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Immunology / Inflammation NOS

NOS

Nitric oxide synthases(NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS).
Cat No. product name
T0344 Miconazole Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
T0358 Aminoguanidine hydrochloride Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
T0947 Dexamethason acetate Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bin...
T1076 DexamethasoneHOT Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.
T2738 Dehydroandrographolide Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
T2876 Flavone Flavons have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body.
T3408 Syringin Syringin is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.
T3491 1400W dihydrochloride 1400 W is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
T3884 Neoandrographolide Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage. Neoandrographolide has anti-inflammatory ef...
T6570 L-NAME hydrochloride L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM,15 nM, and 39 nM, for iNOS (mouse) ,nNOS (bovine) , and eNOS (huma...
T5S0281 Tubuloside A Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes...
T4S0800 Demethyleneberberine Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either...
T4953 Neotuberostemonine Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM...
T5681 ETHYL CAFFEATE ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor,and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
T5676 (Z)-SU4312 (Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
T5688 Micheliolide Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T5807 Stylopine hydrochloride Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
T7206 2-Iminobiotin 2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of...
T7191 Diphenyleneiodonium chloride Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bac...
T2351 TAK875 TAK875 is a potent, selective and orally bioavailable GPR40 agonist.
T7474 7-Nitroindazole 7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1562 Dehydromiltirone Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting N...
TN2091 Polygalacin D Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
TN2232 Soyasaponin Ab Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of...
TN2327 Zedoarondiol Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPK...
TN1058 Pelargonidin chloride Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels ...
TN1109 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264....
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under act...
TN1171 1-Dehydro-6-gingerdione 1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TN1222 23-epi-26-Deoxyactein 23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. ...
TN1238 3,4-O-Isopropylidene shikimic acid 3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimen...
TN1516 Cnidicin Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 m...
TN1576 Diallyl disulfide Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
TN1598 Dunnianol Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold ...
TN1623 Escin IIB Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and...
TN1650 Friedelin Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
TN1949 Moracin C Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
TN1962 Myricetin 3-O-galactoside Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral in...
TN2095 Pomiferin Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has ...
TN1006 Tirucallol Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.
TN1086 Dehydroeburicoic acid Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
TN1118 Tormentic acid Tormentic acid has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,
TN1406 Aromadendrin Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear t...
TN1465 Cannabigerol Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also...
TN1524 Continentalic acid Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
TN1599 Eburicoic acid Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme...
TN1622 Ermanin Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent ac...
TN1834 Kobusin Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflamma...
TN1890 Lupeol acetate Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the c...
Miconazole
T0344CAS 22916-47-8
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
Aminoguanidine hydrochloride
T0358CAS 1937-19-5
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
Dexamethason acetate
T0947CAS 1177-87-3
Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bin...
Dexamethasone HOT
T1076CAS 50-02-2
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.
Dehydroandrographolide
T2738CAS 134418-28-3
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
Flavone
T2876CAS 525-82-6
Flavons have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body.
Syringin
T3408CAS 118-34-3
Syringin is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.
1400W dihydrochloride
T3491CAS 214358-33-5
1400 W is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
Neoandrographolide
T3884CAS 27215-14-1
Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage. Neoandrographolide has anti-inflammatory ef...
L-NAME hydrochloride
T6570CAS 51298-62-5
L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM,15 nM, and 39 nM, for iNOS (mouse) ,nNOS (bovine) , and eNOS (huma...
Tubuloside A
T5S0281CAS 112516-05-9
Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes...
Demethyleneberberine
T4S0800CAS 25459-91-0
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either...
Neotuberostemonine
T4953CAS 143120-46-1
Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM...
ETHYL CAFFEATE
T5681CAS 102-37-4
ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor,and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
(Z)-SU4312
T5676CAS 90828-16-3
(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
Micheliolide
T5688CAS 68370-47-8
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
Stylopine hydrochloride
T5807CAS 96087-21-7
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
2-Iminobiotin
T7206CAS 13395-35-2
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of...
Diphenyleneiodonium chloride
T7191CAS 4673-26-1
Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bac...
TAK875
T2351CAS 1000413-72-8
TAK875 is a potent, selective and orally bioavailable GPR40 agonist.
7-Nitroindazole
T7474CAS 2942-42-9
7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
Procyanidin B3
TN1150CAS 23567-23-9
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
Dehydromiltirone
TN1562CAS 116064-77-8
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting N...
Polygalacin D
TN2091CAS 66663-91-0
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
Soyasaponin Ab
TN2232CAS 118194-13-1
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of...
Zedoarondiol
TN2327CAS 98644-24-7
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPK...
Pelargonidin chloride
TN1058CAS 134-04-3
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels ...
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
TN1109CAS 168293-14-9
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264....
Schisandrone
TN1116CAS 98619-25-1
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under act...
1-Dehydro-6-gingerdione
TN1171CAS 76060-35-0
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
23-epi-26-Deoxyactein
TN1222CAS 264624-38-6
23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. ...
3,4-O-Isopropylidene shikimic acid
TN1238CAS 183075-03-8
3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimen...
Cnidicin
TN1516CAS 14348-21-1
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 m...
Diallyl disulfide
TN1576CAS 2179-57-9
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
Dunnianol
TN1598CAS 139726-29-7
Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold ...
Escin IIB
TN1623CAS 158800-83-0
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and...
Friedelin
TN1650CAS 559-74-0
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
Moracin C
TN1949CAS 69120-06-5
Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
Myricetin 3-O-galactoside
TN1962CAS 15648-86-9
Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral in...
Pomiferin
TN2095CAS 572-03-2
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has ...
Tirucallol
TN1006CAS 514-46-5
Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.
Dehydroeburicoic acid
TN1086CAS 6879-05-6
Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
Tormentic acid
TN1118CAS 13850-16-3
Tormentic acid has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,
Aromadendrin
TN1406CAS 480-20-6
Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear t...
Cannabigerol
TN1465CAS 25654-31-3
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also...
Continentalic acid
TN1524CAS 19889-23-7
Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
Eburicoic acid
TN1599CAS 560-66-7
Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme...
Ermanin
TN1622CAS 20869-95-8
Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent ac...
Kobusin
TN1834CAS 36150-23-9
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflamma...
Lupeol acetate
TN1890CAS 1617-68-1
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the c...