm and λ em = 518 nm) [1].

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, is one of three mammalian natriuretic peptides (NPs) with endocrine effects on fluid homeostasis and blood pressure, holding promise for cardiovascular disease research.

FITC-labeled ODN 2216 (sodium), a specific agonist for human toll-like receptor 9 (TLR9), facilitates the assessment of CpG ODN cellular uptake and localization through confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

FITC-labeled Agatolimod (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, enables the evaluation of CpG ODN cellular uptake and localization using confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

TAT (47-57), FAM-labeled, is a cell-penetrating peptide (CPP) with significant potential for intracellular drug delivery research [1].

FITC-labeled Tominersen is Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

FITC-labeled ODN 1018 (sodium), a TLR-9 agonist oligodeoxynucleotide, enables the evaluation of CpG ODN cellular uptake and localization via confocal laser-scanning microscopy [excitation 495 nm, emission 520 nm] or flow cytometry.

Biotin-labeled ODN 1668 (sodium), a class B CpG oligodeoxynucleotide (ODN) and TLR9 agonist, enables the evaluation of cellular uptake and localization of CpG ODNs using a biotin detection system and light microscopy.

Biotin-labeled ODN 1585 (sodium) effectively induces IFN and TNFα production, and enables assessment of CpG ODN cellular uptake and localization via biotin system detection and light microscopy analysis.

Biotin-labeled ODN 2088 (sodium) is a potent inhibitor of TLR3, TLR7, and TLR9, used to evaluate cellular uptake and localization of CpG ODN via a biotin detection system in conjunction with light microscopy.

FITC-labeled ODN 2088 (sodium) is a potent inhibitor of TLR3, TLR7, and TLR9, used to assess CpG ODN cellular uptake and localization via confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

Biotin-labeled Hyaluronan-binding Peptide is a biologically active peptide conjugated with biotin via a C-terminal GGGSK linker. It interacts with the non-sulfated glycosaminoglycan hyaluronan (HA), prominent in the extracellular matrix and on cellular surfaces, involved in processes such as fertilization, embryonic development, wound healing, angiogenesis, leukocyte migration, and cancer metastasis. The peptide impedes HA's interaction with CD44 receptors and curtails T cell proliferation.

The compound, Biotin-labeled Syk Kinase Peptide Substrate, is a peptide substrate of Syk kinase that is labeled with biotin.

Elabela(19-32) TFA, an effective fragment of ELABELA (ELA), selectively engages with the apelin receptor (APJ). This compound initiates G αi1 and β-arrestin-2 signaling, demonstrating EC50 values of 8.6 nM and 166 nM, respectively. It facilitates receptor internalization, lowers arterial pressure, and has a positive inotropic impact on cardiac function [1].

BAD (103-127) (human), a FAM-labeled 25-mer peptide derived from the BH3 domain of human BAD, antagonizes the function of Bcl-xL [1].

Bak BH3 (72-87), TAMRA-labeled, is a bioactive peptide.

Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.

MSBN is a highly selective fluorescent probe for mercaptans that can selectively image mercaptans in living cells and specifically label protein mercaptans by switching on the signal to identify various reversible protein mercaptans modifications.

Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is a novel fluorescence label utilized in the determination of fatty acids via HPLC or TLC.

DBCO-S-S-PEG3-biotin is a cleavable reagent for the introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved with reducing agents such as DTT, BME, and TCEP to remove the biotin label. PEG linkers can also be used in the synthesis of PROTACs.

Tetrabenazine Racemate (Rubigen) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2). Tetrabenazine Racemate blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high-affinity label for the vesicle transport system.

CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity. It inhibits farnesylation of recombinant human H-Ras (IC50=0.57 ng mL) and K-Ras (IC50=46 ng mL)[1]. In 3T3 H-ras (61L)-transfected cell lines, CP-609754 exhibits a slow on off rate, inhibiting mutant H-Ras farnesylation with an IC50 of 1.72 ng mL[1]. The compound is competitive for the prenyl acceptor (H-Ras protein) and noncompetitive for the prenyl donor farnesyl PPI, selectively inhibiting farnesylation of both H- and K-Ras proteins in 3T3 transfectants[1]. In vivo, CP-609754 shows antitumor activity against 3T3 H-ras (61L) tumors, with tumor regression achieved at 100 mg kg twice daily and an ED50 for tumor growth inhibition at 28 mg kg[1]. Continuous i.p. infusion of CP-609754 inhibits tumor growth by over 50% and reduces tumor farnesyltransferase activity by over 30% when plasma concentration is maintained above 118 ng mL[1]. [1]. Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35.

FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally, FLTX1 demonstrates strong antiestrogenic activity in breast cancer cells, resembling the potent antiestrogenic properties of Tamoxifen. Notably, FLTX1 does not exhibit any estrogenic agonistic effect on the uterus.

EE 581 can be used to label the somatostatin receptor.

BS2G crosslinker (Bis[Sulfosuccinimidyl] glutarate) is an amine reactive, water-soluble, isofunctional protein crosslinker. The molecule is impenetrable to cell membranes and can be used to label cell surface proteins.

4-carboxy TEMPO is a nitroxide and spin label. Nitroxides such as 4-carboxy TEMPO react with reactive oxygen species (ROS) and can be used with electron spin resonance (ESR) spectroscopy to monitor ROS production in vivo., It has also been used to study flavin-photosensitized damage in inner mitochondrial membranes.