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NOS

Nitric oxide synthases(NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN4383 Kazinol U 1238116-48-7 98%
Kazinol U
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
T3P2855 Chamigrenal 19912-84-6
Chamigrenal
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO producti...
TN1086 Dehydrotrametenolic acid 6879-05-6
Dehydrotrametenolic acid
Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
TN5192 Tuberosin 41347-45-9 98%
Tuberosin
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
TN5248 Voleneol 70389-88-7 98%
Voleneol
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependent...
TN3366 Ailanthoidol 156398-61-7 98%
Ailanthoidol
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
TN3635 Chlojaponilactone B 1449382-91-5 98%
Chlojaponilactone B
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN5164 Trans-Hinokiresinol 17676-24-3 98%
trans-Hinokiresinol
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
TN4038 Eupatolide 6750-25-0 98%
Eupatolide
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN3587 Capillarisin 56365-38-9 98%
Capillarisin
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN2095 Pomiferin 572-03-2 98%
Pomiferin
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
TN4633 Neocryptotanshinone II 27468-20-8 98%
Neocryptotanshinone II
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
T16830 S-MTC 156719-41-4 98%
S-MTC
S-MTC is a selective inhibitor of type I nitric oxide synthase.
TN1890 Lupeol acetate 1617-68-1 98%
Lupeol acetate
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
TN1171 6-Dehydrogingerdione 76060-35-0 98%
6-Dehydrogingerdione
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TN1623 Escin IIB 158800-83-0 98%
Escin IIB
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and ...
TN5186 Triptoquinone A 142950-86-5 98%
Triptoquinone A
Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory...
T13628 Curvularin 10140-70-2 98%
Curvularin
Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iN...
TN5011 Shizukaol B 142279-40-1 98%
Shizukaol B
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
Kazinol U
TN4383
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
Chamigrenal
T3P2855
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO producti...
Dehydrotrametenolic acid
TN1086
Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
Tuberosin
TN5192
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner....
Voleneol
TN5248
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependent...
Ailanthoidol
TN3366
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
Chlojaponilactone B
TN3635
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
trans-Hinokiresinol
TN5164
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Pomiferin
TN2095
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
Neocryptotanshinone II
TN4633
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
S-MTC
T16830
S-MTC is a selective inhibitor of type I nitric oxide synthase.
Lupeol acetate
TN1890
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
6-Dehydrogingerdione
TN1171
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
Escin IIB
TN1623
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and ...
Triptoquinone A
TN5186
Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory...
Curvularin
T13628
Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iN...
Shizukaol B
TN5011
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
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TargetMol