thiol

Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.

Cysteine thiol probe (Methyl (4-bromobenzoyl)-L-cysteinate) is a chemoselective thiol probe for detection of electrophilic metabolites

5-Methyl-1,3,4-thiadiazole-2-thiol is a useful organic compound for research related to life sciences. The catalog number is T66917 and the CAS number is 29490-19-5.

Thiol-PEG10-alcohol is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG8-acid, a PEG-based linker for PROTACs, facilitates the conjugation of two essential ligands necessary for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Thiol-PEG3-Boc, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG-thiol (MW 2000) is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG-thiol (MW 10000) is a PEG-based linker for PROTACs that joins two critical ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG3-phosphonic acid ethyl ester, a PEG-based linker, serves as a valuable component in the synthesis of PROTACs[1].

m-PEG-thiol (MW 5000) is a PEG-based linker used in PROTACs, facilitating the conjugation of essential ligands necessary for PROTAC molecule formation, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

VH032 thiol (VHL ligand 6) is a VHL ligand that connects via a linker to the pan-BET inhibitor JQ1 to form a PROTAC[1] compound.

Boc-Aminooxy-PEG3-thiol, a polyethylene glycol (PEG)-based PROTAC linker, is used in the synthesis of PROTACs[1].

Thiol-C9-PEG5 is a PEG-based linker essential for PROTACs, facilitating the connection of two crucial ligands to enable selective protein degradation through the ubiquitin-proteasome system within cells.

Thiol-PEG12-alcohol is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras], connecting two essential ligands necessary for PROTAC molecule formation and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Thiol-PEG3-acid, a PEG-based linker for PROTACs, facilitates the connection of two essential ligands to form PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Amine-PEG-thiol (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker primarily used for the synthesis of PROTACs[1].

Thiol-PEG5-alcohol, a PEG-based linker for PROTACs, connects two essential ligands crucial for PROTAC molecule formation and facilitates selective protein degradation via the ubiquitin-proteasome system within cells.

DSPE-Thiol, a thiol-capped phospholipid, demonstrates selective reactivity with maleimide and is employed in the synthesis of phospholipid dimers [1].

Thiol-PEG4-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Thiol-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derivative frequently used in the construction of PROTACs, bifunctional compounds designed for targeted protein degradation [1].

Thiol-C9-PEG4 is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-C9-PEG7 is a PEG-based linker for PROTACs, which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG2-t-butyl ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

m-PEG6-thiol, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media.

Thiol-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG-CH2COOH (MW 3400) is a Polyethylene Glycol (PEG) derivative used as a PROTAC linker for PROTAC synthesis[1].

Thiol-PEG8-alcohol is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG3-phosphonic acid is a PEG-based linker compound used in PROTAC synthesis [1].

Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Aminooxy-PEG3-thiol HCl salt is an Aminooxy PEG Linker. PEG Linkers may be useful in the development of antibody-drug conjugates and drug delivery methods.

Thiol-C10-amide-PEG8, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG12-Thiol is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG8-thiol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Thiol-PEG6-alcohol is a PEG-based linker for PROTACs, joining two essential ligands for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

t-Boc-N-amido-PEG3-thiol is a PEG derivative containing a Boc-protected amino group and a thiol group.

VH 101, a thiol (compound 20), serves as a VHL ligand essential for PROTAC synthesis [1].

Thiol-PEG3-alcohol is a PEG derivative containing a hydroxyl group and a thiol group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Thiol-PEG6-acid is a PEG-based linker for PROTACs, joining two essential ligands vital for PROTAC molecule formation. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG4-Boc is a PEG-based linker for PROTACs that connects two key ligands, essential for forming PROTAC molecules, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker used in PROTAC synthesis [1].

Thiol-C9-PEG4-acid is a PEG-based linker for PROTACs that facilitates the conjugation of two essential ligands, playing a crucial role in the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

4,5-Dihydrothiazole-2-thiol is a useful organic compound for research related to life sciences. The catalog number is T67417 and the CAS number is 96-53-7.

Thiol-PEG5-acid is a PEG-based linker for PROTACs that connects two essential ligands indispensable for the formation of PROTAC molecules, facilitating selective protein degradation using the ubiquitin-proteasome system within cells.

m-PEG-thiol (MW 20000) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Thiol-PEG9-alcohol, a PEG-based linker for PROTACs, joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.

m-PEG7-thiol, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by joining two essential ligands. This linker promotes selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Thiol-PEG12-acid, a PEG-based linker for PROTACs, joins two essential ligands necessary for PROTAC molecule formation and facilitates selective protein degradation through the ubiquitin-proteasome system within cells.

VH032-thiol-C6-NH2, also known as VHL Ligand-Linker Conjugates 14, is a synthesized compound that functions as an E3 ligase ligand-linker conjugate. This compound combines the VH032 based VHL ligand with a linker commonly utilized in PROTAC technology.