vitamin a

Vitamin A-d4 is a deuterated compound of Vitamin A. Vitamin A has a CAS number of 68-26-8. Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

25-Hydroxy vitamin D2-d3 is a deuterated compound of 25-Hydroxy vitamin D2.

25-Hydroxy vitamin D3-d3 is a deuterated compound of 25-Hydroxy vitamin D3.

α-Vitamin E-d6 is a deuterated compound of α-Vitamin E. Vitamin K1 has a CAS number of 59-02-9. α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E that is also an antioxidant.

Vitamin K1-d7 is a deuterated compound of Vitamin K1.

Vitamin A-d5 Acetate is a deuterated compound of Vitamin A Acetate. Vitamin A Acetate has a CAS number of 127-47-9. Vitamin A is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most important.

Vitamin K1-d4 is a deuterated compound of Vitamin K1. Vitamin K1 has a CAS number of 84-80-0. Vitamin K1 (Phylloquinone) is a naturally-occurring vitamin. Vitamin K1 is essential for blood clotting, bone and vascular metabolism.

Vitamin K3-d8 is a deuterated compound of Vitamin K3.

Vitamin D3-d3 is a deuterated compound of Vitamin D3.

Vitamin K3-d3 is a deuterated compound of Vitamin K3. Vitamin K3 has a CAS number of 58-27-5. Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Vitamin B1 Pyrophosphate-d3 is a deuterated compound of Vitamin B1 Pyrophosphate.

ALK-001 is a vitamin A analog, which may be used to treat Stargardt disease.

Vitamin B12-d6 is a deuterated compound of Vitamin B12.Vitamin B12 has a CAS number of 13408-78-1.

Retinoic acid-d5 (Vitamin A acid-d5) is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 17 nM for PPARβ/δ. Retinoic acid, a metabolite of vitamin A, plays an important role in cell growth, differentiation and organ development. Retinoic acid acts by activating retinoic acid receptor alpha as an inhibitor of the transcription factor Nrf2.

Vitamin-d4-d5 is a deuterated compound of Vitamin. Vitamin has a CAS number of 511-28-4. Vitamin D4 is the active Vitamin D analog.

Vitamin B12-13C7 is the 13C labeled compound of Vitamin B12. Vitamin B12 has a CAS number of 13408-78-1.

Vitamin-d4-d3 is a deuterated compound of Vitamin. Vitamin has a CAS number of 511-28-4. Vitamin D4 is the active Vitamin D analog.

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.

Phenindione D5 is deuterium labeled Phenindione, which functions as a Vitamin K antagonist.

Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.

Methylcobalamin-13C-d3 is the 13C and deuterated compound of Methylcobalamin. Methylcobalamin has a CAS number of 13422-55-4. Methylcobalamin is one active form of vitamin B12 which can directly participate in homocysteine metabolism. It is used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis.

MK7-d7 is a deuterated compound of MK7. MK7 has a CAS number of 2124-57-4. Menaquinone-7 is a vitamin K2 analog, is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins.

Ascorbic acid-13C6 is the 13C labeled compound of Ascorbic acid. Ascorbic acid has a CAS number of 50-81-7. Vitamin C is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen.

L-Ascorbic Acid-13C6 is the 13C labeled compound of L-Ascorbic Acid. L-Ascorbic Acid has a CAS number of 50-81-7. Vitamin C is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen.

VD2-D3 is a deuterated form of vitamin D.

1alpha, 25-Dihydroxy VD2-D6 is a deuterated form of vitamin D.

Calcipotriol-d4 is a deuterated compound of Calcipotriol. Calcipotriol has a CAS number of 112965-21-6. Calcipotriol is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor.

Biotin-d2 is a deuterated compound of Biotin. Biotin has a CAS number of 58-85-5. Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.

Thiamine Hydrochloride-13C4 is the 13C labeled compound of Thiamine Hydrochloride. Thiamine Hydrochloride has a CAS number of 67-03-8. Thiamine Hydrochloride is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, thiamine hydrochloride is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

Menaquinone-9-d7 is a deuterated compound of Menaquinone-9. Menaquinone-9 has a CAS number of 523-39-7. Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats

dimethyl 2-(methyl-d3)malonate is a deuterated compound of dimethyl 2-(methyl)malonate. dimethyl 2-(methyl)malonate has a CAS number of 516-05-2. Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A. It is an indicator of Vitamin B-12 deficiency in cancer.

Doxercalciferol-d3 is the deuterated form of Doxercalciferol and ACTS as vitamin D receptor activator (VDRA), which is a vitamin D2 analogue.

2-Methylpropanedioic acid-d3 is a deuterated compound of 2-Methylpropanedioic acid. 2-Methylpropanedioic acid has a CAS number of 516-05-2. Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A. It is an indicator of Vitamin B-12 deficiency in cancer.

Maxacalcitol-D6 is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol).

25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2.

Calcifediol-D6 is the deuterated form of Calcifediol, which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalciferol 25-hydroxylase.