T0740 |
Metformin hydrochlorideHOT |
Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including...
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T0800 |
Antrapurol |
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK. |
T1453 |
Phenformin hydrochloride |
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. |
T1477 |
AICAR (Acadesine) |
Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating oth...
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T1977 |
Dorsomorphin |
Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin. |
T2133 |
Adenosine 5'-monophosphate |
Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine. |
T2374 |
HTH-01-015 |
HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM). |
T2468 |
A 769662 |
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM). |
T3676 |
Sesamol |
Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upre...
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T3863 |
Chikusetsusaponin IVa |
Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into...
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T6129 |
GSK1070916 |
GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related...
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T6146 |
Dorsomorphin dihydrochlorideHOT |
Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases. |
T6291 |
WZ4003 |
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 oth...
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T6854 |
GSK621 |
GSK621 is a specific and potent AMPK activator. |
T4427 |
PF06409577 |
PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1). |
T3S0195 |
Nootkatone |
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent ...
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T2S0410 |
Euphorbia factor L1 |
1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 a...
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T2854 |
Forsythin |
Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expres...
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T2978 |
Mogroside V |
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edem...
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T5187 |
MK3903 |
MK-3903 is a potent and selective AMPK activator (EC50: 8 nM). |
T5497 |
AMAROGENTIN |
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell...
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T5576 |
YKL-06-061 |
YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively. |
T5993 |
ARN-3236 |
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectivel...
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T7362 |
O-304 |
O-304 is a pan-activator of AMP-activated protein kinase (AMPK). |
T7327 |
7-Methoxyisoflavone |
7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK). |
TQ0028 |
EX229 |
EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively. |
T4599 |
HG-9-91-01 |
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respect...
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TN1140 |
Onjisaponin B |
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±...
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TN1440 |
Beta-Hydroxyisovalerylshikonin |
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in...
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TN1499 |
Cimiracemoside C |
The Cimicifuga racemosa extract Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and cimiracemoside C) can reduce significantly body weight, ...
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TN1731 |
Hernandezine |
Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines). |
TN1868 |
Ligupurpuroside A |
Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L. |
TN1870 |
Ligupurpuroside C |
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L. |
TN1911 |
Marein |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation ...
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TN1100 |
Nepodin |
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
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TN1189 |
13-Methylberberine |
13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug |
TN1836 |
Kudinoside D |
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway. |
TN1990 |
Norathyriol |
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. |
TN1670 |
Ganodermanondiol |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
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TN2097 |
Pomolic acid |
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-media...
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T10105 |
3α-Hydroxymogrol |
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation. |
T14149 |
AICAR phosphate |
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
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T10312 |
Ampkinone |
Ampkinone is an indirect AMPK activator. |
T8476 |
RSVA 405 |
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor |
T11570 |
HL271 |
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment. |
T10789 |
Chitosan oligosaccharide |
Chitosan oligosaccharide, an oligomer of β-(1→4)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways. |
T8432 |
ASP4132 |
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity. |
T13371 |
YM-53601 free base |
YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents. |
T16113 |
ML753286 |
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP ...
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T16166 |
N-[(4-Aminophenyl)methyl]adenosine |
N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase). |
T16240 |
N,N'-Diacetyl-L-cystine |
N,N'-diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effec...
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T3904 |
Gomisin J |
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic ...
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T22460 |
XMD-17-51 |
XMD-17-51 is a potent and highly selective NUAK1 inhibitor. |
T2S0501 |
Ilexgenin A |
Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr |
T2S0820 |
Karanjin |
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T3S0137 |
Bavachalcone |
Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L. it may be useful as a therapeutic drug for bone resorption-associated disease...
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TL0014 |
Pinusolide |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
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TN3042 |
4-Hydroxycinnamamide |
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. |
TN4382 |
Kazinol A |
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M a...
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TN5013 |
Shizukaol D |
Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may b...
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T13265 |
Urolithin B |
Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enh...
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T3405 |
6-Gingerol |
6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the b...
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T2750 |
Ginkgolide C |
Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body. |
T2746 |
Sophocarpine monohydrate |
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
T16156 |
MT 63-78 |
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathw...
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T16099 |
MK8722 |
MK8722 is an effective and systemic activator of pan-AMPK. |
T8526 |
Metformin |
Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorpti...
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T5162 |
MRT67307 HCl (1190378-57-4(free base)) |
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively). |
T0853L |
Adenosine 5'-monophosphate monohydrate |
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucle...
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T8929 |
BC1618 |
BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improve...
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