T0740 |
Metformin hydrochlorideHOT |
Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells includi...
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T0800 |
Antrapurol |
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK. |
T1453 |
Phenformin hydrochloride |
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. |
T1477 |
AICAR (Acadesine) |
Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating oth...
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T1977 |
Dorsomorphin |
Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin. |
T2133 |
Adenosine 5'-monophosphate |
Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine. |
T2374 |
HTH-01-015 |
HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM). |
T2468 |
A 769662 |
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM). |
T3676 |
Sesamol |
Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upr...
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T3863 |
Chikusetsusaponin IVa |
Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed int...
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T6146 |
Dorsomorphin dihydrochlorideHOT |
Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases. |
T6291 |
WZ4003 |
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 oth...
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T4427 |
PF-06409577 |
PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1). |
T3S0195 |
Nootkatone |
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent...
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T2S0410 |
Euphorbia factor L1 |
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T2854 |
Forsythin |
Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expres...
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T2978 |
Mogroside V |
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edem...
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T5187 |
MK-3903 |
MK-3903 is a potent and selective AMPK activator (EC50: 8 nM). |
T5497 |
AMAROGENTIN |
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell...
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T5576 |
YKL-06-061 |
YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively. |
T5993 |
ARN-3236 |
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectivel...
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T7362 |
O-304 |
O-304 is a pan-activator of AMP-activated protein kinase (AMPK). |
T7327 |
7-Methoxyisoflavone |
7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK). |
TQ0028 |
EX229 |
EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively. |
T4599 |
HG-9-91-01 |
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respecti...
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TN1140 |
Onjisaponin B |
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±...
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TN1440 |
Beta-Hydroxyisovalerylshikonin |
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in...
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TN1499 |
Cimiracemoside C |
The Cimicifuga racemosa extract Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and cimiracemoside C) can reduce significantly body weight, ...
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TN1731 |
Hernandezine |
Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines). |
TN1868 |
Ligupurpuroside A |
Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L. |
TN1870 |
Ligupurpuroside C |
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L. |
TN1911 |
Marein |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation ...
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TN1100 |
Nepodin |
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
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TN1189 |
13-Methylberberine |
13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug |
TN1836 |
Kudinoside D |
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway. |
TN1990 |
Norathyriol |
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. |
TN1670 |
Ganodermanondiol |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
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TN2097 |
Pomolic acid |
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-media...
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T10105 |
3α-Hydroxymogrol |
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation. |
T14149 |
AICAR phosphate |
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
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T10312 |
Ampkinone |
Ampkinone is an indirect AMPK activator. |
T8476 |
RSVA 405 |
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor |
T11570 |
HL271 |
HL271 attenuates aging-associated cognitive impairment. HL271, a chemical derivative of metformin , is a potent AMPK activator that increases AMPK phosphoryl...
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T10789 |
Chitosan oligosaccharide |
Chitosan oligosaccharide, an oligomer of β-(1→4)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways. |
T8432 |
ASP4132 |
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity. |
T13371 |
YM-53601 free base |
YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents. |
T16113 |
ML753286 |
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP ...
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T16166 |
N-[(4-Aminophenyl)methyl]adenosine |
N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase). |
T16240 |
N,N'-Diacetyl-L-cystine |
N,N'-diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effec...
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T3904 |
Gomisin J |
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic ...
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T22460 |
XMD-17-51 |
XMD-17-51 is a potent and highly selective NUAK1 inhibitor. |
T2S0501 |
Ilexgenin A |
Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib...
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T2S0820 |
Karanjin |
Karanjin is a potent Volume-regulated anion channels(VRACs) current inhibitor, the VRAC inhibition might be responsible for its anti-angiogenic effects. Karanji...
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T3S0137 |
Bavachalcone |
Bavachalcone has antibiotic or anticancer activities, it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect th...
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TL0014 |
Pinusolide |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
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TN3042 |
4-Hydroxycinnamamide |
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. |
TN4382 |
Kazinol A |
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M a...
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TN5013 |
Shizukaol D |
Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may b...
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