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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
Cat No. product name
T41162 ZLN 024 hydrochloride ZLN 024 hydrochloride 是一种 AMPK 变构激活剂,可刺激无活性的 α1 亚基截短 α1 (1-394) 和 α1 (1-335),但不刺激 α1 (1-312)。
T9219 WH-4-025 WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
T8740 COH-SR4 SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inh...
T2854 Phillyrin Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the express...
T19500 Palmitelaidic Acid Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
T3676 Sesamol Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upreg...
T0858 Flufenamic acid Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorder...
TN1100 Nepodin Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
T2S0820 Karanjin Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Ka...
T3220 Euphorbiasteroid Euphorbiasteroid (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
T6129 GSK-1070916 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
T2133 Adenosine monophosphate Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
T8526 Metformin Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorptio...
T13411 ZLN024 ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, ...
T1020 Doxorubicin hydrochloride Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
T6285 GSK-690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
T5497 AMAROGENTIN Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell ...
T6854 GSK621 GSK621 is a specific and potent AMPK activator.
T7955 EB-3D EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
T1453 Phenformin hydrochloride Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
TN1440 Beta-Hydroxyisovalerylshikonin Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
T0800 Danthron Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T3546 STO-609 STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL)....
T0740 Metformin hydrochloride Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including ...
T2750 Ginkgolide C Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
T3625 Bempedoic acid ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C...
T2746 Sophocarpine monohydrate Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T16156 MT 63-78 MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathway...
T1477 AICAR Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...
T19661 8-Chloroadenosine 8-Chloroadenosine is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is assoc...
T8476 RSVA405 RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T1977 Dorsomorphin Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
TN1990 Norathyriol Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T4S0800 Demethyleneberberine Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T6920 ON123300 ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
T6146 Dorsomorphin dihydrochloride Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
T3881 Vaccarin Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
TN1911 Marein Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
T3889 Platycodin D Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
T11947 MARK4 inhibitor 1 MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
T0853L Adenosine 5'-monophosphate monohydrate Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
T5552 Methyl cinnamate Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
T22460 XMD-17-51 XMD-17-51 is a potent and highly selective NUAK1 inhibitor.
T2374 HTH-01-015 HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
T2468 A-769662 A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T2978 Mogroside V Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
T20029 Buformin hydrochloride Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointe...
TN1828 Kahweol Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
TN1836 Kudinoside D Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
TN1870 Ligupurpuroside C Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
ZLN 024 hydrochloride
T41162
ZLN 024 hydrochloride 是一种 AMPK 变构激活剂,可刺激无活性的 α1 亚基截短 α1 (1-394) 和 α1 (1-335),但不刺激 α1 (1-312)。
WH-4-025
T9219
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
COH-SR4
T8740
SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inh...
Phillyrin
T2854
Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the express...
Palmitelaidic Acid
T19500
Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
Sesamol
T3676
Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upreg...
Flufenamic acid
T0858
Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorder...
Nepodin
TN1100
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
Karanjin
T2S0820
Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Ka...
Euphorbiasteroid
T3220
Euphorbiasteroid (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
GSK-1070916
T6129
GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
Adenosine monophosphate
T2133
Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
Metformin
T8526
Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorptio...
ZLN024
T13411
ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µ...
Doxorubicin hydrochloride
T1020
Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
GSK-690693
T6285
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
AMAROGENTIN
T5497
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell ...
GSK621
T6854
GSK621 is a specific and potent AMPK activator.
EB-3D
T7955
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
Phenformin hydrochloride
T1453
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
Beta-Hydroxyisovalerylshikonin
TN1440
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
Danthron
T0800
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
STO-609
T3546
STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL...
Metformin hydrochloride
T0740
Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including ...
Ginkgolide C
T2750
Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
Bempedoic acid
T3625
ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C...
Sophocarpine monohydrate
T2746
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
MT 63-78
T16156
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathwa...
AICAR
T1477
Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...
8-Chloroadenosine
T19661
8-Chloroadenosine is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is assoc...
RSVA405
T8476
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
Dorsomorphin
T1977
Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
Norathyriol
TN1990
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
Demethyleneberberine
T4S0800
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
ON123300
T6920
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
Dorsomorphin dihydrochloride
T6146
Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
Vaccarin
T3881
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
Marein
TN1911
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
Platycodin D
T3889
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat periton...
MARK4 inhibitor 1
T11947
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
Adenosine 5'-monophosphate monohydrate
T0853L
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
Methyl cinnamate
T5552
Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
XMD-17-51
T22460
XMD-17-51 is a potent and highly selective NUAK1 inhibitor.
HTH-01-015
T2374
HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
A-769662
T2468
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
Mogroside V
T2978
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
Buformin hydrochloride
T20029
Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointe...
Kahweol
TN1828
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
Kudinoside D
TN1836
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
Ligupurpuroside C
TN1870
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
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